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A COHORT STUDY ON THE CANCER INCIDENCE IN AN AREA WHERE HTLV I, HCV AND HBV ARE ENDEMIC

Research Project

Project/Area Number 14570342
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionNagasaki University

Principal Investigator

ARISAWA Kokichi  Nagasaki University, Graduate School of Biomedical Sciences (Department of Molecular Microbiology and Immunology), Associate Professor, 大学院・医歯薬学総合研究科, 助教授 (30203384)

Co-Investigator(Kenkyū-buntansha) YOKOO Michiyo  Nagasaki University, Graduate School of Biomedical Sciences (Department of Molecular Microbiology and Immunology), Research Associate, 大学院・医歯薬学総合研究科, 助手 (00336158)
KATAMINE Shigeru  Nagasaki University, Graduate School of Biomedical Sciences (Department of Molecular Microbiology and Immunology), Professor, 大学院・医歯薬学総合研究科, 教授 (40161062)
SOBUE Tomotaka  National Cancer Center Research Institute, Cancer Information and Epidemiology Division, Chairman, がん情報研究部, 部長 (50270674)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2003: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2002: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsHTLV-1 / HCV / HBV / Cohort study / Cancer Incidence / Liver cancer / 交互作用 / 胃がん
Research Abstract

(1) Interleukin-10 promoter polymorphism and liver fibrosis progression in patients with chronic hepatitis C in Japan.
We examined the inheritance of three biallelic polymorphisms in the IL-10 gene promoter, at positions -1082, -819, and -592 from the transcription start site, which produce three different haplotypes, in 52 healthy subjects and 114 patients with post-transfusion hepatitis C. Patients were classified into slow or no-progression group (34 patients), intermediate progression group (33 patients) and rapid progression group (47 patients), based on the degree of fibrosis of liver biopsy specimens : The slow progression group had the putative high IL-10 producing GCC haplotype more often than, the intermediate and rapid progression groups (p<0.01). Individuals with the GCC haplotype were more likely to have less hepatic fibrosis than individuals with the ATA or ACC haplotypes (odds ratio 0.1, 95% confidence interval 0.01-0.9). These results indicate that, in chronic hepatitis … More C, the putative high IL-10 production haplotype GCC is associated with inhibition of the progression of liver fibrosis.
(2)The des-gamma-carboxy prothrombin index is a new prognostic indicator for hepatocellular carcinoma.
Background : Des-gamma-carboxy prothrombin (DCP) has been reported to be an important prognostic factor in patients with hepatocellular carcinoma (HCC). Recently, a monoclonal antibody, 19B7, which recognizes the Gla domain of. DCP, has been identified. The 19B7 antibody recognizes an epitope different from that recognized by MU-3, which is another antibody against DCP. In this study, the authors investigated the measurement of DCP using the antibodies MU-3 and 19B7, respectively, as a prognostic factor for patients with HCC who had solitary, small tumors and or Child Stage AHCC.
Methods : One hundred four patients with HCC who had solitary, small tumors or Child Stage A tumors were enrolled in the study between 1991 and 2001. All patients were treated and were followed for a mean of 3.2 years. The authors analyzed the correlation between the DCP Index (DCP measured by MU-3 and DCP measured by 19B7) and patient prognosis. The patients were classified into 3 groups based on their DCP Index :1) DCP negative (DCP<40 milli arbitrary unit (mAU)/mL)), 2)low DCP Index (DCP> or = 40mAU/mL ; MU-3:19B7 ratio, <3.0, and-3) high DCP Index (DCP> or 40mAU/mL ; MU-3:19B7 ratio, > or= 3.0).
Results : The survival rate for patients in the high DCP Index group was lower compared with the survival rate for patients in the DCP-negative group and was significantly lower compared with the survival rate for patients in the low DCP Index group. In a univariate Cox proportional hazards model, the positive factors were high DCP Index and low DCP Index. Among the positive predictive factors that were analyzed using a multivariate Cox proportional hazards model were age (hazard ratio, 3.27; P=0.006), low DCP Index (hazard ratio, 2.87; P=0.012), and high DCP Index (hazard ratio, 12.3, P<0.0001).
Conclusions : The prognosis of patients who had a high DCP Index score was poorer compared with patients who had a low DCP Index score and patients who were classified as DCP negative. The authors concluded that the DP Index is a prognostic indicator for patients with HCC. Copyright 2003 American Cancer Society.
(3)Human T lymphotropic virus type-I infection, survival and cancer risk in southwestern Japan : A prospective cohort study.
Objectives : This study prospectively evaluated the associations of HTLV I infection with survival and cancer incidence.
Methods : The study base comprised 4,297 adults (aged 40-69 years in 1993) who had either visited the outpatient clinic or who had received annual health check-ups at the A Hospital, Nagasaki, Japan, between 1985 and 1992 (HTLV I seropositivity=24.7%). During the follow-up period (1993-1999 or 2000), 290 deaths and 261 cases of malignant neoplasms occurred, including 10 deaths and six incident cases of adult T -cell leukemia/lymphoma (ATL).
Results : After adjustment for gender, age and other covariates, HTLV-I seropositivity was associatedd with an increased mortality from all-causes excluding ATL (rate ratio [RR] 1.3, 95% confidence interval [CI] 1.0-1.7), all non-neoplastic diseases (RR 1.6, 95% CI 1.1-2.3) and heart diseases. HTLV I infection was not found to be associated with an increased risk of developing total cancers other than ATL (RR 0.97, 95% CI 0.73-1.3), colorectal cancers, liver cancer or lung cancer, but was associated with a reduced risk of gastric cancer, (RR=0.42, 95% CI 0.18-0.99).
Conclusions : HTLV I infection is associated with increased mortality from all-causes excluding ATL and all non-neoplastic diseases. HTLV I carriers may not be at increased general cancer risk, but at reduced risk of gastric cancer. Less

