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Psychiatric symptoms as preceding or early signs of dementia of Alzheimer type. A cohort study.

Research Project

Project/Area Number 14570957
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionTokyo Metropolitan Organization for Medical Research

Principal Investigator

AKIYAMA Haruhiko (2004-2005)  Tokyo Metropolitan Organization for Medical Research, Tokyo Institute of Psychiatry, Research Director, 東京都精神医学総合研究所, 参事研究員 (20231839)

池田 研二 (2002-2003)  財団法人東京都医学研究機構, 東京都精神医学総合研究所, 参事研究員 (90232181)

Project Period (FY) 2002 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2005: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2004: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2003: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2002: ¥600,000 (Direct Cost: ¥600,000)
KeywordsAlzheimer's disease / Psychiatric symptoms / Hallucination and Delusion / Lewy body disease / 神経原線維変化 / 後部帯状回 / 神経原線維変化型痴呆 / アルツハイマー型痴呆 / 痴呆
Research Abstract

In total of 188 Alzheimer's disease (AD) patients (51 men and 137 women), who were admitted to Tokyo Metropolitan Matsuzawa Hospital, 13.1% of female patients and 2% of male patients had hallucination and/or delusion as early symptoms of the disease. The male patients also tended to have abnormal behavior or depression. Patients with AD type dementia, who show depression, hallucination or delusion as early symptoms, are often diagnosed neuropathologically as dementia with Lewy bodies (DLB). The vast majority of DLB patients had heavy accumulation of amyloid beta protein (Aβ) and neurofibrillary changes in the limbic cortices similarly to AD patients. On the other hand, those who do not fulfill the criteria for DLB and are, thus, diagnosed as AD, often have mild Lewy body pathology. It seems that the occurrence of psychiatric symptoms in dementia of AD type is related to the overlap between AD lesions and DLB lesions. However, thinking of these two diseases in a single entity or a group of diseases, a yet unsolved question is paucity of neurofibrillary changes in the neocortex of DLB, which seems to be unproportionate to the degree of Aβ deposits. In this study, we have demonstrated heavy accumulation of α-synuclein in the neuronal processes in the neocortex of DLB by immunohistochemistry of postmortem brain tissues from DLB patients using the antibodies to phosphorylated α-synuclein. Quantitative analyses have indicated that the amount of neuritic α-synuclein accumulation in DLB is comparable with that of neuritic tau accumulation in AD. The total of neuritic α-synuclein and tau accumulation is proportionate to the degree of Aβ deposits regardless of the cases is DLB or AD. Aβ may promote accumulation of not only tau but also α-synuclein. We speculate that, if the process is shifted toward tau accumulation, the manifestation becomes AD, and, if it is shifted toward α-synuclein accumulation, the manifestation becomes DLB

Report

(5 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (66 results)

All 2006 2005 2004 2003 Other

All Journal Article (58 results) Book (2 results) Publications (6 results)

  • [Journal Article] 病理学からみた認知症におけるニコチン性アセチルコリン受容体の意義とその機能2006

    • Author(s)
      秋山治彦
    • Journal Title

      Cognition and Dementia 5 : 7-12 5

      Pages: 7-12

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 認知症の予防と治療,そのエビデンス 5.内科疾患からみた認知症の予防 3)神経炎症の立場から(NSAIDsなども含め)2006

    • Author(s)
      秋山治彦
    • Journal Title

      Progress in Medicine 26

      Pages: 415-419

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] アミロイドβタンパク質(Aβ),タウ,αシヌクレインとグリア2006

    • Author(s)
      秋山治彦
    • Journal Title

      神経精神薬理学雑誌 26

      Pages: 23-31

    • NAID

      10017327997

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] 病理学からみた認知症におけるニコチン性アセチルコリン受容体の意義とその機能2006

