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Effects of cognitive rehabilitation for mild cognitive impairment (MCI)

Research Project

Project/Area Number 14570904
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionTohoku University

Principal Investigator

MEGURO Kenichi  Tohoku University, Graduate School of Medicine, Research Associate, 大学院・医学系研究科, 助手 (90239559)

Co-Investigator(Kenkyū-buntansha) ISHIZAKI Junichi  Tohoku University, HOSPITAL, Research Associate, 医学部附属病院, 助手 (50361085)
YAMAGUCHI Satoshi  Tohoku University, HOSPITAL, Research Associate, 医学部附属病院, 助手 (90312587)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2002: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsVery Mild dementia / MCI / Cognitive Rehabilitation / CDR 0.5 / CDR0.5
Research Abstract

Elderly subjects with mild memory impairment but not apparent dementia are the focus of early intervention trials. To examine the effects of structural psychosocial intervention as cognitive rehabilitation for elderly subjects with mild cognitive impairment (MCI), the experimental group (14 CDR 0.5 subjects) and the control group (11 CDR 0.5 subjects) were studied. Subjects with cerebrovascular disease as shown by magnetic resonance imaging (MRI) were excluded. The experimental group participated in activities in a day care-like setting once a week over a period of six months, while the control group did not. Each group was reevaluated after approximately 9 months. The effects of intervention were evaluated by cognitive tests, affective scales, a global clinical measure, an observation scale in the sessions, and a projective test. The experimental group showed a significant improvement on the word fluency test, while the control group showed a significant decline on the MMSE (Mini-Mental State Examination), the digit span, and the Trail Making-A test. The experimental group revealed significantly higher levels on the MMSE and the digit span compared with the control group after the 6-month intervention. A significant improvement was found for the global clinical measure, the observation scale, and the projective test in the experimental group after the intervention. After controlling the potential confounders (age, educational level, baseline cognitive and affective status) in a multiple regression analysis, the same results were found. We considered that psychosocial intervention had beneficial effects for subjects with very mild AD.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Ishizaki J, Meguro K, et al.: "Therapeutic psychosocial intervention for Elderly Subjects with very mild AD in a community : The tajiri project"Alzheimer Disease and Associated Disorders. 16(4). 261-269 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 目黒謙一, 石崎淳一: "地域における痴呆性高齢者の早期発見と心理社会的介入:田尻プロジェクト"GERONTOLOGY NEW HORIZON. 15(1). 49-58 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Meguro K, Constans JM, et al.: "Corpus Callosum Atrophy, White Matter Lesions, and Frontal Executive Dysfunction in Normal Aging and AD : The Tajiri project"International Psychogeriatrics. 15(1). 9-25 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hashimoto R, Meguro K, et al.: "Executive Dysfunction can explain word-list learning in very mild AD : The Tajiri project"Psychiatry and Clinical Neurosciences. 58(1). 54-60 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Meguro K, Ishii H, et al.: "Prevalence and cognitive performances of CDR 0.5 and MCI in Japan : The Tajiri project"Alzheimer Disease and Associated Disorders. 18(1). 3-10 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishizaki J, Meguro K, et al.: "Therapeutic Psychosocial Intervention for Elderly Subjects With Very Mild Alzheimer Disease in a Community : The Tajiri Project"Alzheimer Disease & Associated Disorders. 16(4). 261-269 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Meguro K, Ishizaki J.: "Early detection and psychosocial intervention for dementia in a community : The Tajiri Project"GERONTOLOGY NEW HORIZON. 15(1). 49-58 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Meguro K, Constans JM, et al.: "Corpus callosum atrophy, white matter lesions, and frontal executive dysfunction in normal aging and AD : the Tajiri Project"International Psychogeriatrics. 15(1). 9-25 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hashimoto R, Meguro K, et al.: "Executive dysfunction can explain word-list learning disability in very mild AD : the Tajiri project"Psychiatry and Clinical Neurosciences. 58(1). 54-60 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Meguro K, ishii H, et al.: "Prevalence and cognitive performances of CDR 0.5 and MCI in Japan : The Tajiri Project"Alzheimer Disease and Associated Disorders. 18(1). 3-10 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Meguro K, Constars JM, et al.: "Corpus Coilosum atrophy, white matter lesions, and frontal excutiue dysfunction in Normal Agly and AD : The Tajir Project"International Pstchagerrotrics. 15(1). 9-25 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hashimoto R, Meguro K, et al.: "Execute dysfunction can explain wnd-list learning in very mild AD : The Tajir Project"Psychiatry and clinical Neurosciences. 58(1). 54-60 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ishizaki J., Meguro K., et al.: "Therapeutic Psychosocial Intervention for Elderly Subjects with Very Mild Alzheimer Disease in a Community : The Tajiri Project"Alzheimer Disease Associated Disorders. 16,4. 261-629 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 目黒謙一, 石崎淳一: "地域における痴呆性高齢者の早期発見と心理社会的介入:田尻プロジェクト"GERONTOLOGY NEW HORIZON. 15,1. 48-58 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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