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Studies on Selective Imaging of Coronary Territories Using Intravenous Myocardial Contrast Echocardiography

Research Project

Project/Area Number 14570667
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKagawa University, Faculty of Medicine

Principal Investigator

OHMORI Koji  Kagawa University, Faculty of Medicine, University Hospital, Lecturer, 医学部附属病院, 講師 (00263913)

Co-Investigator(Kenkyū-buntansha) KOHNO Masakazu  Kagawa University, Faculty of Medicine, Professor, 医学部, 教授 (20153489)
MIZUSHIGE Katsufumi  Kagawa University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (90166009)
MASUGATA Hisashi  Kagawa University, Faculty of Medicine, University Hospital, Assistant Professor, 医学部附属病院, 助手 (70263910)
YUKIIRI Kazushi  Kagawa University, Faculty of Medicine, University Hospital, Assistant Professor, 医学部附属病院, 助手 (30346647)
高木 雄一郎  香川大学, 医学部附属病院, 助手 (20346646)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2003: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2002: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordsmicrobubble / ultrasound / continuous wave Doppler / cross-talk / capillary vessels / microhemorrhage / angiogenesis / laukocvtes / 連続波ドプラ / 生体反応 / 炎症 / 左冠動脈主幹部 / 心筋コントラストエコー / elastic modulus / 流速 / パワーハーモニックドプラ法
Research Abstract

We clarified the relationship between the fragility of microbubble shell and the range of blood flow velocity in destroying the microbubbles regarding the completeness of destruction in a flow model study. In patients study, we propose to evaluate the left (LCA) and right coronary (RCA) territories separately in a session, because the entire myocardial segments are rarely opacified at one time. Microbubble destruction and replenishment principle was useful to determine the severity of coronary stenosis. In dog experiments, we visualized the left main coronary trunk (LMT) on a short axis image of aortic root while the short axis view or the long axis view of the left ventricle was visualized with another transducer. Insonation of LMT with continuous wave Doppler mode for the microbubble destruction and low power pulse inversion harmonic mode (real-time imaging) for perfusion imaging during infusion of BR1 was suitable to obtain appreciable images while microbubble destruction significantly affected the signal intensity in LCA territory. However, problems remained unsolved ; the only microbubble clinically available Levovist is too fragile and is not suitable for real-time imaging, and technical issue to handle two transducers simultaneously in a limited echo window.
We further studied the safeness of microbubble destruction. We found that destruction of microbubbles in a microcirculation causes capillary rupture resulting in microhemorrhage leading to local infiltration of leukocytes. Then, we further studied this phenomena and found that microbubbles attach to the activated leukocytes and are phagocytosed, which provided the basis for ultrasonic imaging of inflammation. In addition, we found that thus recruited leukocytes (macrophages) produce vascular endothelial growth factor, thereby enhance angiogenesis.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (22 results)

All 2004 2003 Other

All Journal Article (16 results) Publications (6 results)

  • [Journal Article] Leukocyte-targeted myocardial contrast echocardiography can assess the degree of acute allograft rejection in a rat cardiac transplantation model2004

    • Author(s)
      Kondo I
    • Journal Title

      Circulation 109・8

      Pages: 1056-1061

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Interaction with leukocytes : phospholipid-stabilized versus albumin-shell microbubbles2004

    • Author(s)
      Takeuchi H
    • Journal Title

      Radiology 230・3

      Pages: 735-742

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] A comparison of video and digital data in the assessment of myocardial perfusion abnormalities by myocardial contrast echocardiography.2004

    • Author(s)
      Masugata H, Yukiiri K, Takagi Y, Ohmori K, Mizushige K, Kohno M
    • Journal Title

      Int J Cardiovasc Imaging 20(3)

      Pages: 203-211

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Potential pitfalls of visualization of myocardial perfusion by myocardial contrast echocardiography with harmonic gray scale B-mode and power Doppler imaging.2004

    • Author(s)
      Masugata H, Yukiiri K, Takagi Y, Ohmori K, Mizushige K, Kohno M
    • Journal Title

      Int J Cardiovasc Imaging 20(2)

      Pages: 117-125

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Leukocyte-targeted myocardial contrast echocardiography can assess the degree of acute allograft rejection in a rat cardiac transplantation model.2004

    • Author(s)
      Kondo I, Ohmori K, Oshita A, Takeuchi H, Yoshida J, Shinomiya K, Fuke S, Suzuki T, Mizushige K, Kohno M
    • Journal Title

      Circulation 109(8)

