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Dynamic conical conformal radiotherapy using a C-arm mounted accelerator and its treatment planning software

Research Project

Project/Area Number 14570839
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionThe University of Tokyo

Principal Investigator

NAKAGAWA Keiichi  The University of Tokyo, Faculty of Medicine, Associate Professor, 医学部附属病院, 助教授 (80188896)

Co-Investigator(Kenkyū-buntansha) ONOGI Yuzo  The University of Tokyo, Faculty of Medicine, Associate Professor, 医学部附属病院, 助教授 (90233593)
TERAHARA Atsuro  The University of Toho, Radiology, Assistant Professor, 医学部附属病院, 助教授 (80237007)
TAGO Masao  The University of Tokyo, Faculty of Medicine, Lecturer, 医学部附属病院, 講師 (50282520)
NAKAMURA Naoki  The University of Tokyo, Faculty of Medicine, Research Associate, 医学部附属病院, 助手 (40359625)
NAKANISHI Tetsuya  Mitsubishi Electric Corporation, Chief Researcher, 主任研究員
青木 幸昌  国際医療福祉大学, 放射線情報学科, 教授 (40143474)
依田 潔  三菱電機先端総合研究所, 研究員
Project Period (FY) 2002 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2004: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2003: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2002: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsC-arm linac / conformal radiotherapy / Dyconic CRT / 3D-CRT / RTP / Cアーム型ライナック / 治療計画 / 放射線治療 / 3次元歳差集光原体照射療法
Research Abstract

The aim of the study was to improve dose distribution with rotational conformal radiotherapy (RCRT) using a C-arm mounted accelerator. The linac head was designed to move along the C-arm with a maximum angle of 60 degrees (from a vertical position toward the gantry). Simultaneous rotation of the gantry creates a dynamic conical irradiation technique. Dynamic conical conformal radiation therapy (Dyconic CRT) was developed by combining the technique with continuous motion of multi-leaf collimator (MLC). Dose distributions were measured in phantoms using film densitometry and compared with conventional RCRT. Dose distributions in actual radiation therapy patients are also presented. Dyconic CRT actualized precise non-coplanar beam entry without table rotation. In addition, a specialized treatment planning software for Dyconic CRT was completed on a commercially available RTP computer. The measurements showed that three-dimensionally proportional dose gradient was achieved with Dyconic CRT, when compared to that with conventional RCRT. Dose in homogeneity in the sagittal direction with Dyconic CRT was compensated by use of 30-degree wedge. Drawback of RCRT in dose distribution was overcome with the present technique.

Report

(4 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (29 results)

All 2004 2003 Other

All Journal Article (15 results) Patent(Industrial Property Rights) (2 results) Publications (12 results)

  • [Journal Article] Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer.2004

    • Author(s)
      Hosoi Y, Watanabe T, Nakagawa K他
    • Journal Title

      Int J Oncol 25

      Pages: 461-468

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Steep Elevation of Blood IL-6 Associated with Only Late Stages of Cachexia in Cancer Patients.2004

    • Author(s)
      Satoru Iwase, Keichi Nakagawa 他
    • Journal Title

      The European Cytokine Network 15

      Pages: 312-316

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Gamma knife radiosurgery for hemangioblastomas.2004

    • Author(s)
      Tago M, Terahara A, Nakagawa K, 他
    • Journal Title

      J Neurosurg (Suppl)102

      Pages: 171-174

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer.2004

    • Author(s)
      Hosoi Y, Watanabe T, Nakagawa K, Matsumoto Y, Enomoto A, Morita A, Nagawa H, Suzuki N
    • Journal Title

      Int J Oncol 25

      Pages: 461-468

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Steep Elevation of Blood IL-6 Associated with Only Late Stages of Cachexia in Cancer Patients.2004

    • Author(s)
      Satoru Iwase, Tadashi Murakami, Yuichiro Saito, Keichi Nakagawa.
    • Journal Title

      The European Cytokine Network 15

      Pages: 312-316

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Gamma knife radiosurgery for hemangioblastomas.2004

    • Author(s)
      Tago M, Terahara A, Shin M, Maruyama K, Kurita H, Nakagawa K, Ohtomo K
    • Journal Title

      J Neurosurg (Suppl) 102

      Pages: 171-174

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer.2004

    • Author(s)
      Hosoi Y, Watanabe T, Nakagawa K 他
    • Journal Title

      Int J Oncol 25

      Pages: 461-468

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Steep Elevation of Blood IL-6 Associated with Only Late Stages of Cachexia in Cancer Patients.2004

    • Author(s)
      Satoru Iwase, Tadashi Murakami, Yuichiro Saito, Keichi Nakagawa
    • Journal Title

