| Project/Area Number |
14570405
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
内科学一般
|
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KAWASAKI Hiroshi The University of Tokyo, Institute of Medical Science, Research Assistant, 医科学研究所, 助手 (80280957)
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|---|
| Project Period (FY) |
2002 – 2003
|
| Project Status |
Completed (Fiscal Year 2003)
|
| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2003: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2002: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | cytokine / chemokine / dendritic cell / signal transduction / antigen presentation / allergy / infalmmation / autoimmunity / 自己免疫疾患 |
|---|
| Research Abstract |
To clarify the mechanism of the initiation of an Ag-specific immune response in epidermis in the human system, we examined the role of the interplay between dendritic cells (DCs) and Langerhans cells (LCs) in vitro. DCs exhibited more potent expressions of the MHC product and costimulatory molecules than LCs. LCs were less effective for the internalization of exogenous Ag, and the activation of allogeneic and autologous Ag-specific T cells than DCs. DCs and LCs expressed different in chemokine receptor repertoire and responsiveness. LCs can transfer unprocessed Ag to DCs via cell to cell contact, and these trans-Ag-loaded DCs induced an Ag-specific T cell response
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