| Project/Area Number |
14570525
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
FUKUDA Yoshihiro Hyogo College of Medicine, Faculty of medicine, Associate Professor, 医学部, 助教授 (60148640)
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| Co-Investigator(Kenkyū-buntansha) |
TAMURA Kazuo Hyogo College of Medicine, Faculty of medicine, Associate Professor, 医学部, 助教授 (20278823)
KOSAKA Tadashi Hyogo College of Medicine, Faculty of medicine, Research Associate, 医学部, 助手 (90330464)
TANIDA Noritoshi Hyogo College of Medicine, Faculty of medicine, Associate Professor, 医学部, 助教授 (30140437)
TAMURA Kazutami Hyogo College of Medicine, Faculty of medicine, Assistant Professor, 医学部, 講師 (70104247)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2003: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2002: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | Crohn's disease / mRNA / phage display / 炎症性腸疾患 / DNAマイクロアレイ / 抗CDP抗体 / ABCB1遺伝子 / C3435T多型 |
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| Research Abstract |
To examine Crohn's disease specific gene expression, blood samples were collected from Crohn's disease patients and healthy volunteers, and the lymphocytes and monocytes were separated. After stimulation with Crohn's disease specific peptide, mRNA expression was detected using the cDNA allay. The pattern of which the gene expression differed was shown, when it analyzed the manifest gene in cluster, and when it compared it in Crohn's disease patients and healthy volunteers. The gene cluster which has peculiarly appeared of Crohn's disease there were disease type, condition and relevance, and they seemed to be useful for prediction and prognostication of the reactivity for the treatment, elucidation of etiology and exacerbation factor besides.
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