| Project/Area Number |
14570861
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
FUKUMOTO Tetsuo Yamaguchi University, School of Medicine, Professor, 医学部, 教授 (00040171)
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| Co-Investigator(Kenkyū-buntansha) |
EBE Kazuyu Yamaguchi University, University Hospital, Assistant Professor, 医学部附属病院, 講師 (90213579)
TOKUDA Nobuko Yamaguchi University, School of Medicine, Research Associate, 医学部, 助手 (70227578)
SAWADA Tomoo Yamaguchi University, School of Medicine, Assistant Professor, 医学部, 講師 (90187295)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2003: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2002: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | thymic epithelial cells / thymus / irradiation / immnohistochemistry / RT-PCR / cytokines / CD4, CD8 / MHC / 胸腺細胞 / フローサイトメトリー |
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| Research Abstract |
Rats were irradiated at the dotes of 6Gy or 8Gy. Thymus weights reduced after irradiation and recovered rapidly within 2 to 3 days after irradiation in the case of 6Gy irradiation, while in the 8Gy irradiation thymus recovery were retarded and started to recover on day 7 to 11 after irradiation. Subsequent recovery was up to 65% of control rat thymus. The mechanisms responsible for abrupt thymus weight were analysed immunohistochemically and by RT-PCR analysis on several cytokines, suggesting cytokine changes were intimately related to the thymic recovery
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