• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Neuropathological studies on the vulnerability to mood disorders and refractoriness to antidepressant treatment.

Research Project

Project/Area Number 14570909
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionGunma University

Principal Investigator

MIKUNI Masahiko  Gunma University, Neuropsychiatry, Professor, 医学部, 教授 (00125353)

Co-Investigator(Kenkyū-buntansha) MAJIMA Takehiko  Gunma University, Neuropsychiatry, Assistant, 医学部, 助手 (00312869)
IDA Itsuro  Gunma University, Neuropsychiatry, Instructor, 医学部, 講師 (50251103)
FUKUDA Masato  Gunma University, Neuropsychiatry, Associate Professor, 医学部, 助教授 (20221533)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2002: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywordsmood disorder / 18F-FDG-PET / DEX / CRH test / pre-frontal cortex / superior temporal gyrus / para-hippocampal gyrus / vulnerability / postmortem brain / 左前前頭前野 / 感情障害 / 発症脆弱性 / 死後脳 / 脳画像 / セロトニン2-A / 受容体 / 左前頭前野 / 右上側頭回 / 紡錘状回 / FDG-PET脳画像
Research Abstract

To clarify a neuronal vulnerability in primary mood disorder, we have investigated if cytoarchitectural alterations would be observed in the left prefrontal cortex, BA 9 in postmortem brain tissue from subjects with primary mood disorder, who were under long-term treatment with antidepressant and mood stabilizers. The left prefrontal cortex, BA 9 is documented to be one of the pathophysiological brain regions, and we have clearly demonstrated that the lowered glucose uptake activity was estimated by FDG-PET, in the left prefrontal cortex, BA 9, in depressive state-depended manner. Reduction in the density of small cell neurons has been observed in layer II, but not in I, III, IV in the left BA 9. There are no changes in glial density and large neuronal cell density in the left BA 9, although the decrease was observed through the depth of cortex of BA 9, compared with normal controls. Interestingly, the number of serotonin (5-HT)-2A receptor immunorecative cells was significantly increased in layer II, but not in I, III, IV in the left BA 9 in postmortem brain from subjects with primary mood disorder. The density of 5-HT-2A receptor binding sites is well-known to be down-regulated after subchronic administration of antidepressant agents in rat cerebral cortex. Therefore, the layer II in the left prefrontal cortex, BA 9 is of special interest in the vulnerability in primary mood disorder and refractoriness to antidepressant treatment.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Kameyama M, Fukuda M, Uehara T, Mikuni M: "Sex and age dependencies of cerebral blood volume changes during cognitive activation : A multichannel near-infrared spectroscopy study."NeuroImage. in press.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suto T, Fukuda M, Ito M, Uehara T, Mikuni M: "Multichannel near-infrared spectroscopy in depression and schizophrenia : cognitive brain activity study."Biological Psychiatry. 55. 501-511 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Okuyama-Tamura M, Mikuni M, Kojima I: "Modulation of the glucocorticoid receptor function by antidepressant compounds."Neuroscience Letter. 342. 206-210 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nemoto H, Toda H, Nakajima T, Hosokawa S, Konno Y, Yamamoto K, Horiuchi R, Inoue T, Endo K, Ida I, Mikuni M, Matsubara K, Goto F: "Regional cerebral blood flow in human antinociception with fluvoxamine."Neuroreport. 14. 2003 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Uehara T, Kazuo Takeuchi K, Ohmori I, Kawashima Y, Goto M, Mikuni M, Vandereycken W: "Factor analytic study of the Anorectic Behavior Observation Scale (ABOS) in Japan : comparisons with the original Belgian study."Psychiatry Research. 111. 241-246 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 三國 雅彦: "統合失調症治療ガイドライン 精神医学講座担当者会議監修 佐藤光源、井上新平編"医学書院. 180-186 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Uehara T, Ohmori T, Goto M, Kawashima Y, Moro H, Fukuda M, Mikuni M: "Eating disorders and family functioning - Relationships with diagnostic classifications, symptoms, and outocomes. In : Focus on Eating Disorders Research, edited by Pamela I.Swain"Nova Biomedical Books, New York. 135-150 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mikuni M, Kitera K, Muneoka K, Saitoh K, Yamazaki C, Majima T, Ida I, Watanabe Y: "Relationship between Vulnerability of Major Depressive Disorder and Prenatal Stress or Glucocorticoid Treatment. In : Recent Advances in the Research of Affective Disorder in Japan, ed.By Okuma T, Kanba S, Inoue Y"Elsevier Science. 