    • Author(s)
      秋山治彦
    • Journal Title

      Cognition and Dementia 5

      Pages: 7-12

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Argyrophilic grains are not always argyrophilic-Distinction from neurofibrillary tangles of diffuse neurofibrillary tangles with calcification revealed by comparison between Gallyas and Campbell-Switzer methods2005

    • Author(s)
      Uchihara T, et al.
    • Journal Title

      Acta Neuropathol 110

      Pages: 158-164

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Distribution of cerebral cortical lesions in diffuse neurofibrillary tangles with calcification : a clinicopathological study of four autopsy cases showing prominent parietal lobe involvement2005

    • Author(s)
      Tsuchiya K, et al.
    • Journal Title

      Acta Neuropathol 110

      Pages: 57-68

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Silver staining profiles distinguish Pick bodies from neurofibrillary tangles of Alzheimer type : comparison between Gallvas and CamDbell-Switzer methods2005

    • Author(s)
      Uchihara T, et al.
    • Journal Title

      Acta Neuropathol 109

      Pages: 483-489

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Constant and severe involvement of Betz cells in corticobasal degeneration is not consistent with pyramidal signs a clinicopathological study of ten autopsy cases2005

    • Author(s)
      Tsuchiya K, et al.
    • Journal Title

      Acta Neuropathol 109

      Pages: 353-366

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] "Forme fruste"of amyoptrophic lateral sclerosis with dementia : A report of five autopsy cases without dementia and with ubiauitinated intraneuronal inclusions2005

    • Author(s)
      Ota S, et al.
    • Journal Title

      Neuropathology 25

      Pages: 326-335

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Degeneration of the inferior olive in spinocerellar ataxia 6 may depend on disease duration : Report of two autopsy cases and statistical analysis of autopsy cases reported to date2005

    • Author(s)
      Tsuchiya K, et al.
    • Journal Title

      Neuropathology 25

      Pages: 125-135

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Semantic dementiaを呈したDementia lacking distinctive histologyの1剖検例2005

    • Author(s)
      太田聡, 他
    • Journal Title

      脳と神経 57

      Pages: 233-238

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] 多数のargyrophilic grainを伴ったDementia with Lewybodiesの1剖検例2005

    • Author(s)
      大島健一, 他
    • Journal Title

      脳と神経 57

      Pages: 695-700

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] アルツハイマー病とミクログリア2005

    • Author(s)
      秋山治彦
    • Journal Title

      神経研究の進歩 49

      Pages: 347-356

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] 抗炎症薬による治療アプローチの現状と課題2005

    • Author(s)
      秋山治彦
    • Journal Title

      老年精神医学 16(増刊III)

      Pages: 135-140

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] アルツハイマー病の治療 : NMDA受容体拮抗薬,NSAIDs等2005

    • Author(s)
      秋山治彦
    • Journal Title

      モダンフィジシャン 25

      Pages: 1092-1095

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Early diagnosis of Alzheimer's type dementia with special reference to the clinicopahology of mild cognitive impairment2005

    • Author(s)
      Ikeda K, et al.
    • Journal Title

      Psychogeriatrics 4

      Pages: 89-95

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Argyrophilic grains are not always argyrophilic-Distinction from neurofibrillary tangles of diffuse neurofibrillary tangles with calcification revealed by comparison between Gallyas and Campbell-Switzer methods.2005

    • Author(s)
      Uchihara T, et al.
    • Journal Title

      Acta Neuropathol 110

      Pages: 158-164

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Distribution of cerebral cortical lesions in diffuse neurofibrillary tangles with calcification : a clinicopathological study of four autopsy cases showing prominent parietal lobe involvement.2005

    • Author(s)
      Tsuchiya K, et al.
    • Journal Title

      Acta Neuropathol 110

      Pages: 57-68

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Silver staining profiles distinguish Pick bodies from neurofibrillary tangles of Alzheimer type : comparison between Gallyas and Campbell-Switzer methods.2005

