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Studies on serotonergic dysfunction in suicide

Research Project

Project/Area Number 14570923
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionKobe University

Principal Investigator

SHIRAKAWA Osamu  Kobe University, Graduate School of Medicine, Division of Psychiatry and Neurology, Associate Professor, 大学院・医学系研究科, 助教授 (40243307)

Co-Investigator(Kenkyū-buntansha) NUSHIDA Hideyuki  Kobe University, Graduate School of Medicine, Division of Legal Medicine, Instructor, 大学院・医学系研究科, 助手 (90335448)
UENO Yasuhiro  Kobe University, Graduate School of Medicine, Division of Legal Medicine, Professor, 大学院・医学系研究科, 教授 (30184956)
MAEDA Kiyoshi  Kobe University, Graduate School of Medicine, Division of Psychiatry and Neurology, Associate Professor, 大学院・医学系研究科, 教授 (80116251)
NISHIMURA Akiyoshi  Yokohama City University School of Medicine, Department of Legal Medicine, Associate Professor, 医学部, 助教授 (60283561)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2002: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywordssuicide / serononin / gene polymorphism
Research Abstract

We investigated the association of suicide with serotonin transporter promoter region (5HTT-LPR), dopamine receptor promoter region (DRD4), monoamine oxydase A promoter region (MAOA-uVNTR ) and catechol-O-methyltransferase (COMT) which could affect monoamine neurotransmission and might be related to temperament. Gene variants were determined using PCR-based techniques in 163 completed suicides and 169 controls. There were no statistical differences between completed suicides and controls in the genotypes and allelic distribution of 5HTT-LPR, MAOA-uVNTR and DRD4. We found that the genotype distribution of COMT between male suicide completers and malecontrols was significantly different. In addition, the G allele, high-activity allele showed a tendency to occur less frequently in male suicide completers. These results indicate that in male the high COMT activity could play an inhibitory role in suicide. We also investigated possible genetic interactions among these four polymorphisims. Significant interactions were observed in 5HTT-LPR x MAOA-uVNTR and 5HTT-LPR x COMT between male suicide completers and male controls. Further studies are needed to clarify the epistatic effects of these genes.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] Nishiguchi, N.: "Lack of an association between 5HT1A receptor gene structural polymorphisms and suicide victims"Am J Med Genet. 114. 423-425 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ono, H.: "No evidence of an association between a functional monoamine oxidase a gene polymorphism and completed suicides"Am J Med Genet. 114. 340-342 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ono, H: "Tryptophan hydroxylase immunoreactivity is altered by the genetic variation in postmortem brain samples of both suicide victims and controls"Mol.Psychiatry. 7. 1127-1132 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 白川治: "自殺者におけるセロトニン神経伝達系遺伝子多型"精神薬療研究年報. 34. 242-247 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ono, H.: "自殺と気質規定遺伝子との相関研究"精神薬療研究年報. 35. 88-92 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ono, H.: "Association between Catechol-O-Methyltransferase functional polymorphism and male suicide completers"Neuropsychopharmacology. (未定). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 白川 治: "自殺の予防 今日の治療指針(山口徹, 北原光夫編)"医学書院. 1169 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nishiguchi, N.: "Lack of an association between 5HT1A receptor genes structural polymorphisms and suicide victims"Am J Med Genet. 114(4). 423-425 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ono, H.: "No evidence of an association between a functional monoamine oxidase a gene polymorphism and completed suicides."Am J Med Genet. 114(3). 340-342 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ono, H.: "Tryptophan hydroylase immunoreactivity is altered by the genetic variation in postmortem brain samples of both suicide victims andcontrols."Mol.Psychiatry. 7(10). 1127-1132 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shirakawa, O.: "Association Study between Temperament-related Functional Gene Polymorphisms and Completed Suicides"Ann.Rep.Mitsubishi Pharma Res.Found.. 35. 88-92 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ono, H.: "Association between Catechol-O-Methyltransferase Functional Polymorphism and Male Suicide Completers"Neuropsychopharmacology. (In press.). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 白川 治: "自殺と気質規定遺伝子との相関研究"精神薬療年報. 35. 88-92 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Aoyama, S: "A novel polymorphism in the coding region of the DAP-1 gene (hDLG and PSD-95 associated protein-1 gene) : analysis of association with schizophrenia"Psychiatry and Clinical Neurosciences. 57・5. 545-547 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kajimoto, Y: "Synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP) is expressed differentially in the nucleus accumbens of phencyclidine-treated rats and is increased in the nucleus accumbens of patients with schizophrenia"Neuropsychopharmacology. 28・10. 1831-1839 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 白川 治: "自殺の生物学的側面"ストレス科学. 17・4. 238-244 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 白川 治: "うつ病の最新治療 薬物療法の実際"CLINICAL NEUROSCIENCE. 22・2. 202-207 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 小野 久江: "自殺企図 その病理と予防・管理(樋口輝彦編)"永井書店. 10 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 白川 治: "自殺の予防 今日の治療指針(山口徹・北原光夫編)"医学書院. 2 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nishiguchi, N.: "Lack of an association between 5HT1A receptor gene s structural polymorphisms and suicide victims"Am J Med Genet. 114・4. 423-425 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 小野久江: "自殺者におけるセロトニン神経伝達系遺伝子多型"精神薬療基金研究年報. 34. 242-247 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ono H: "No evidence of an association between a functional monoamine oxidase a gene polymorphism and completed suicides"Mol. Psychiatry. 7・10. 1127-1132 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 白川 治: "自殺の生物学的側面と自殺予防"心と社会. 33・2. 34-40 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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