| Project/Area Number |
14570905
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Tohoku University |
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Principal Investigator |
AWATA Shuichi Tohoku University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 (90232082)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Kazumasa Tohoku University, Hospital, Research Associate, 医学部附属病院, 助手 (20312572)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2003: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2002: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | Depression / Middle-aged and elderly / intractable / Electroconvulsive-therapy / Continuation ECT / Response Rate / Remission Rate / Comprehensive treatment system / 地域医療システム / 難治性重症うつ病 / 緊張型統合失調症 / 中高齢期 / 血管性うつ病 / 継続薬物療法 / 継続ECT |
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| Research Abstract |
In the intractable middle-aged and elderly depression, a course of acute ECT had more than 80% of short-term response rate, and about 50% of 6-month remission rate after ECT. In those patients with relapse within 6 months after ECT, a course of continuation ECT had about 50% of 6-month remission rate. Age was associated with neither short-term response rate nor 6-month remission rate. However, concurrent medical condition had tendency toward association with severity of residual symptoms after ECT. In the intractable middle-aged and elderly catatonic schizophrenia, a course of acute ECT had 100% of short-term response rate and less than 50% of 6-month remission rate after ECT. In those patients with relapse within 6 months after ECT, a course of continuation ECT had about 60% of 6-month remission rate.
Elderly depression and catatonia with medication resistance or intolerance are likely to have severe clinical features, often with life-threatened medical conditions and with highly relapse vulnerability after recovery from acute state. Thus, long-term comprehensive treatment strategy should be designed under the sufficient pathophysiological consideration. This study demonstrated the short-and long-term efficacy of the comprehensive treatment system which was located in a university hospital and dedicated for intractable elderly mental disorders in local medical facilities.
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