Relationship between CC chemokine expression in the airways of severe asthmatics and steroid resistance
| Project/Area Number |
14570428
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
内科学一般
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| Research Institution | KEIO UNIVERSITY |
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Principal Investigator |
NAKAMURA Hidetoshi Keio University, School of Medicine, Assistant, 医学部, 助手 (00217879)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAJIMA Takahiro Keio University, School of Medicine, Assistant, 医学部, 助手 (70306702)
ASANO Koichiro Keio University, School of Medicine, Assistant Professor, 医学部, 講師 (60192944)
YAMAGUCHI Kazuhiro Keio University, School of Medicine, Associate Professor, 医学部, 助教授 (30129712)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2002: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | asthma / severity / eotaxin / steroid / bradykinin / TGF-β1 / oncostatin-M / TGF-β / CCケモカイン / eotaxin / MCP-4 / IL-5 |
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| Research Abstract |
Among biomarkers of asthma severity studied, plasma eotaxin level was not significantly affected by corticosteroid treatment, and was associated with the severity of stable asthmatics even in the presence of steroid therapy. There was a significant correlation between the pretreatment levels of plasma eotaxin and the extent of functional improvement after steroid treatment in unstable asthmatics. These results suggest that plasma eotaxin level is a marker of disease activity and/or treatment response to steroids in unstable asthma.
Bradykinin concentrations in exhaled breath condensate in asthmatics were detectable but were not different from those in normal subjects. Eotaxin production in human fetal fibroblast (HFL-1) was slightly increased by Bradykinin. TNF-α strongly induced eotaxin production in this cell line which was moderately inhibited by the addition of oncostatin-M or TGF-β1. The inhibitory effects of steroid on eotaxin production were further enhanced by coincubation with TGF-β1.
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Report
(3 results)
Research Products
(10 results)
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[Publications] Asano K, Shiomi T, Hasegawa N, Nakamura H, Kudo H, Matsuzaki T, Hakuno H, Fukunaga K, Shiomi T, Suzuki Y, Kanazawa M, Yamaguchi: "Leukotriene C_4 synthase gene A(-444)C polymorphism and clinical response to a cys-LT_1 antagonist, Pranlukast, in Japanese patients with moderate asthma."Pharmacogenetics. 12. 565-570 (2002)
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