      Pages: 1056-1061

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Interaction with leukocytes : phospholipid-stabilized versus albumin-shell microbubbles2004

    • Author(s)
      Takeuchi H, Ohmori K, Kondo I, Shinomiya K, Oshita A, Takagi Y, Yoshida J, Mizushige K, Kohno M
    • Journal Title

      Radiology 230(3)

      Pages: 735-742

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Difference of optimal dose of contrast agent between gray-scale and power Doppler imaging in assessing graded coronary stenosis by myocardial contrast echocardiography2003

    • Author(s)
      Masugata H
    • Journal Title

      Investigative Radiology 38・9

      Pages: 550-558

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Assessment of right ventricular perfusion after right coronary artery occlusion by myocardial contrast echocardiography2003

    • Author(s)
      Masugata H
    • Journal Title

      Journal of the American College of Cardiology 14・10

      Pages: 1823-1830

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Effect of microbubble fragility on transit rate measurement by contrast echography2003

    • Author(s)
      Ohmori K
    • Journal Title

      Ultrasound Med Biol 29・2

      Pages: 271-276

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 白血球とバブルの相互作用とその応用2003

    • Author(s)
      近藤 功
    • Journal Title

      超音波医学 30・4

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Contrast transesophageal echocardiography in diagnosing congenital enlargement of the right atrium--a case report.2003

    • Author(s)
      Yukiiri K, Mizushige K, Ohmori K, Wada Y, Tanimoto K, Ueda T, Takagi Y, Kohno M
    • Journal Title

      Angiology 54(5)

      Pages: 619-623

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Difference of optimal dose of contrast agent between gray-scale and power Doppler imaging in assessing graded coronary stenosis by myocardial contrast echocardiography.2003

    • Author(s)
      Masugata H, DeMaria AN, Peters B, Lafitte S, Strachan GM, Kwan OL, Ohmori K, Mizushige K, Kohno M
    • Journal Title

      Invest Radiol 38(9)

      Pages: 550-558

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Quantitative assessment of coronary stenosis by harmonic power Doppler with a simple pulsing sequence and vasodilator stress in patients.2003

    • Author(s)
      Takagi Y, Ohmori K, Yukiiri K, Kondo I, Yu Y, Oshita A, Takeuchi H, Mizushige K, Kohno M
    • Journal Title

      J Am Coll Cardiol 41(11)

      Pages: 2060-2067

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Assessment of right ventricular perfusion after right coronary artery occlusion by myocardial contrast echocardiography.2003

    • Author(s)
      Masugata H, Fujita N, Kondo I, Peters B, Ohmori K, Mizushige K, Kohno M, DeMaria AN
    • Journal Title

      J Am Coll Cardiol 41(10)

      Pages: 1823-1830

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Effect of microbubble fragility on transit rate measurement by contrast echography.2003

    • Author(s)
      Ohmori K, DeMaria AN, Cotter B, Kwan OL, Oshita A, Kondo I, Mizushige K, Kohno M
    • Journal Title

      Ultrasound Med Biol 29(2)

      Pages: 271-276

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Microbubble interactions with activated leukocytes.2003

    • Author(s)
      Kondo I, Ohmori K, Mizushige K
    • Journal Title

      J Med Ultrasonics 30(4)

    • NAID

      10011692405

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kondo I: "Leukocyte-targeted myocardial contrast echocardiography can assess the degree of acute allograft rejection in a rat cardiac transplantation model"Circulation. 109・8. 1056-1061 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takeuchi H: "Interaction with leukocytes : phospholipid-stabilized versus albumin-shell microbubbles"Radiology. 230・3. 735-742 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Masugata H: "Difference of optimal dose of contrast agent between gray-scale and power Doppler imaging in assessing graded coronary stenosis by myocardial contrast echocardiography"Investigative Radiology. 38・9. 550-558 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Masugata H: "Assessment of right ventricular perfusion after right coronary artery occlusion by myocardial contrast echocardiography"Journal of the American College of Cardiology. 14・10. 1823-1830 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yuichiro Takagi, Koji Ohmori, et al.: "Quantitative Assessment of Coronary Stenosis by Harmonic Power Doppler with a Simple Pulsing Sequence and Vasodilator Stress in Patients"Journal of the American College of Cardiology. Vol41(in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Koji Ohmori, Isao Kondo, et al.: "Effect of Microbubble Fragility on Transit Rate Measurement by Contrast Echography"Ultrasound in Medicine and Biology. Vil29(in press). (2003)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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