| Project/Area Number |
14570649
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Gifu University |
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Principal Investigator |
KOZAWA Osamu Gifu University, School of Medicine, Professor, 医学部, 教授 (90225417)
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| Co-Investigator(Kenkyū-buntansha) |
AKAMATSU Shigeru Gifu University, School of Medicine, Assistant professor, 医学部附属病院, 講師 (20167828)
MATSUNO Hiroyuki Gifu University, School of Medicine, Associate professor, 医学部, 助教授 (40273148)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2002: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | acute coronary syndrome / fibrinolytic system / α2-antiplasmin / vascular endothelial growth factor / 肺性心 |
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| Research Abstract |
We investigated the role of fibrinolyitc system in ischemic diseases. We obtained the results as follows:
1.Lack of α2-antiplasmin decreases survival ratio after acute myocardial infarction. This phenomenon is due to mainly to the alteration of vascular permeability via an over-release of vascular endothelial growth factor (VEGF) as a result of the exaggerated activity of plasmin no longer tempered by α2 -antiplasmin.
2.Lack of α2-antiplasmin improves the vascular patency after endothelial injury which is mainly because of the enhancement of endothelial cell healing via an over-release of VEGF.
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