| Project/Area Number |
14570860
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
SUGA Kazuyoshi YAMAGUCHI UNIVERSITY, HOSPITAL, ASSOCIATED PROFESSOR, 医学部附属病院, 助教授 (90171115)
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| Co-Investigator(Kenkyū-buntansha) |
FUJITA Takeshi YAMAGUCHI UNIVERSITY, SCHOOL OF MEDICINE, RESEARCH ASSOCIATE, 医学部, 助手 (50335733)
ITO Katsuyoshi YAMAGUCHI UNIVERSITY, HOSPITAL, ASSISTANT PROFESSOR, 医学部附属病院, 講師 (00274168)
MATSUNAGA Naofumi YAMAGUCHI UNIVERSITY, SCHOOL OF MEDICINE, PROFESSOR, 医学部, 教授 (40157334)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2003: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2002: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | Magnetic resonance imaging / Pulmonary perfusion / Pulmonary embolism / Pulmonary ventilation / Bronchial obstruction / Electrocardiogram / Lung / 気道閉塞 / 心電図同期 / 肺〓栓症 / 気道閉〓 |
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| Research Abstract |
In animal study, a non-contrast ECG-gated perfusion MR study Has performed in airway obstruction (AO) and degradable starch microsphere (spherex)-induced temporal microvascular pulmonary embolic (PE) dogs, with a combination study of dynamic Gd-DTPA images. The ECG-gated perfusion weighted images were obtained by subtraction between two-phase images of the minimum lung signal intensity during cardiac systole and maximum signal intensity during diastole. The ECG-gated perfusion-weighted images showed gradual disappearance of the spherex-induced perfusion deficits, and showed the dynamically decreased perfusion with tine after bronchial occlusion in all the airway obstruction models. These findings were consistent with Gd-DTPA-enhanced pulmonary arterial perfusion phase images. These results indicate that a non-contrast ECG-gated perfusion MR imaging may leave excellent potential for continuously monitoring dynamically changed regional lung perfusion within a short time
Clinically, a non-
… More
contrast ECG-gated perfusion MR imaging was performed in 9 healyhy volunteers, 11 patients with pulmonary artery-occlusive diseases and 15 patients with clvonic obstructive pulmonary diseases, with a combination study of Tc-99m-MAAA perfusion single photon emission computed tomography (SPELT) images. The non-contrast ECG-gated perfusion MR images slowed uniform hilt posture-dependent perfusion gradient in normal lungs and visualized the various sizes of perfusion defects in diseased lungs. These defect sites were nearly consistent with those on perfusion SPELT images. These results indicate that the non-contrast ECG-gated perfusion MR image can be an attractive non-invasive fool for qualitative and quantitative assessment of regional perfusion impairment
During these studies, we also developed Gd-DTPA aerosol MR imaging which can be available for assessment of alveolar epitheilar permeability in bleomycin-injured lungs. All these result innovative findings inhere published in English journals Less
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