    • Author(s)
      Uchihara T, et al.
    • Journal Title

      Acta Neuropathol 109

      Pages: 483-489

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Constant and severe involvement of Betz cells in corticobasal degeneration is not consistent with pyramidal signs : a clinicopathological study of ten autopsy cases.2005

    • Author(s)
      Tsuchiya K, et al.
    • Journal Title

      Acta Neuropathol 109

      Pages: 353-366

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] "Forme fruste" of amyoptrophic lateral sclerosis with dementia : A report of five autopsy cases without dementia and with ubiquitinated intraneuronal inclusions.2005

    • Author(s)
      Ota S, et al.
    • Journal Title

      Neuropathology 25

      Pages: 326-335

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Degeneration of the inferior olive in spinocerellar ataxia 6 may depend on disease duration : Report of two autopsy cases and statistical analysis of autopsy cases reported to date.2005

    • Author(s)
      Tsuchiya K, et al.
    • Journal Title

      Neuropathology 25

      Pages: 125-135

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Silver staining profiles distinguish Pick bodies from neurofibrillary tangles of Alzheimer type : comparison between Gallyas and Campbell-Switzer methods2005

    • Author(s)
      Uchihara T, et al.
    • Journal Title

      Acta Neuropathol 109

      Pages: 483-489

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Constant and severe involvement of Betz cells in corticobasal degeneration is not consistent with pyramidal signs : a clinicopathological study of ten autopsy cases2005

    • Author(s)
      Tsuchiya K, et al.
    • Journal Title

      Acta Neuropathol 109

      Pages: 353-366

    • Related Report
      2005 Annual Research Report
  • [Journal Article] アルツハイマー病の治療:NMDA受容体拮抗薬,NSAIDs等2005

    • Author(s)
      秋山治彦
    • Journal Title

      モダンフィジシャン 25

      Pages: 1092-1095

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Amino-truncated amyloid beta-peptide(Abeta5-40/42) produced from caspase-cleaved amyloid precursor protein is deposited in Alzheimer's disease brain.2004

    • Author(s)
      Takeda K, Araki W, Akiyama H, Tabira T
    • Journal Title

      FASEB J 18

      Pages: 1755-1757

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Activation of vascular endothelial cells and perivascular cells by systemic inflammation - an immunohistochemical study of postmortem human brain tissues -2004

    • Author(s)
      Uchikado H, Akiyama H, Kondo H, Ikeda K, Tsuchiya K, Kato M, Oda T, et al.
    • Journal Title

      Acta Neuropathol 107

      Pages: 341-351

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Specificity of mechanisms for plaque removal after Abeta immunotherapv for Alzheimer's disease.2004

    • Author(s)
      Akiyama H, McGeer PL
    • Journal Title

      Nat Med 10

      Pages: 117-118

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Immunohistochemical study of tau accumulation in early stages of Alzheimer-type neurofibrillary lesions.2004

    • Author(s)
      Togo T, Akiyama H, Iseki E, Uchikado H, Kondo H, Ikeda K, Tsuchiya K, et al.
    • Journal Title

      Acta Neuropathol 107

      Pages: 504-508

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Sporadic amyotrophic lateral sclerosis of long duration mimicking spinal progressive muscular atrophy exists : Additional autopsy case with a clinical course of 19 years.2004

    • Author(s)
      Tsuchiya K, Sano M, Shiotsu H, Akiyama H, Watabiki S, Taki K, Kondo H, et al.
    • Journal Title

      Neuropathology 24

      Pages: 228-235

    • NAID

      10014201787

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Expression of BRI, the normal precursor for the amyloid protein of familial British dementia, in human brain2004

    • Author(s)
      Akiyama H, Kondo H, Arai T, Ikeda K, Kato M, Iseki E, Scwab C, McGeer PL
    • Journal Title

      Acta Neuropathol 107

      Pages: 53-84

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification of amino-terminally cleaved tau fragments that distinguish progressive supranuclear palsy from corticobasal degeneration2004

