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Inleetin and pathogenetic role of lymphotropic viruses in hematological malignancies.

Research Project

Project/Area Number 14570986
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionKochi University

Principal Investigator

DAIBATA Masanori  Kochi University, Faculty of Medicine, Assistant Professor, 医学部附属病院, 講師 (50263976)

Co-Investigator(Kenkyū-buntansha) TAGUCHI Takahiro  Kochi University, Graduate School of Kuroshio Science, Instructor, 黒潮圏海洋科学研究科, 助手 (80127943)
Project Period (FY) 2002 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2004: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2003: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2002: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsHematological malignancies / Epstein-Barr virus / human herpesvirus 6 / human herpesvirus 8 / virus-associated diseases / 悪性リンパ腫 / Simian virus 40 / 造血器腫瘍 / ヒトヘルペスウイルス6 / 膿胸関連リンパ腫 / 染色体
Research Abstract

1.Epstein-Barr virus(EBV) is associated with several lymphoproliferative diseases. Pyothorax-associated lymphoma(PAL) is closely associated with EBV, but how this virus contributes to the development of the lymphoma is known. PAL would provide an excellent model for investigation of virus-associated lymphomagenesis, and establishment of PAL-derived cell lines is desirable. In this study, we have successfully established a novel PAL cell line. The cell line unexpectedly possessed integrated EBV at a specific site. The viral integration event is suggested to enhance a chromosomal instability at the insertion site. The cell line represents the first example of EBV integration in PAL and could enable the study of the role of integrated viral infection in lymphomagenesis.
2.EBV and other diseases : (1)It is known that monoclonal EBV infection is observed in 10-15% of gastiric carcinoma. We described for the first time a case of concomitant gastric lymphoma and adult T-cell leukemia/lymphoma in which EBV infected cells were detected. (2)We also proposed that reactivated EBV infection is associated with a subset of pure red cell aplasia.
3 Human herpesvirus 6 (HHV-6) and diseases : The etiology and adult onset Still's disease is known. We suggested that reactivated HHV-6 infection could be a causative factor of adult onset Still's disease.
4.HHV-8 and diseases : The causative relation between HHV-8 and primary pulmonary hypertension (PPH) has been suggested in USA patients. However, our study showed no association of HHV-8 with PPH in Japanese patients.
5 Other virus : Two USA groups reported that simian virus 40 (SV40) was detected in about 40% of lymphoma. In this study, we looked for SV40 in samples from Japanese patients with lymphoproliferative disorders. The virus was detected in only 3 (1.7%) of 178 samples, suggesting that SV40 is unlikely to play a pathogenetic role in Japanese patients.

Report

(4 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (43 results)

All 2005 2004 2003 2002 Other

All Journal Article (33 results) Publications (10 results)

  • [Journal Article] Alterations of DNA damage-response genes ATM and ATR in pyothorax-associated lymphoma.2005

    • Author(s)
      Angen Liu, et al.
    • Journal Title

      Lab.Invest. 85

      Pages: 436-446

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Induction of lytic Epstein-Barr virus (EBV) infection by synergistic action of rituximab and dexamethasone renders EBV-positive lymphoma cells more susceptible to ganciclovir cytotoxicity in vitro and in vivo.2005

    • Author(s)
      Masanori Daibata, et al.
    • Journal Title

      J.Virol. 79

      Pages: 5875-5879

    • NAID

      120001718176

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Viral pneumonia : Coinfection of Cytomegarovirus and herpes simplex virus.2005

    • Author(s)
      Isao Miyoshi, et al.
    • Journal Title

      Int.Med. (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Alterations of DNA damage-response genes ATM and ATR in pyothorax-associated lymphoma.2005

    • Author(s)
      Angen Liu
    • Journal Title

      Lab.Invest. 85

      Pages: 436-446

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Induction of lytic Epstein-Barr virus (EBV) infection by synergistic action of rituximab and dexamethasone renders EBV-positive lymphoma cells more susceptible to ganciclovir cytotoxicity in vitro and in vivo.2005

    • Author(s)
      Masanori Daibata
    • Journal Title

      J.Virol. 79

      Pages: 5875-5879

    • NAID

      120001718176

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Viral pneumonia : Coinfection of Cytomegarovirus and herpes simplex virus.2005

