| Project/Area Number |
14570949
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Osaka Medical College |
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Principal Investigator |
KURODA Kenji Osaka Medical College, Faculty of Medicine, Associate Professor, 医学部, 助教授 (20170128)
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| Co-Investigator(Kenkyū-buntansha) |
HIMEI Akio Osaka Medical College, Faculty of Medicine, Research Associate, 医学部, 専攻医
NISHIDA Takehiko Osaka Medical College, Faculty of Medicine, Research Associate, 医学部, 助手 (80330091)
EMURA Narutsugu Osaka Medical College, Faculty of Medicine, Research Associate, 医学部, 助手 (20247860)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2002: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | Restless Legs Syndrome / Periodic Limb Movement / Sleep Disorders / Dopamine Agonist / Molecular Biology / Polysomnograph / Serotonin / Dopamine |
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| Research Abstract |
We have been treated patients suffering from many sleep disorders. A restless legs syndrome(RLS) is one of severe sleep disorders. Dopaminergic compounds such as L-DOPAs and dopamine receptor agonists are recommended to use the patints of RLS. Some causes of RLS are demonstrated but they are still under discussion. Recently genetic approaches have done by some researches in dopaminergic neuro-transmission system. However they couldn't define the relation of genetically inclusion. Still now we engaged a genetic research in psychiatric field, so we done an association study between serotonin receptor subtype (HT1A) polymorphism and sleep disorders. We couldn't detect a positive association. Now we have a small size of RLS patients, so we cannot show a statistical significance.
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