| Project/Area Number |
14570854
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
MATSUDA Tetsuya Kyoto University, Graduate School of Informatics, Professor, 情報学研究科, 教授 (00209561)
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| Co-Investigator(Kenkyū-buntansha) |
SUGA Mikio Nara Institute of Science and Technology, Graduate School of Information Science, Research Associate, 情報科学研究科, 助手 (00294281)
MINATO Kotaro Nara Institute of Science and Technology, Graduate School of Information Science, Professor, 情報科学研究科, 教授 (00127143)
MIZUTA Shinobu Kyoto University, Graduate School of Informatics, Research Associate, 情報学研究科, 助手 (40314265)
AMANO Akira Kyoto University, Graduate School of Informatics, Assistant Professor, 情報学研究科, 助教授 (60252491)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2002: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | Magnetic Resonance Elastography / high-speed MRI / phase contrast method / oscillation system / preparation pulse |
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| Research Abstract |
Magnetic resonance elastography (MRE) can provide quantitative measurements of tissue elasticity by visualizing the strain waves applied from the body surface. Though MRE is expected to be a powerful diagnostic tool for tissue characterization, its long acquisition time limits the practical application to the area such as brain, extremities, and breast, where respiratory motion was not necessarily considered. To realize in vivo measurement of tissue elasticity in human abdomen, we aimed to develop a high speed MRE acquisition method by introducing our original technique of phase velocity encoding that could be combined with various high speed MR imaging methods as preparation pulses. The technique translated the velocity encoded phase shift into the longitudinal magnetization and the velocity information was retrieved from the signal intensity after the image acquisition. In this research project, we also designed an oscillation system that generates strain waves appropriate to calculate the elasticity from the acquired images.
Introduction of our original technique of phase velocity encoding to a high speed MR imaging method successfully acquired MRE images during a single breath-hold period. The oscillation system we proposed in this research project was a bed-type oscillator on which patients rested. We constructed a prototype of table oscillator and MRE images obtained from an elastic phantom on the table oscillator demonstrated that flat strain waves were generated. Since pure transverse waves were generated independently from longitudinal wave components, shear modulus of the phantom could be calculated from the obtained MRE images without contamination of Young' s modulus. While tissue elasticity of abdominal organ has not been obtained yet, essential methodology for abdominal MRE was established in this research project.
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