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Abnormal function of the motor circuit in chorea and dystonia : a comparison with Parkinson's disease.

Research Project

Project/Area Number 14570586
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionShinshu University

Principal Investigator

HASHIMOTO Takao  Shinshu University, School of Medicine, Associate Professor, 医学部, 助教授 (20201709)

Co-Investigator(Kenkyū-buntansha) TADA Tsuyoshi  Shinshu University, Shinshu University Hospital, Lecturer, 医学部附属病院, 講師 (00236530)
Project Period (FY) 2002 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2004: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2003: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2002: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordschorea / dystonia / Parkinson's disease / stereotactic surgery / pallidotomy / 視床 / 定立脳手術 / 淡蒼球破壊術
Research Abstract

We studied the effects of stereotactic pallidal and thalamic surgeries on chorea and dystonia and abnormality of the neuronal firing pattern of the internal globus pallidus (GPi). The surgery was performed using microelectrode and CT guiding in 11 parkinsonian patients (6 females and 5 males, 49-74 years old), a patient with dentate-pallidoluysian atrophy showing chorea (Case 1, female, 29 years old, bilateral pallidotomy), a patient with off-dystonia (Case 2, male, 54 years old, unilateral pallidotomy), a patient with primary generalized dystonia (Case 3, female, 55 years old, unilateral pallidal DBS), and a patient with generalized dystonia and intracranial calcification (Case 4, female, 27 years old, bilateral thalamic DBS). Patients were evaluated according to the UPDRS or AIMS. Elgiloy, glass-coated microelectrodes with an impedance of 0.4 MΩ at 1000Hz were used for single-cell recording. No sedation was used in surgery, and all medication was withheld overnight and during surgery. Ten-to 30-second samples of spontaneous single-cell activity from GPi were recorded during mapping and stored on DAT tape. Neuronal signals were digitized at 50kHz, action potentials were discriminated according to the peak amplitude and window aperture onscreen, and the firing rates, oscillation indexes and burst ratios of single-cell action potentials were calculated. Chorea in Case 1 and dystonia in Case 2 were disappeared after surgery. Dystonia in Case 3 and Case 4 was improved by 30-50%. Neuronal recording from GPi during dystonia in Case 2 and Case 3 revealed that the mean firing rates were low, highly bursty and less oscillatory, as compared with firing patterns in off-state parkinsonian patients without dystonia. These results suggest that chorea and dystonia results from the decreased activities of the basal ganglia output, but the altered firing pattern is a significant factor underlying pathophysiology of these movement disorders.

Report

(4 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (20 results)

All 2005 2004 2003 2002 Other

All Journal Article (11 results) Book (2 results) Publications (7 results)

  • [Journal Article] Acute stimulation in the external segment of the globus pallidus improves parkinsonian motor signs.2004

    • Author(s)
      Vitek JL, Hashimoto T, et al.
    • Journal Title

      Mov Disord 19

      Pages: 907-915

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Chronic implantation of deep brain stimulation leads in animal models of neurolozical disorders.2004

    • Author(s)
      Elder CM, Hashimoto, et al.
    • Journal Title

      Neurosci Methods 142

      Pages: 11-16

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] パーキンソン病症候の運動学・病態生理学2004

    • Author(s)
      橋本隆男
    • Journal Title

      脳の科学 2004年増刊号

      Pages: 69-74

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] マイクロレコーディング2004

    • Author(s)
      橋本隆男
    • Journal Title

      脳神経外科 32

      Pages: 297-303

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] 大脳基底核の神経回路2004

    • Author(s)
      橋本隆男
    • Journal Title

      内科 93

      Pages: 623-627

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] パーキンソン病の治療.定位脳手術の種類と適応2004

    • Author(s)
      橋本隆男
    • Journal Title

      診断と治療 92

      Pages: 819-824

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Acute stimulation in the external segment of the globus pallidus improves parkinsonian motor signs.2004

    • Author(s)
      Vitek JL, Hashimoto T, Peoples J, DeLong MR, Bakay RAE.
    • Journal Title

      Mov Disord 19

      Pages: 907-915

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Chronic implantation of deep brain stimulation leads in animal models of neurological disorders.2004

    • Author(s)
      Elder CM, Hashimoto, et al.
    • Journal Title

      Neurosci Methods 142

      Pages: 11-16

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effects of unilateral pallidotomy on voluntary movement, and simple and choice reaction times in Parkinson's disease.2003

    • Author(s)
      Hayashi R, Hashimoto T, Tada T, Ikeda S.
    • Journal Title

      Mov Disord 18

      Pages: 515-523

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Stimulation of the subthalamic nucleus changes the firing pattern of pallidal neurons.2003

    • Author(s)
      Hashimoto T, Elder CM, Okun MS, Patrick SK, Vitek JL.
    • Journal Title

      J Neurosci 23

      Pages: 1916-1923

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Abnormal conditioning effect of transcortical magnetic stimulation on soleus H-reflex during voluntary movement in Parkinson's disease.2002

    • Author(s)
      Morita H, Shindo M, Morita S, Hashimoto T, Tada T, Ikeda S.
    • Journal Title

      Clin Neurophysiol 113

      Pages: 1316-1324

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Annual Review神経20052005

    • Author(s)
      橋本隆男
    • Total Pages
      8
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Annual Review神経20052005

    • Author(s)
      橋本隆男
    • Related Report
      2004 Annual Research Report
  • [Publications] Hashimoto T, Elder CM, et al.: "Stimulation of the subthalamic nucleus changes the firing pattern of pallidal neurons"J Neurosci. 23. 1916-1923 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sekijima Y, Hashimoto T, et al.: "Severe generalized dystonia as a presentation of a patient with aprataxin gene mutation"Mov Disord. 18. 1198-1200 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Watarai M, Hashimoto T, et al.: "Pallidotomy for severe generalized chorea of juvenile-onset dentatorubral-pallidolyusian atrophy"Neurology. 61. 1452-1454 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hagiwara N, Hashimoto T, et al.: "Static balance impairment and its change after pallidotomy in Parkinson's patients"Mov Disord. In press. (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 橋本隆男: "血管性舞踏病とヘミバリスムの病態と神経機序"運動障害. 12巻. 49-55 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hayashi R, Hashimoto T, et al.: "Effects of unilateral pallidotomy on voluntary movement, and simple and choice reaction times in Parkinson's disease"Movement Disorders. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] 橋本隆男: "随意運動と不随意運動の違"Clinical Neuroscience. 20巻. 1240-1243 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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