    • Author(s)
      Arai T, Ikeda K, Akiyama H, Nonaka T, Hasegawa M, Ishiguro K, Iritani S
    • Journal Title

      Ann Neurol 55

      Pages: 71-79

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] ミクログリアとアミロイドβ蛋白質2004

    • Author(s)
      秋山治彦
    • Journal Title

      医学のあゆみ 209

      Pages: 905-906

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] ミクログリアの病理学的所見2004

    • Author(s)
      秋山治彦
    • Journal Title

      Cognition & Dementia 3

      Pages: 35-40

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] アルツハイマー病 : 抗炎症薬2004

    • Author(s)
      秋山治彦
    • Journal Title

      Brain Medical 16

      Pages: 16-20

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Motor neuron disease group accompanied by inclusions of unidentified protein signaled by ubiquitin.2004

    • Author(s)
      Ikeda K, Tsuchiya K
    • Journal Title

      Neuropathology 24

      Pages: 117-124

    • NAID

      10014201353

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Amino-truncated amyloid beta-peptide (Abeta5-40/42) produced from caspase-cleaved amyloid precursor protein is deposited in Alzheimer's disease brain.2004

    • Author(s)
      Takeda K, et al.
    • Journal Title

      FASEB J 18

      Pages: 1755-1757

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Activation of vascular endothelial cells and perivascular cells by systemic inflammation - an immunohistochemical study of postmortem human brain tissues -2004

    • Author(s)
      Uchikado H, et al.
    • Journal Title

      Acta Neuropathol 107

      Pages: 341-351

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Specificity of mechanisms for plaque removal after Abeta immunotherapy for Alzheimer's disease.2004

    • Author(s)
      Akiyama H, McGeer PL
    • Journal Title

      Nat Med 10

      Pages: 117-118

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Immunohistochemical study of tau accumulation in early stages of Alzheimer-type neurofibrillary lesions.2004

    • Author(s)
      Togo T, et al.
    • Journal Title

      Acta Neuropathol 107

      Pages: 504-508

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Sporadic amyotrophic lateral sclerosis of long duration mimicking spinal progressive muscular atrophy exists : Additional autopsy case with a clinical course of 19 years.2004

    • Author(s)
      Tsuchiya K, et al.
    • Journal Title

      Neuropathology 24

      Pages: 228-235

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Expression of BRI, the normal precursor forof the amyloid protein of familial British dementia, in human brain,2004

    • Author(s)
      Akiyama H, et al.
    • Journal Title

      Acta Neuropathol 107

      Pages: 53-84

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification of amino-terminally cleaved tau fragments that distinguish progressive supranuclear palsy from corticobasal degeneration,2004

    • Author(s)
      Arai T, et al.
    • Journal Title

      Ann Neurol 55

      Pages: 71-79

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Early diagnosis of Alzheimer's type dementia with special reference to the clinicopahology of mild cognitive impairment.2004

    • Author(s)
      Ikeda K, et al.
    • Journal Title

      Psychogeriatrics 4

      Pages: 89-95

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Expression of BRI, the normal precursor forof the amyloid protein of familial British dementia, in human brain2004

    • Author(s)
      Akiyama H, Kondo H, Arai T, Ikeda K, Kato M, Iseki E, Scwab C, McGeer PL
    • Journal Title

      Acta Neuropathol 107

      Pages: 53-84

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Identification of amino-terminally cleaved tau fragments that distinguish progressive supranuclear palsy from corticobasal degeneration2004

    • Author(s)
      Arai t, Ikeda K, Akiyama H, Nonaka T, Hasegawa M, Ishiguro K, Iritani S, et al.
    • Journal Title

      Ann Neurol 55

      Pages: 71-79

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Different immunoreactivities of the microtubule-binding region of tau and its molecular basis in brains from Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration,2003

    • Author(s)
      Arai T, et al.
    • Journal Title

      Acta Neuropathol 105

      Pages: 489-498

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Atypical late-onset dementia characterized by limbic degeneration with coiled bodies and argyrophilic threads2003

    • Author(s)
      Oshima K, et al.
    • Journal Title

      Clin Neuropathol 22

      Pages: 296-303

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 4-Repeat tauopathy sharing pathological and biochemical features of corticobasal degeneration and progressive supranuclear palsy2003

    • Author(s)
      Katuse O, et al.
    • Journal Title

      Acta Neuropathol 106

      Pages: 251-260

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p622003

    • Author(s)
      Arai T, et al.
    • Journal Title

      Neurosci Lett 342

      Pages: 41-44

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 抗炎症剤による治療の試みの現況2003

    • Author(s)
      秋山治彦
    • Journal Title

      老年精神医学雑誌 14

      Pages: 539-544

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] アルツハイマー病と免疫・炎症反応-Aβワクチン,抗炎症剤2003

    • Author(s)
      秋山治彦
    • Journal Title

      Dementia Japan 17

      Pages: 117-125

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 非アルツハイマー型変性痴呆の最近の分類と知見.2003

    • Author(s)
      池田研二
    • Journal Title

      老年精神医学雑誌 14

      Pages: 276-286

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 脳の老化・再考.脳の老化とグリア細胞の変化.2003

    • Author(s)
      池田研二
    • Journal Title

      老年精神医学雑誌 14

      Pages: 977-983

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Two distinct subgroups of senile dementia of Alzheimer type : quantitative study of neurofibrillary tangles.2003

    • Author(s)
      Mizuno Y, Ikeda K, Tsuchiya K, Ishihara R, Shibayama H
    • Journal Title

      Neuropathology 23

      Pages: 282-289

    • NAID

      50000364513

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Different immunoreactivities of the microtubule-binding region of tau and its molecular basis in brains from Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration2003

    • Author(s)
      Arai T, et al.
    • Journal Title

      Acta Neuropathol 105

      Pages: 489-498

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Atypical late-onset dementia characterized by limbic degeneration with coiled bodies and argyrophilic threads.2003

    • Author(s)
      Oshima K, et al.
    • Journal Title

      Clin Neuropathol 22

      Pages: 296-303

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 4-Repeat tauopathy sharing pathological and biochemical features of corticobasal degeneration and progressive supranuclear palsy,2003

    • Author(s)
      Katsuse O, et al.
    • Journal Title

      Acta Neuropathol 106

      Pages: 251-260

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Progress in Alzheimer's and Parkinson's; Diseases (Edited by I. Hanim, R. Cacabelos & A. Fisher)2005

    • Author(s)
      Akiyama H, et al.
    • Publisher
      Taylor & Francis, London
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Progress in Alzheimer's and Parkinson's ; Diseases(Edited by I.Hanim, R.Cacabelos & A.Fisher)2005

    • Author(s)
      Akiyama H, et al.
    • Publisher
      Taylor & Francis, London
    • Related Report
      2005 Annual Research Report
  • [Publications] 池田研二: "非アルツハイマー型変性痴呆の最近の分類と知見"老年精神医学雑誌. 14. 276-286 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 池田研二: "脳の老化・再考.脳の老化とグリア細胞の変化"老年精神医学雑誌. 14. 977-983 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Mizuno Y, Ikeda K, Tsuchiya K, Ishihara R, Shibayama H: "Two distinct subgroups of senile dementia of Alzheimer type : quantitative study of neurofibrillary tangles."Neuropathology. 23. 282-289 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ikeda K, Tsuchiya K: "Motor neuron disease group accompanied by inclusions of unidentified protein. signaled by ubiquitin."Neuropathology. 24. 117-124 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ikeda K et al.: "Morphometrical reappraisal of motor neuron system of Pick's disease and amyotrophic lateral sclerosis with dementia"Acta Neuropathol. 104. 21-28 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 池田研二: "痴呆性疾患の病理"クリニカ. 29. 177-182 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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