| Project/Area Number |
14570442
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Akita University |
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Principal Investigator |
OTAKA Michiro Akita University, School of Medicine, Assistant Professor, 医学部, 講師 (30250872)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Sumio Akita University, School of Medicine, Professor, 医学部, 教授 (20138225)
ITOH Hideaki Akita University, Faculty of Engineering and Resource Science, Professor, 工学資源学部, 教授 (80168369)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2003: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2002: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | molecular chaperon / gastric mucosal protection / gastric mucosal restoration / stress / gastric ulcer / gastric mucosal lesion / heat shock protein / 損傷修復 / 胃粘膜傷害 / 粘膜防御 / 消化性潰瘍 / 粘膜修復 / 亜鉛 / 胃粘膜障害 |
|---|
| Research Abstract |
Many recent studies have indicated the importance of heat shock (proteins (HSPs) for survival of cells under stress conditions. Some HSPs are known to be involved in cytoprotection against environmental stresses mediated by their function as a "molecular chaperon". We have reported that a 72-kDa heat shock protein (HSP72, stress-inducible HSP7O) plays essential role in the gastric and colonic mucosa in vivo.
In the present study demonstrated that
1)When gastric mucosal HSP72 is induced by zinc derivatives, protective ability and wound restoration are enhanced in vitro and in vivo.
2)Over-expression of HSP72 by gene-transfection clearly enhanced cytoprotective ability against ethanol-induced cell damage and wound restoration in cultured gastric mucosal cells.
Our results suggested that expression of HSP72 could play important roles not only in cytoprotection but also in mucosal wound restoration mediated by the function as a molecular chaperon of HSP72.
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