| Project/Area Number |
14570904
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Tohoku University |
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Principal Investigator |
MEGURO Kenichi Tohoku University, Graduate School of Medicine, Research Associate, 大学院・医学系研究科, 助手 (90239559)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIZAKI Junichi Tohoku University, HOSPITAL, Research Associate, 医学部附属病院, 助手 (50361085)
YAMAGUCHI Satoshi Tohoku University, HOSPITAL, Research Associate, 医学部附属病院, 助手 (90312587)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2002: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | Very Mild dementia / MCI / Cognitive Rehabilitation / CDR 0.5 / CDR0.5 |
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| Research Abstract |
Elderly subjects with mild memory impairment but not apparent dementia are the focus of early intervention trials. To examine the effects of structural psychosocial intervention as cognitive rehabilitation for elderly subjects with mild cognitive impairment (MCI), the experimental group (14 CDR 0.5 subjects) and the control group (11 CDR 0.5 subjects) were studied. Subjects with cerebrovascular disease as shown by magnetic resonance imaging (MRI) were excluded. The experimental group participated in activities in a day care-like setting once a week over a period of six months, while the control group did not. Each group was reevaluated after approximately 9 months. The effects of intervention were evaluated by cognitive tests, affective scales, a global clinical measure, an observation scale in the sessions, and a projective test. The experimental group showed a significant improvement on the word fluency test, while the control group showed a significant decline on the MMSE (Mini-Mental State Examination), the digit span, and the Trail Making-A test. The experimental group revealed significantly higher levels on the MMSE and the digit span compared with the control group after the 6-month intervention. A significant improvement was found for the global clinical measure, the observation scale, and the projective test in the experimental group after the intervention. After controlling the potential confounders (age, educational level, baseline cognitive and affective status) in a multiple regression analysis, the same results were found. We considered that psychosocial intervention had beneficial effects for subjects with very mild AD.
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