43-49 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suto T, Fukuda M, Ito M, Uehara T, Mikuni M: "Multichannel near-infrared spectroscopy in depression and schizophrenia : cognitive brain activity study."Biological Psychiatry. 55. 501-511 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Okuyama-Tamura M, Mikuni M, Kojima I: "Modulation of the glucocorticoid receptor function by antidepressant compounds."Neuroscience Letter. 342. 206-210 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nemoto H, Toda H, Nakajima T, Hosokawa S, Konno Y, Yamamoto K, Horiuchi R, Inoue T, Endo K, Ida I, Mikuni M, Matsubara K, Goto F: "Regional cerebral blood flow in human antinociception with fluvoxamine."Neuroreport. 14. 791-797 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mikuni M, Kitera K, Muneoka K, Saitoh K, Yamazaki C, Majima T, Ida I, Watanabe Y: "Relationship between Vulnerability of Major Depressive Disorder and Prenatal Stress or Glucocorticoid Treatment. In : Recent Advances in the Research of Affective Disorder in Japan, ed. By Okuma T, Kanba S, Inoue Y"Elsevier Science. 43-49 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Uehara T, Kazuo Takeuchi K, Ohmori I, Kawashima Y, Goto M, Mikuni M, Vandereycken W: "Factor analytic study of the Anorectic Behavior Observation Scale (ABOS) in Japan comparisons with the original Belgian study."Psychiatry Research. 111. 241-246 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suto T, Fukuda M, Ito M, Uehara T, Mikuni M: "Multichannel near-infrared spectroscopy in depression and schizophrenia : cognitive brain activity study. Biological Psychiatry"Biological Psychiatry. 55. 501-511 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 三國 雅彦: "発症脆弱性の脳機能・器質因子"Clinical Neuroscience. 22. 147-150 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Okuyama-Tamura M, Mikuni M, Kojima I: "Modulation of the glucocorticoid receptor function by antidepressant compounds."Neuroscience Letter. 342. 206-210 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 福田正人, 上原 徹, 井田逸朗, 三國雅彦: "うつ病の新しい診断方法の開発"日本臨牀. 61. 1667-1682 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 福田正人, 伊藤 誠, 須藤友博, 亀山正樹, 山岸 裕, 上原 徹, 井田逸朗, 三國雅彦: "近赤外線スペクトロスコピー(NIRS)の臨床応用"分子精神医学. 3. 27(295)-40(308) (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 福田正人, 伊藤 誠, 須藤友博, 亀山正樹, 山岸 裕, 上原 徹, 井田逸朗, 三國雅彦: "新しい脳画像診断法の精神疾患への臨床応用-近赤外線スペクトロスコピーNIRS-"精神科. 3. 478-487 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Uehara T, Ohmori I, Goto M, Kawashima Y, Moro H, Fukuda M, Mikuni M: "Eating disorders and family functioning-relationships with diagnostic classifications, symptoms, and outcomes."Focus on Eating Disorders Research (Edited by Pamela I.Swain). 135-150 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Toru Uehara, Kazuo Takeuchi, Ichiro Ohmori, Yoshiaki Kawashima, Masahiro Goto, Masahiko Mikuni, Walter Vandereycken: "Factor analytic study of the Anorectic Behavior Observation Scale (ABOS) in Japan : comparisons with the original Belgian study"Psychiatry Research. 111. 241-246 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Miho Okuyama-Tamura, Masahiko Mikuni, Itaru Kojima: "Modulation of the glucocorticoid receptor function by antidepressant compounds.s."Neuroscience Letter. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Hidenori Nemoto, Hikaru Toda, Takashi Nakajima, Shin Hosokawa, Yuko Konno, Koujirou Yamamoto, Ryuya Horiuchi, Tomio Inoue, Keigo Endo, Itsuro Ida, Masahiko Mikuni, Kunio Matsubara, Fumio Goto: "Regional cerebral blood flow in human antinociception with fluvoxamine"Neuroreport. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Mikuni M, Kitera K, Muneoka K, Saitoh K, Yamazaki C, Majima T, Ida I, Watanabe Y: "Recent Advances in the Research of Affective Disorder in Japan"Elsevier. 43-49 (2002)

    • Related Report
      2002 Annual Research Report

URL: 

Published: 2002-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi