| Project/Area Number |
14570931
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kawasaki Medical School (2004)
Kyushu University (2002-2003) |
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Principal Investigator |
NAKAGAWA Akiko Kawasaki Medical School, Psychiatry, Associate professor, 医学部, 助教授 (70253424)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIURA Takashi Kyushu University Hospital, Clinical Radiology, Assistant, 大学病院, 助手 (40322747)
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| Project Period (FY) |
2002 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2004: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2003: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2002: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | obsessive-compilsive disorder / cognitive function / neuropsychological test / functional MRI / action-monitoring function / selective attention / Stroop test / caudate nucleus / 前頭眼窩面 / Stroop Test |
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| Research Abstract |
Recent functional neuroimaging and neuropsychological studies have implicated that frontal cortex and subcortical structures may play a substantial role in the pathophysiology of OCD. To identify the relationship between brain dysfunction and cognitive dysfunction, we examined the regional brain changes in OCD by using functional MRI (fMRI) while a cognitive task is being undertaken. Thirty-one patients with OCD and nineteen normal controls participated in the study. First, we compared their cognitive function by several neuropsychological tests. Then we examined them fMRI during the Chinese character version Stroop task that is strongly related with action-monitoring function. On all the neuropsychological tests, there were no significant differences between the two groups. In fMRI, both the two groups showed similar activation pattern. The patients, however, showed weaker activation than the normal controls in the right caudate nucleus than the normal controls. It was suggested that OC symptoms might be related to abnormal activation in the caudate nucleus, though we were not able to find neuropsychological deficits of OCD.
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