| Co-Investigator(Kenkyū-buntansha) |
AMANO Naoji Shinshu University, School of Medicine, Professor, 医学部, 教授 (10145691)
KANEKO Tomoki Shinshu University, School of Medicine, Assistant, 医学部, 助手 (40324256)
OOTA Setsuko Shinshu University, School of Medicine, Assistant, 医学部, 助手 (90143974)
SAKAI Ayako Shinshu University, School of Medicine, Assistant, 医学部, 助手
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2004: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2003: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2002: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Research Abstract |
<Introduction>We investigated the abnormality of brain volume on the oppositional defiant disorder (ODD) comorbid with the attention deficit hyperactivity disorder (ADHD) by the voxel-based morphometry (VBM). <Objects>Of the 【less than or equal】15 years old patients who visited the Shinshu University Hospital, between April 2002 and March 2005, those who fulfilled the criteria for ADHD or ODD according to DSM-IV were evaluated. The number of subjects was 12 (11 boys and 1 girl). Groupings were established : (1)the ADHD group, comprised patients with a diagnosis of ADHD alone (n=6), (2)the comorbid group, comprised of those with ADHD and ODD (n=6), and (3)the normal control (NC ; n=14). All the subjects and NC were right-handed. The socio-economic states of parents and the perinatal period complications didn't show significant differences between the subjects and NC. <Method>The MRI data were obtained by using 1.5T scanner (Simons). Image analysis was performed by using SPM99 software r
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unning in MATLAB 6.1. The statistical analysis was performed by the ANCOVA method that made the whole brain volume to be a covariance. Simultaneously, the mothers of all subjects and NC carried out filling up to the ADHD rating scale, ODD-scale, Oppositional defiant behavior inventory, and Eyberg child behavior inventory. <Results>(a)Group comparison ; (1)The ADHD group showed the significant volume decrease of the right fusiform gyrus, orbit frontal cortex, and caudate compared with NC. (2)The comorbid group showed the significant volume decrease of the right fusiform gyrus, orbit frontal cortex, vermis, superior temporal sulcus compared with NC. (3)There were no significant differences between volumes of any regions in the ADHD group and those in the comorbid group. (b)Correlation analysis ; (1)The volume of the right posterior cingulate significantly decreased, as the ADHD rating scale score increased in all the subjects. (2)The volume of the right superior temporal sulcus so did, as the ODD-scale score increased in all the subjects. <Conclusion>The right fusiform gyrus, orbit frontal cortex, and superior temporal sulcus, which showed volume decreases in the comorbid group, guessed to be concerned in the social recognition. It was suggested that the disturbance of social recognition seriously influenced processes that ODD comorbided with ADHD. Less
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