    • Author(s)
      Isao Miyoshi
    • Journal Title

      Int.Med. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Alterations of DNA damage-response genes ATM and ATR in pyothorax-associated lymphoma.2005

    • Author(s)
      T.Liu, et al.
    • Journal Title

      Lab.Invest. 85

      Pages: 436-446

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Differential gene-expression profiling in the leukemia cell lines derived from indolent and aggressive phases of CD56^+ T-cell large granular lymphocyte leukemia.2004

    • Author(s)
      Masanori Daibata, et al.
    • Journal Title

      Int.J.Cancer. 108

      Pages: 845-851

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Absence of human herpesvirus 8 in lung tissues from Japanese patients with primary pulmonary hypertension.2004

    • Author(s)
      Masanori Daibata, et al.
    • Journal Title

      Res.Med. 98

      Pages: 1231-1232

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Lymphoma associated with Epstein-Barr virus-positive pyothorax.2004

    • Author(s)
      Masanori Daibata, et al.
    • Journal Title

      Int.Med. 43

      Pages: 1210-1211

    • NAID

      10014210254

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Differential gene-expression profiling in the leukemia cell lines derived from indolent and aggressive phases of CD56^+ T-cell large granular lymphocyte leukemia.2004

    • Author(s)
      Masanori Daibata
    • Journal Title

      Int.J.Cancer. 108

      Pages: 845-851

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Absence of human herpesvirus 8 in lung tissues from Japanese patients with primary pulmonary hypertension.2004

    • Author(s)
      Masanori Daibata
    • Journal Title

      Res.Med. 98

      Pages: 1231-1232

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Lymphoma associated with Epstein-Barr virus-positive pyothorax.2004

    • Author(s)
      Masanori Daibata
    • Journal Title

      Int.Med. 43

      Pages: 1210-1211

    • NAID

      10014210254

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Absence of human herpesvirus 8 in lung tissues from Japanese patients with primary puimonary hypertension.2004

    • Author(s)
      M.Daibata, et al.
    • Journal Title

      Res.Med. 98

      Pages: 1231-1232

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Lymphoma associated with Epstein-Barr virus-positive pyothorax.2004

    • Author(s)
      M.Daibata, et al.
    • Journal Title

      Int.Med. 43

      Pages: 1210-1211

    • NAID

      10014210254

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Non-multiple lymphomatous polyposis form of mantle cell lymphoma in the gastrointestinal tract.2004

    • Author(s)
      S.Tamura, et al.
    • Journal Title

      J.Gastroenterol. 39

      Pages: 995-1000

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 悪性リンパ腫のすべて・リンパ腫の発病機序:HHV-6.2004

    • Author(s)
      大畑雅典
    • Journal Title

      血液・腫瘍科 49・4

      Pages: 94-97

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Simian virus 40 in Japanese patients with lymphoproliferative disorders.2003

    • Author(s)
      Masanoti Daibata, et al.
    • Journal Title

      Br.J.Haematol. 121

      Pages: 190-191

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Epstein-Barr virus in concomitant gastric carcinoma and adult T-cell leukemia/lymphoma.2003

    • Author(s)
      Masanori Daibata, et al.
    • Journal Title

      Am.J.Med. 114

      Pages: 509-510

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Pure red cell aplasia in a patient with trisomy X chromosome abnormality and reactivated Epstein-Barr virus infection.Int.2003

    • Author(s)
      Masanori Daibata, et al.
    • Journal Title

      Int.J.Hematol. 77

      Pages: 354-358

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Simian virus 40 in Japanese patients with lymphoproliferative disorders.2003

    • Author(s)
      Masanori Daibata
    • Journal Title

      Br.J.Haematol. 121

      Pages: 190-191

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Epstein-Barr virus in concomitant gastric carcinoma and adult T-cell leukemia/lymphoma.2003

    • Author(s)
      Masanori Daibata
    • Journal Title

      Am.J.Med. 114

      Pages: 509-510

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Pure red cell aplasia in a patient with trisomy X chromosome abnormality and reactivated Epstein-Barr virus infection2003

