| Project/Area Number |
14570427
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
内科学一般
|
|---|
| Research Institution | Kitasato University |
|---|
Principal Investigator |
ENDO Hirahito Kitasato University, School of Medicine, Associate professor, 医学部, 助教授 (20213598)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TANAKA Sumiaki Kitasato University, School of Medicine, Assistant professor, 医学部, 講師 (80265595)
YOSHIDA Hide Kitasato university, School of Medicine, Research Associate, 医学部, 助手 (60327377)
内山 真主美 北里大学, 医学部, 助手 (40296447)
|
|---|
| Project Period (FY) |
2002 – 2005
|
| Project Status |
Completed (Fiscal Year 2005)
|
| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2005: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2004: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2003: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2002: ¥800,000 (Direct Cost: ¥800,000)
|
|---|
| Keywords | interstitial pneumonitis / bleomycin / 15 deoxy-prostaglandin J2 / Lipoxin / Thromboxane / Scleroderma / Leukotriene / ロイトリエン / プロスタグランジン / プロスタグランジン受容体 / PPARγ / プロスタクランジンE_2 / プロスタブランジンE受容体 |
|---|
| Research Abstract |
1.15 deoxy-prostaglandin J2 (15d-PGJ2) suppress mouse interstitial pneumonitis induced bleomycin. 15d-PGJ2 is a legand of nuclear receptor, peroxysome-proliferator activated receptor gamma. PPAR gamma highly expressed in lung lesion of bleomycin-induced interstitial pneumonitis
15d-PGJ2 is a stable metabolite of PGD2. PGD syntase retrovirally transfected fibroblasts also inhibited interstitial pneumonitis.
2.15d-PGJ2 inhibited skin sclerosis and lung fibrosis in bleomycin-induced mouse scleroderma model. In this disease model mast cells highly infiltrated in skin and lung and plasma histamine levels increased in this model. 15-dPGJ2 inhibited mast cell activation, histamine release.
3.Lipoxin A4 receptor (ALX) increased bleomycin-induced interstitial pneumonitis. Lipoxin A4 inhibited TGF beta induced lung fibroblast proliferation and collagen synthesis. And TXA2 receptor also induced in induced. ALX induced by TX syntase inhibitor.
|
