| Co-Investigator(Kenkyū-buntansha) |
YAGYU Kiyoko Aichi Medical University, School of Medicine, Research Associate, 医学部, 助手 (50268017)
YINGSONG Lin Aichi Medical University, School of Medicine, Lecturer, 医学部, 講師 (50340302)
OBATA Yuki Aichi Medical University, School of Medicine, Research Associate, 医学部, 助手 (70340304)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2002: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Research Abstract |
Using plasma of 55 stomach cancer patients under 40 years of age and their age and gender matched 55 screenees, pepsinogen (PG), H. pylori antibody, inteleukine-8 (IL-8), Cu, Zn-superoxide dismutase (Cu, Zn-SOD), inteleukine-6 (IL-6), epidermal growth factor (EGF), its receptor (EGF-R), transforming growth factor β-1 (TGF β-1), soluble Fas (sFas) and midkine were measured.
High PG1 and PG2 concentrations and low PG1/PG2 ratio were positive related with risk for stomach cancer. The optimal sensitivity and specificity were 83.3% and 81.5%. Cu, Zn-SOD, EGF, EGF-R, TGF β-1, and sFas showed negative association with the risk, but the significant association of TGF β-1, and sFas disappeared when adjusted for H. pylori status. The negative association of EGF and EGF-R can be explained by feedback down-regulation or increased consume of the factors. The disappearance of significance regarding TGF β-1, and sFas by adjustment for H. pylori status seems to indicate that relationship between these factors and risk for stomach cancer is related with H pylori infection.
IL-6 showed positive association with risk for stomach cancer, but significance disappeared with adjustment for H pylon status. From the results it may be hypothesized that H pylori infection elevated and the elevated IL-6 increased risk for stomach cancer. However, further investigation is necessary to confirm the hypothesis.
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