| Co-Investigator(Kenkyū-buntansha) |
SODA Midori Radiation Effects Research Foundation, Epidemiology Assistant Department, Chief (Researcher), 疫学部, 副部長(研究員) (00359457)
AKAHOSHI Masazumi Radiation Effects Research Foundation, Epidemiology Assistant Department, Chief (Researcher), 臨床研究部, 部長(研究員) (30359450)
KONDO Hisayoshi Nagasaki University, School of Medicine, Assistant, 医学部, 助手 (00170431)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2003: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2002: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Research Abstract |
The relationship between lipid or glucose metabolism and cancer has not yet been elucidated. We conducted 75g oral glucose tolerance tests (75g OGTT) and lipid measurements between 1983 and 1985 in 516 Nagasaki atomic bomb survivors. Excluding those who already had cancer at the baseline examinations and those who developed cancers or died of any cause within five years after the baseline examinations, we determined incident cancer cases until 2000 in the remaining 451 subjects (214 males and 237 females) and evaluated whether glucose or lipid metabolism predicts cancer development by means of Cox proportional hazard model.
The age- and sex-adjusted relative risk (RR) for incident cancer was 0.903 (95% confidence interval (95%CI), 0.842-0.968), 1.740 (95% CI, 1.238-2.446), 1.653 (95% CI, 0.922-2.965) and 1.024 (95% CI, 0.996-1.053) for total cholesterol (10mg/dl), radiation dose (1Sv, smoking and 1-hour blood glucose (1h BG; 10mg/dl) in 75g OGTT, respectively. Multiple regression analysis of age, sex, smoking, body mass index, lh BG, triglycerides, total cholesterol, HDL cholesterol, and radiation dose also showed that total cholesterol was negatively (RR, 0.876; 95% CI, 0.791-0.957) and radiation dose positively (RR, 1.809; 95% CI, 1.252-2.613) related to incident cancer.
Cholesterol could be negatively and radiation dose positively associated with cancer development independently.
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