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] Arisawa K: "Human T-lymphotropic virus type-I infection, survival and cancer risk in southwestern Japan : A prospective cohort study"Cancer Causes and Control. 14(9). 889-896 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohgi S: "Randomized controlled trial of swaddling versus massage in the management of excessive crying in infants with cerebral injuries"Archives of Disease in Childhood. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nagaoka S: "The des-gamma-carboxy prothrombin index is a new prognostic indicator for hepatocellular carcinoma"Cancer. 98(12). 2671-2677 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohgi S: "Neonatal behavioral characteristics and later behavioral problems"Clinical Pediatrics. 42(8). 679-686 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hamada H: "Interleukin-10 promoter polymorphism and liver fibrosis progression in patients with chronic hepatitis C in Japan"Journal of Hepatology. 39(3). 457-458 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Arisawa K: "Fish intake, plasma omeea-3 polyunsaturated fatty acids, and PCDDs/PCDFs and co-PCBs in the blood of the Japanese population"International Archives of Occupational and Environmental Health. 76(3). 205-215 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hamada H, Yatsuhashi H, Hamasaki K, Yano K, Arisawa K, Daikoku M, Koga M, Miyazoe S, Nakao K, Eguchi K, Yano M.: "Interleukin-10 promoter polymorphism and liver fibrosis progression in patients with chronic hepatitis C in Japan."Journal of Hepatology. 39(3). 457-458 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nagaoka S, Yatsuhashi H, Hamada H, Yano K, Matsumoto T, Daikoku M, Arisawa K, Ishibashi H, Koga M, Sata M, Yano M.: "The des-gamma-carboxy prothrombin index is a new prognostic indicator for hepatocellular carcinoma."Cancer. 98(12). 2671-2677 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Arisawa K, Sobue T, Yoshimi I, Soda M, Shirahama S, Doi H, Katamine S, SaitoH, Urata M.: "Human T-lymphotropic virus type-I infection, survival and cancer risk in southwestern Japan : A prospective cohort study."Cancer Causes and Control. 14(9). 889-896 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hamada H, Yatsuhashi H, Yano K, Daikoku M, Arisawa K, Inoue O, Koga M, Nakata K, Eguchi K, Yano M: "Impact of aging on the development of HCC in post-transfusion chronic hepatitis"C.Cancer. 95(2). 331-339 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Arisawa K, Katamine S, Kamihira S, Kurokawa K, Sawada T, Soda M, Doi H, Saito H, Shirahama S.: "A nested case-control study of risk factors forr adult T-cell leukemia/lymphoma among human T-cell lymphotropic virus type-I carriers in Japan."Cancer Causes and Control. 13(7). 657-663 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Arisawa K, Soda M, Shirahama S, Saito H, Takamura N, Yamaguchi M, Odagiri K, Nakagoe T, Suyama A, Doi H: "Geographic distribution of the incidence of adult T-cell leukemia/lymphoma and other malignancies in Nagasaki Prefecture, Japan."Japanese Journal of clinical Oncology. 32(8). 301-306 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Arisawa K, Matsumura T, Tohyama C, Saito H, Satoh H, Nagai M, Morita M, Suzuki T: "Fish intake, plasma omega-3 polyunsaturated fatty acids, and polychlorinated dibenzo p-dioxins (PCDDs)/polychlorinated dibenzo-furans (PCDFs) and coplanar polychlorinated biphenyls (co-PCBs) in the blood of the Japanese population."International Archives of Occupational and Environmental Health. 76(3). 205-215 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Arisawa K: "Human T-lymphotropic virus type-I infection, survival and cancer risk in southwestern Japan : A prospective cohort study"Cancer Causes and Control. 14(9). 889-896 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ohgi S: "Randomized controlled trial of swaddling versus massage in the management of excessive crying in infants with cerebral injuries"Archives of Disease in Childhood. (in press).