      The European Cytokine Network 15

      Pages: 312-316

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Gamma knife radiosurgery for hemangioblastomas.2004

    • Author(s)
      Tago M, Terahara A, Shin M, Maruyama K, Kurita H, Nakagawa K
    • Journal Title

      J.Neurosurg 102(Suppl)

      Pages: 171-174

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Current status and future prospects of radiation therapy and medical accelerator.2004

    • Author(s)
      Nakagawa Keiichi, et al.
    • Journal Title

      Proceedings of the 1st annual meeting of particle accelerator society of Japan

      Pages: 25-29

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer.2004

    • Author(s)
      Hosoi Y, Watanabe T, Nakagawa K, Matsumoto Y 他
    • Journal Title

      Int J Oncol 25

      Pages: 461-468

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Intercomparison of Dose Distribution between Gamma Knife and C-arm-mounted LINAC2003

    • Author(s)
      Keiichi Nakagawa, Masao Tago 他
    • Journal Title

      Radiation Medicine vol 21, no4

      Pages: 178-182

    • NAID

      10013917728

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Dynamic Conical Conformal Radiotherapy sing A C-Arm Mounted Accelerator : Dose Distribution And Clinical Application.2003

    • Author(s)
      Keiichi Nakagawa, Yukimasa Aoki 他
    • Journal Title

      International Journal of Raciation Oncology, Biology, Physics 56

      Pages: 287-295

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Intercomparison of Dose Distribution between Gamma Knife and C-arm-mounted LINAC2003

    • Author(s)
      Keiichi Nakagawa, Masao Tago, Kouji Shibata, Naoki Nakamura, Hideomi Yamashita, Atsuro Terahara, Kuni Ohtomo
    • Journal Title

      Radiation Medicine. vol 21, no4

      Pages: 178-182

    • NAID

      10013917728

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Dynamic Conical Conformal Radiotherapy sing A C-Arm Mounted Accelerator : Dose Distribution And Clinical Application.2003

    • Author(s)
      Keiichi Nakagawa, Yukimasa Aoki, Masao Tago, Kuni Ohtomo
    • Journal Title

      International Journal of Radiation Oncology, Biology, Physics 56

      Pages: 287-295

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 特許2004

    • Inventor(s)
      中川 恵一
    • Industrial Property Number
      2004-356062
    • Filing Date
      2004-12-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 特許2004

    • Inventor(s)
      中川恵一
    • Industrial Property Number
      2004-356062
    • Filing Date
      2004-12-08
    • Related Report
      2004 Annual Research Report
  • [Publications] Yasuhiro Komuro et al.: "Prediction of tumor radiosensitivity in rectal carcinoma based on p53 and ku70 expression"Journal of Experimental & Clinical Cancer Research. 22. 223-228 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Shin Takizawa et al.: "Abnormal Fhit expression is an independent poor prognostic factor for cervical cancer"British Journal of Cancer. 88. 1213-1216 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Keiichi Nakagawa et al.: "Dynamic Conical Conformal Radiotherapy sing A C-Arm Mounted Accelerator : Dose Distribution And Clinical Application"International Journal of Radiation Oncology, Biology, Physics. 56. 287-295 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hidemasa Takao et al.: "Central Neurocytoma with Craniospinal Dissemination"Journal of Neuro Oncology. 61(3). 255-259 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Keiichi Nakagawa et al.: "Intercomparison of Dose Distribution between Gamma Knife and C-arm-mounted LINAC"Radiation Medicine. 21(4). 178-182 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Koike Y et al.: "Factors affecting the prognosis of patients with hepatocellular carcinoma invading the portal vein-a retrospective analysis using 952 consecutive NCC patient"Hepatogastroenterology. 50(54). 2035-2039 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yasuhiro Komuro et al.: "The expression pattern of ku correlates with tumor radiosensitivy and disease free survival in patients with rectal carcinoma"CANCER. 95. 1199-1205 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Hosoi et al.: "Phosphorothioate oligonucleotides, suramin and heparin inhibit DNA-dependent protein kinase activity"British Journal of Cancer. 86. 1143-1149 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] M.Yoshida et al.: "Roles of DNA-dependent protein kinase and ATM in cell-cycle depedent radiation sensitivity in human cells"International Journal of Radiation Biology. 78(6). 503-512 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] S.Aoki et al.: "Radiation-induced arteritis : thickened wall with prominent enhancement on cranial MR images report of five cases and comparison with 18 cases of moyamoya disease"Radiology. 223(3). 683-688 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] N.Nakamura et al.: "Gamma knife radiosurgery for cavernous hemangiomas in the cavernous sinus. Report of three cases"J Neurosurg. 97. 477-480 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 中川恵一: "三次元放射線治療計画法 癌・放射線療法"篠原出版新社. 1095 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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