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API2-MALT1 translocation and tumorgenesis in gastric MALT lymphoma

Research Project

Project/Area Number 14570437
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

SUGIYAMA Toshiro  Hokkaido University, Graduate School of Medicine, Prof., 大学院・医学研究科, 助教授 (00196768)

Co-Investigator(Kenkyū-buntansha) ASAKA Masahiro  Hokkaido University, Graduate School of Medicine, Prof., 大学院・医学研究科, 教授 (10113507)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2003: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2002: ¥1,900,000 (Direct Cost: ¥1,900,000)
KeywordsH.pylon / Gastric MALT lymphoma / API2-MALT1 chimeric transcript / NF-kB activation / NF-κB / アポトーシス
Research Abstract

Total gastrectomy was an established conventional treatment against gastric MALT lymphoma. As the 60-80% of gastric MALT lymphoma regress by an eradication treatment of H.pylon and the remaining 20-40% does not, the predictive factor to eradication treatment should be clinically identified. The translocation between API2 gene in Ch11 and MALT1 gene in Ch18 was observed in a part of gastric MALT lymphoma and the high sensitive detection method of the chimeric transcript was established By using this system, the presence of API2-MALT1 chimeric transcript was an important predictive factor to resist for eradication treatment. These results suggest us that the presence of API2-MALT1 chimeric transcript might have a causal linkage to occurrence of eradication-resistant gastric MALT lymphoma. The transfection of API2-MALT1 chimeric cDNA into COS7 cells have induced an accumulation of the chimeric protein within the cytoplasm and demonstrated the delayed degradation of the protein. The accumulation of the chimeric protein within the cytoplasm resulted in an activation of NF-kB in the nucleus. Therefore, the presence of API2-MALT1 chimenc transcript might have a causal linkage to tumorgenesis via NF-kB activation in eradication-resistant gastric MALT lymphoma.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Ishizuka J Sugiyama T, et al.: "Molecular cloning of p53 of Mongolian gerbil and establishment of yeast functional assay system"Helicobacter. 8. 81-89 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nagasako T, Sugiyama T, et al.: "Up-regulated Smad5 mediates apoptosis of gastric epithelial cells induced by H.pylori infection"J Biol Chem. 278. 4821-4825 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Marchildon PA, Sugiyama T: "Evaluation of the effects of strain-specific antigen variation on the accuracy of sero-diagnosis of Helicobacter pylori Infection"J Clin Microbiol. 41. 1480-1485 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sugiyama T, Asaka M: "Molecular basis for development of gastric cancer -in vivo and in vitro study-"Keiio J Med. 51. 57-62 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sugiyama T, et al.: "H.Pylori eradication for intractable gastric ulcer"Aliment Pharmacol Ther. 18. 543-544 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Higashi H, Sugiyama T, et al.: "SHP-2 tyrosine phosphatase as an intracellular target of H.pylori CagA protein"Science. 295. 683-686 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishizuka J, Sugiyama T, Hirayama F, Tada M, Moriuchi T, Asaka M: "Molecular cloning of p53 of Mongolian gerbil and establishment of yeast functional assay system"Helicobacter. 8. 81-89 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nagasako T, Sugiyama T, Mizushima T, Miura Y, Asaka M: "Upregulated Smad 5 mediates apoptosis of gastric epithelial cells induced by H.pylori infection"J Biol Chem. 278. 4821-4825 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Marchildon PA, Sugiyama T, Fukuda Y.Asaka M, Shimoyama T, Graham, DY: "Evaluation of the effects of strain-specific antigen variation on the accuracy of serologic diagnosis of Helicobacter pylori lnfection"J Clin Microbiol. 41. 1480-1485 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sugiyama T, Asaka M.: "Molecular basis for development of gastric cancer -in vivo and in vitro study-"Keiio J Med. 51. 57-62 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sugiyama T, Asaka M: "H.pylori eradication for intractable gastric ulcer"Aliment Pharmacol Ther. 18. 543-544 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Higashi H, Tsutsumi R, Muto S, Sugiyama T, Azuma T, Asaka M, Hatakeyama M.: "SHP-2 tyrosine phosphatase as an intracellular target of H.pylori CagA protein."Science. 295. 683-686 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishizuka J, Sugiyama T, et al.: "Molecular cloning of p53 of Mongolian gerbil and establishment of yeast functional assay system"Helicobacter. 8. 81-89 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nagasako T, Sugiyama T, et al.: "Up-regulated Smad5 mediates apoptosis of gastric epithelial cells induced by H.pylori infection"J Biol Chem. 278. 4821-4825 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Marchildon PA, Sugiyama T: "Evaluation of the effects of strain-specific antigen variation on the accuracy of sero-diagnosis of Helicobacter pylori Infection"J Clin Microbiol. 41. 1480-1485 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sugiyama T, Asaka M: "Molecular basis for development of gastric cancer-in vivo and in vitro study-"Keiio J Med. 51. 57-62 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sugiyama T, et al.: "H.pylori eradication for intractable gastric ulcer"Aliment Pharmacol Ther. 18. 543-544 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kato C, Sugiyama T, et al.: "Appropriate cut-off value of ^<13>C-urea breath test after eradication of H.pylori infection in Japan"J Gastroenterol Hepatol. 18. 1379-1383 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nagasako T, Sugiyama T et al.: "Up-regulated Smad5 mediates apoptosis of gastric epithelial cells induced by H.pylori infection"J Biol Chem. 278. 4821-4825 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Mizushima T, Sugiyama T et al.: "Decreased adherence of cagG deleted Helicobacter pylori to gastric epithelial cells in Japanese clinical isolates"Helicobacter. 7. 22-29 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Higashi H, Sugiyama T, et al.: "SHP-2 tyrosine phosphatase as an intracellular target of H.pylori CagA protein"Science. 295. 683-686 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sugiyama T et al.: "Development of H.pylori-infected animal model and gastric cancer : recent progress and issues"J Gastroenterology. 37. 6-9 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sugiyama T et al.: "Sensitivity biopsy site in evaluating regression of gastric atrophy after Helicobacter pylori eradication treatment"Aliment Pharmacol Ther. 16. 187-190 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kaminishi M, Sugiyama T et al.: "Endoscopic classification of chronic gastritis based on a pilot study by the research society for gastritis"Digestive Endoscopy. 14. 138-151 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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