| Project/Area Number |
14570583
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | NIIGATA UNIVERSITY |
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Principal Investigator |
TANAKA Keiko NIIGATA UNIVERSITY, Brain Research Institute, Associate Professor, 脳研究所, 助教授 (30217020)
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| Co-Investigator(Kenkyū-buntansha) |
TSUJI Shoji the University of Tokyo, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (70150612)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2002: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | paraneopolastlc neurological syndrome / anti-neuronal antibody / recombinant antigen protein / 融合蛋白 |
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| Research Abstract |
For the specific and quick diagnosis of paraneoplastic neurological syndromes, we produced several recombinant antigen proteins (Yo/Hu/Ri/CRMP-5,/Ma-2) and used as antigens for western blot or ELISA. We analysed the frequency of these antibody positivity among 1500 samples which sent us for the diagnosis of paraneoplastic neurological syndromes. We found anti-Yo antibody in 1.5% of these sera and anti-Hu antibody in 2.3%.
For those with specific antibody-positive patients, we analysed the HLA type under the informed consent, and found the similar amimo acid motifs in their class I molecules, which would be used as the targets for cytotoxic T cell assay.
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