| Project/Area Number |
14570710
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
KISHIMOTO Ichiro National Cardiovascular Center Research Institute, Head of Biochemistry, 生化学部, 室長 (80312221)
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Yoshihiro Kyoto University, Department of Medicine and Clinical Science, Assistant Professor, 医学部・研究科, 助手 (70291424)
SAITO Yosihiko Nara Medical University, First Department of Internal Medicine, Professor, 第1内科学教室, 教授 (30250260)
KANAGAWA Kenji National Cardiovascular Center Research Institute, Director of Biochemistry, 生化学部, 部長 (00112417)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2002: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | myocardial infarction / natriuretic peptides / remodeling / fibrosis / angiogenesis / hypertrophy / 心臓リモデリング |
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| Research Abstract |
We assessed the hypothesis that the in vivo administration of C-type natriuretic peptide (CNP) might attenuate cardiac late remodeling after myocardial infarction (MI). When CNP was intravenously infused for 2 weeks in rats with MI, the left ventricular enlargement and dysfunction caused by MI were improved by CNP. CNP significantly attenuated an increase in morphometrical collagen volume fraction in the non-infarct region and improved capillary density. The increases of collagen I, collagen III, atrial natriuretic peptide, and β-myosin heavy chain mRNA levels in the non-infarct region were also suppressed by CNP. In conclusion, CNP might be useful as a novel cardioprotective agent.
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