    • Related Report
      2003 Annual Research Report
  • [Publications] Nagaoka S: "The des-gamma-carboxy prothrombin index is a new prognostic indicator for hepatocellular carcinoma"Cancer. 98(12). 2671-2677 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ohgi S: "Neonatal behavioral characteristics and later behavioral problems"Clinical Pediatrics. 42(8). 679-686 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hamada H: "Interleukin-10 promoter polymorphism and liver fibrosis progression in patients with chronic hepatitis C in Japan"Journal of Hepatology. 39(3). 457-458 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Arisawa K: "Fish intake, plasma omega-3 polyunsaturated fatty acids, and PCDDs/PCDFs and co-PCBs in the blood of the Japanese population"International Archives of Occupational and Environmental Health. 76(3). 205-215 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Arisawa K: "Fish intake, plasma omega-3 polyunsaturated fatty acids, and polychlorinated dibenzo-p-dioxins/polychlorinated dibenzo-furans and co-planar polychlorinated biphenyls in the blood of the Japanese population"Int. Arch. Occup. Environ. Health. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Arisawa K: "A nested case-control study of risk factors for adult T-cell leukemia/lymphoma among HTLV-I carriers in Japan"Cancer Causes & Control. 13(9). 657-663 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Arisawa K: "Geographic Distribution of the Incidence of Adult T-cell Leukemia/Lymphoma and Other Malignancies in Nagasaki Prefecture, Japan"Jpn J. Clin Oncol. 32(8). 301-306 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hamada H: "Impact of aging on the development of HCC in post-transfusion chronic hepatitis C"Cancer. 95(2). 331-339 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takazawa K: "Lower-extremety muscle forces measured by a hand-held dynamometer and the risk of talls among day-care users in Japan"Disabl. Rehabil. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Ohgi S: "Neonatal behavioral assessment scale as a predictor of later developmental disabilities of low birth-weight and/or premature infants"Brain Dov. (in press).

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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