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Molecular biological study on the organic solvent dependence -its mechanism and treatment-

Research Project

Project/Area Number 14570939
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

FUKUI Kenji  Kyoto Prefectural University of Medicine, Psychiatry, Professor, 医学研究科, 教授 (50165263)

Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2003: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2002: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywordsorganic solvent / psychiatric dependence / mesolimbic DA system / synaptophysin / immunocytochemistry / molecularbiology / 免疫組織化学 / 有機溶剤依存 / シナプトフィジン / ラット / 中枢神経系
Research Abstract

Since psychiatric dependence induced by the abuse of organic solvent is deeply related with the dopamine transmission, the mechanism of synaptophysin acting as the infusion factor between synapse vesicle and cell membrane in the nerve terminals, was studied using the immunocytochemistry and blotting method. In acute toluene-treated rat, the synaptophysin-like immunoreactive density increased in the nerve cells such as the prefrontal cortex, temporal cortex and nucleus accumbens. This increment was also confirmed by morphometric analysis and blotting method.
In addition, the synaptophysin-like immunoreactive regions were closely distributed in the area of meso-limbic dopamine (A10) pathway, it was suggested that the synaptophysin might have a close relation with the mechanism of organic solvent psychiatric dependence.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (17 results)

All 2004 2003 Other

All Journal Article (13 results) Book (1 results) Publications (3 results)

  • [Journal Article] Pentazocine依存に認知療法的アプローチが有効であった1症例2004

    • Author(s)
      渡邉 明 他
    • Journal Title

      日本アルコール・薬物医学会雑誌 39

      Pages: 482-487

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 老年期アルコール関連障害の臨床像の変化と長期予後2004

    • Author(s)
      北林 百合之介 他
    • Journal Title

      老年精神医学雑誌 15

      Pages: 1028-1032

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] アルコール・覚せい剤などの薬物乱用2004

    • Author(s)
      北林 百合之介 他
    • Journal Title

      日本医師会雑誌 131

      Pages: 192-193

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 機能形態学からみた依存性薬物の神経毒性2004

    • Author(s)
      福居 顯二 他
    • Journal Title

      日本アルコール精神医学雑誌 11

      Pages: 43-51

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 薬物依存の組織化学所見2004

    • Author(s)
      土田 英人 他
    • Journal Title

      Clinical Neuroscience 22

      Pages: 651-655

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] A case report of Pentazocine dependence -a standpoint of the cognitive therapy-.2004

    • Author(s)
      Watanabe, A et al.
    • Journal Title

      Jap J Alcohol & Drug dependence 39(5)

      Pages: 482-487

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] The changes of clinical features and long-term prognosis in senile alcohol-related disorders.2004

    • Author(s)
      Kitabayashi, Y et al.
    • Journal Title

      Jap J Geriatric Psychiatry 15(9)

      Pages: 1028-1032

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Drug abuse of alcohol and amphetamines.2004

    • Author(s)
      Kitabayashi, Y et al.
    • Journal Title

      Nihon Ishikai Zasshi 131(12)

      Pages: 192-193

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Functional morphological survey of neurotoxicity induced by addictive substances.2004

    • Author(s)
      Fukui, K et al.
    • Journal Title

      Jap J Psychiatric Res on Alcohol 11(1)

      Pages: 43-51

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Histological changes in drug dependence.2004

    • Author(s)
      Tsuchida, H et al.
    • Journal Title

      Clinical Neuroscience 22(6)

      Pages: 651-655

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Advance of functional neuroimaging studies in substance abuse.2004

    • Author(s)
      Kitabayashi, Y et al.
    • Journal Title

      Jap J Biological Psychiatry 14(4)

      Pages: 299-303

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 物質乱用における脳機能画像研究の進歩2003

    • Author(s)
      北林 百合之介 他
    • Journal Title

      脳と精神の医学 14

      Pages: 299-303

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Drug Dependence2003

    • Author(s)
      Fukui, K
    • Journal Title

      TODAY'S THERAPY 2003

      Pages: 547-548

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Book] 今日の治療指針20032003

    • Author(s)
      福居 顯二
    • Total Pages
      1605
    • Publisher
      医学書院
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 土田英人, 北林百合之介, 横山ちひろ, 福居顯二: "薬物依存の組織化学"Clinical Neuroscience. (発表予定). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 北林百合之介, 上田英樹, 床山ちひろ, 福居顯二: "アルコール・覚せい剤などの薬物乱用"日本医師会雑誌特別号. (発表予定). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 福居顯二: "今日の治療指針2003「薬物依存」"医学書院. 647-648 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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