    • Author(s)
      Masanori Daibata
    • Journal Title

      Int.J.Hematol. 77

      Pages: 354-358

    • NAID

      50000835827

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Epstein-Barr virus (EBV)-positive pyothorax-associated lymphoma (PAL) : chromosomal integration of EBV in a novel CD2-positive PAL B-cell line.2002

    • Author(s)
      Masanori Daibata, et al.
    • Journal Title

      117

      Pages: 546-557

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A novel chromosome translocation (16;20)(q22;p13) in polycythemia vera.2002

    • Author(s)
      Masanori Daibata, et al.
    • Journal Title

      Cancer Genet.Cytogenet. 137

      Pages: 29-32

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Human herpesvirus 6 in progressive multifocal leukoencephalopathy.2002

    • Author(s)
      Masanori Daibata, et al.
    • Journal Title

      Infectious Diseases Review. 2

      Pages: 10-11

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Human herpesvirus 6 and adult-onset Still's disease.2002

    • Author(s)
      Masanori Daibata, et al.
    • Journal Title

      Am.J.Med. 113

      Pages: 532-532

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Malignant lymphoma with human herpesvirus 6-positive multifocal leukoencephalopathy.2002

    • Author(s)
      Masanori Daibata, et al.
    • Journal Title

      Review Series : Oncology. 1

      Pages: 11-13

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Epstein-Barr virus (EBV)-positive pyothorax-associated lymphoma (PAL) : chromosomal integration of EBV in a novel CD2-positive PAL B-cell line.2002

    • Author(s)
      Masanori Daibata
    • Journal Title

      117

      Pages: 546-557

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A novel chromosome translocation (16;20)(q22;p13) in polycythemia vera.2002

    • Author(s)
      Masanori Daibata
    • Journal Title

      Cytogenet. 137

      Pages: 29-32

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Human herpesvirus 6 in progressive multifocal leukoencephalopathy.2002

    • Author(s)
      Masanori Daibata
    • Journal Title

      Infectious Diseases Review 2

      Pages: 10-11

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Human herpesvirus 6 and adult-onset Still's disease.2002

    • Author(s)
      Masanori Daibata
    • Journal Title

      Am.J.Med. 113

      Pages: 532-532

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Malignant lymphoma with human herpesvirus 6-positive multifocal leukoencephalopathy.2002

    • Author(s)
      Masanori Daibata
    • Journal Title

      Review Series : Oncology 1

      Pages: 11-13

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] M.Daibata, et al.: "Simian virus 40 in Japanese patients with lymphoproliferative disorders"Bri.J.Haematol.. 121. 190-191 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] M.Daibata, et al.: "Epstein-Barr virus in concomitant gastric carcinoma and adult T-cell leukemia/lymphoma"Am.J.Med.. 114. 509-510 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] M.Daibata, et al.: "Pure red cell aplasia in a patient with trisomy X chromosome abnormality and reactivated Epstein-Barr virus infection"Int.J.Hematol.. 77. 354-358 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] M.Daibata, et al.: "Differential gene-expression profiling in the leukemia cell lines derived from indolent and aggressive phase of CD56' T-cell large granular lymphocyte leukemia"Int.J.Cancer. 108. 845-851 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] M.Daibata, et al.: "Epstein-Barr virus (EBV)-positive pyothorax-associafed lymphoma (PAL) : chromosomal integration of EBV in a novel CD2-positive PAL B-cell line"Br. J. Haematol.. 117. 546-557 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] M.Daibata, et al.: "Human herpesvirus 6 and adult-onset Still's disease"Am. J. Med.. 113. 532 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] M.Daibata, et al.: "Malignant lymphoma with human herpesvirus 6-positive multifocal lenkoencephalopathy"Review Series : Oncology. 1. 11-13 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] M.Daibata, et al.: "A novel chromosome translocation ( 16;20)(q22;p13) in polycythemia vera"Cancer Genel. Cytogenet.. 137. 29-32 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] M.Daibata, et al.: "Human herpesvirus 6 in progressive multifocal leukoencephalopathy"Review Series : Infectious Diseases. 2. 10-11 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 大畑 雅典: "ウイルスと悪性リンパ腫"現代医療. 34. 63-68 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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