| Project/Area Number |
14570668
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | EHIME UNIVERSITY |
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Principal Investigator |
KOHARA Katsuhiko Ehime University, School of Medicine, Associate professor, 医学部, 助教授 (30260384)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2003: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2002: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | Chlamydia pneumoniae / chronic infection / seropositivity / adhesion molecule / chemokine / oxidative stress / susceptible gene / angiotensinogen / MTHFR / GS蛋白αサブユニット / 一塩基多型 / 環境因子・遺伝因子相互作用 / 動脈硬化 / 疾患感受性遺伝子 / 関連研究 / ゲノムワイド・スクリーニング / マイクロサテライトマーカー |
|---|
| Research Abstract |
Chronic and persistent infection a risk factor for atherosclerosis has been the focus of research. In particular, Chlamydia pneumoniae(Cp), has attracted so much attention that several clinical trials using antimicrobial drugs have been carried out. Although infection and activation of vascular endothelium by micropathogen is one of main underlying mechanisms, the mechanisms how the infection turns out to persist in certain patients after pulmonary airways infections remains to be determined. Three major results were obtained in the present study : (1)Cp seropositivity showed a significant positive associations with soluble adhesion molecules, ICAM-1 and VCAM-1,as well as chemokines MCP1 concentration, (2)Cp seroposivity significantly associated with systemic oxidative stress expressed with urinary concentration of 8-epi PGF2 alfa, and (3)Cp seropositivity was significantly associated with M235T angiotensinogen gene polymorphisms. These findings provide useful information for the comprehensive understanding about the mechanisms linking Cp infection and atherosclerosis.
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