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IL-12-mediated regulation of human chemokine receptor function

Research Project

Project/Area Number 14570405
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 内科学一般
Research InstitutionThe University of Tokyo

Principal Investigator

KAWASAKI Hiroshi  The University of Tokyo, Institute of Medical Science, Research Assistant, 医科学研究所, 助手 (80280957)

Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2003: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2002: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordscytokine / chemokine / dendritic cell / signal transduction / antigen presentation / allergy / infalmmation / autoimmunity / 自己免疫疾患
Research Abstract

To clarify the mechanism of the initiation of an Ag-specific immune response in epidermis in the human system, we examined the role of the interplay between dendritic cells (DCs) and Langerhans cells (LCs) in vitro. DCs exhibited more potent expressions of the MHC product and costimulatory molecules than LCs. LCs were less effective for the internalization of exogenous Ag, and the activation of allogeneic and autologous Ag-specific T cells than DCs. DCs and LCs expressed different in chemokine receptor repertoire and responsiveness. LCs can transfer unprocessed Ag to DCs via cell to cell contact, and these trans-Ag-loaded DCs induced an Ag-specific T cell response

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (23 results)

All 2004 2003 2002 Other

All Journal Article (12 results) Book (1 results) Publications (10 results)

  • [Journal Article] The tetraspanin CD9 is preferentially expressed on the human CD4+CD45RA+ naive T cell population and is involved in T cell activcation2004

    • Author(s)
      Kobayashi, H
    • Journal Title

      Clinical and Experimental Immunology 137

      Pages: 101-108

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] The tetraspanin CD9 is preferentially expressed on the human CD4(+)CD45RA+ naive T cell population and is involved in T cell activation.2004

    • Author(s)
      Kobayashi H
    • Journal Title

      Clinical and Experimental Immunolgy 137(1)

      Pages: 101-108

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Ebastine inhibits T cell migration, production of Th2 type cytokine and proinflammatory cytokines2003

    • Author(s)
      Nori, M
    • Journal Title

      Clinical and Experimental Allergy 33

      Pages: 1544-1555

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Role of Crk-associated substrate lymphocyte type in the pathophysiology of Rheumatoid arthritis in tax transgenic mice and humans2003

    • Author(s)
      Miyake-Nishijima, R
    • Journal Title

      Arthritis and Rheumatism 48

      Pages: 1890-1900

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Ebastine inhibits T cell migration, production of Th2-type cytokines and proinflammatory cytokines.2003

    • Author(s)
      Nori M
    • Journal Title

      Clincal and Experimental Allergy. 33(11)

      Pages: 1544-1554

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Role of Crk-associated substrate lymphocyte type in the pathophysiology of rheumatoid arthritis in tax transgenic mice and in humans.2003

    • Author(s)
      Miyake-Nishijima R
    • Journal Title

      Arthritis and Rheumatism 48(7)

      Pages: 1890-1900

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] G1/S cell cucle arrest provoked in human T cells by antibody to CD26.2002

    • Author(s)
      Ohnuma, K
    • Journal Title

      Immunology 107

      Pages: 325-333

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Reduction of serum soluble 26/dipeptidyl peptidase IV enzyme activity and its correlation with disease activity in systemic lupus erythematosus2002

    • Author(s)
      Kobayashi, H
    • Journal Title

      Journal of Rheumatology 29

      Pages: 1858-1866

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] G1/S cell cycle arrest provoked in human T cells by antibody to CD26.2002

    • Author(s)
      Ohnuma K
    • Journal Title

      Immunology 107(3)

      Pages: 325-333

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Reduction of serum soluble CD26/dipeptidyl peptidase IV enzyme activity and its correlation with disease activity in systemic lupus erythematosus.2002

    • Author(s)
      Kobayashi H
    • Journal Title

      Journal of Rheumatol. 29(9)

      Pages: 1858-1866

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] An abortive ligand-induced activation of CCR1-mediated downstream signaling event and a deficiency of CCR5 expression are associated with the hyporesponsiveness of human naive CD4+ T cells to CCL3 and CCL5.2002

    • Author(s)
      Sato K
    • Journal Title

      Journal of Immunolgy. 168(12)

      Pages: 6263-6272

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Distinctive signaling pathways through CD82 and betal integrins in human T cells.2002

    • Author(s)
      Iwata S
    • Journal Title

      European J Immunol. 32(5)

      Pages: 1328-1337

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Book] 腎炎2004

    • Author(s)
      谷口茂夫 (分担執筆)
    • Total Pages
      140
    • Publisher
      文光堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nori, M et al.: "Ebastine inhibits T cell migration, production of Th2-type cytokines, and proinflammatory cytokines"Clinical and Experimental Allergy. 33・11. 1544-1554 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Miyake-Nishijima, R et al.: "Role of Crk-associated substrate lymphocyte rype in pathophysiology of rheumatid Arthitis in Tax transgenic mice and human"Athritis and Rhematism. 48・7. 1890-1900 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ohnuma, K et al.: "G1・S cell cycle arrest provoked in human T cells by antibody to CD26"Immunology. 107・3. 325-333 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kobayashi, H et al.: "Reduction of serum soluble CD26 and its correlation of disease activity in Systemic Lupus Erythematosus"Journal of Rheumatology. 29・9. 1858-1866 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Iwata, S et al.: "Distinctive signaling pathway through CD82 and betal Integrins in human T cells"European Journal of Immunology. 32・5. 1328-1337 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sato, K et al.: "An abortive ligand induced activation of CCR1-mediateddownstream signaling event and a deficiency of CCR5 expression"Journal of Immunology. 167・12. 6263-6272 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Olinuma K: "G1/S Cell Cycle Arrest Provoked in Human T cels by Antibody to CD26"Immunology. 107(3). 325-333 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kobayashi H: "Reduction of Serum Soluble CD26/DPP IV Enzyme Activity and its Correlation with Disease Activity in SLE"Journal of Rheumatology. 29(9). 1858-1866 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sato K: "An Abortive Ligand-Induced Activation of CCR-1 Mediated Downstream Signaling Event and A Deficiency of CCR-5 Exnression"Journal of Immunology. 168(12). 6263-6272 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Iwata S: "Distinctive Signaling Pathways Through CD82 and Beta 1 Intergrins In Human T Cells"European Journal of Immunology. 32(5). 1328-1337 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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