| Project/Area Number |
14571004
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
MORI Shinichiro Kansai Medical University, Faculty of Medicine, Assistant professor, 医学部, 講師 (60330205)
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| Co-Investigator(Kenkyū-buntansha) |
AMAKAWA Ryuichi Kansai Medical University, Faculty of Medicine, Associated professor, 医学部, 助教授 (10309213)
FUKUHARA Shirou Kansai Medical University, Faculty of Medicine, Professor, 医学部, 教授 (40142301)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2003: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2002: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Dendritic cell / Gastric MALT lymphoma / Th polarization / Chronic gastritis / MALTリンパ腫 / 低悪性度MALTリンパ腫 / T細胞 |
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| Research Abstract |
We studied 8 cases of chronic gastritis and 6 cases of gastric MALT lymphoma to evaluate the distribution of dendritic cell(DC) by immunohistochemical analysis with DC specific monoclonal antibody ; fascin. We observed fascin-positive DC in chronic gastritis and gastric MALT lymphoma. All cases of gastric MALT lymphoma showed presence of fascin-positive DC. However, 5 cases of chronic gastritis showed no involvement of fascin-positive DC. DC were mainly presented within T cell infiltrating interfollicular zone in gastric MALT lymphoma. Fascin-positive DC were expressed CD1a-,CD4-,CD21-,DC-LAMP+,IL-3R-. These finding suggested DC in gastric MALT lymphoma were mainly myeloid lineage DC. Cytokines producing by DC is key role in Th balance. Therefore, we performed immunohistochemical analysis of cytokines expression in MALT lymphoma. In 3 cases of gastric MALT lymphoma we observed no expression of IL-12,IFN-α, and IL-4. We detected only IFN-y expression in all cases. These findings suggested that gastric MALT lymphoma might be Th1 disease.
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