| Project/Area Number |
14570850
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Mie University |
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Principal Investigator |
TAKEDA Kan Mie University, Faculty of Medicine, Professor, 医学部, 教授 (70106988)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMURA Kaname Mie University, University Hospital, Clinical Staff, 医学部附属病院, 診療等従事者 (70126994)
SAKUMA Hajime Mie University, University Hospital, Associate Professor, 医学部附属病院, 助教授 (60205797)
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| Project Period (FY) |
2002 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2004: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2003: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | I-123 BMIPP / ischemic heart disease / myocardial damage induced by anti-cancer drug / dynamic SPECT / Rutland analysis / I-123BMIPP / 抗がん剤による心筋障害 / dynamic SPECT / 心筋脂肪酸代謝 / taxane / 抗癌剤による心筋薬物療法 |
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| Research Abstract |
Fatty acid metabolic disorder was assessed in ischemic myocardium and myocardial damage induced by anti-cancer drug using I-123 beta-metyl-idophenyl-pentadecanoic acid(BMIPP) dynamic SPECT data with analysis by the Rutland method. Dynamic SPECT data were obtained after bolus injection of I-123 BMIPP using 3-head SPECT system. On analysis of the obtained data by the Rutland method, uptake constant of BMIPP (K value) and the time when the excretion of BMIPP from the myocardium began (Tex) were calculated. Informed consents were obtained in all patients.
1)In ischemic myocardium, K values were significantly decreased and Tex was strikingly shortened as compared with the normal myocardium. In Doxorubicin-induced myocardial damage, by contrast, K values were considerably decreased but Tex was significantly prolonged in comparison with the normal myocardium. These results suggested that the main cause of fatty acid metabolism was increased back diffusion in ischemic myocardium, but decreased metabolic rate of fatty acid in Doxorubicin-induced myocardial damage.
2)Same assessment was performed in another anti-cancer drug, Taxane. Myocardial BMIPP SPECT images were impaired and K values were significantly decreased after administration of Taxane. These fatty acid metabolic disorders were detected before the appearance of functional impairment of left ventricle. Thus, these methods are promising in early detection of myocardial damage induced by anti-cancer drugs.
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