| Co-Investigator(Kenkyū-buntansha) |
MINAMI Naoyoshi Tohoku University, Hospital, Research Associate, 医学部附属病院, 助手 (80333821)
KANAZAWA Masayuki Tohoku University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 (60282050)
KOHZUKI Masahiro Tohoku University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (70234698)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2002: ¥2,700,000 (Direct Cost: ¥2,700,000)
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| Research Abstract |
We assessed the renal effects of chronic exercise (EX) in a rat with CRF. Rats were randomly divided into 4 groups:1)no EX (C);2)moderate EX (mEX);3)intense EX (iEX);4)mEX+enalapril(ENA), for 12 weeks. The systolic blood pressure(SBP), the urinary excretion of protein(UP), serum creatinine(Scr), blood urea nitrogen(BUN), the index of glomerular sclerosis(IGS) in the iEX and mEX+ENA groups were significantly lower than those of the C group. The SBP, Scr, BUN, IGS in the mEX group were significantly lower than those of the C group. The JGS in the mEX+ENA group was significantly lower than that of all other groups. These results indicate that moderate to intense EX has renoprotective effects and indicate that antihypertensive therapy with an angiotensin enzyme inhibitor has additional renal protective effects.
We determined whether single or combined therapy could influence the glucose and lipid metabolism parameters as well as PPAR_expression in fat and skeletal muscle tissues an animal model of insulin-resistant, hypertensive rats. Spontaneously hypertensive rats (SHRs) were fed a fructose-rich diet over 16 weeks of either exercise training (Ex, 20m/min, 0%grade, 60min/day, 5 days/wk), ACE inhibitor (TM, temocapril, 10mg/kg/day) administration, or a combination of exercise training and ACE inhibitor administration. (TM+Ex). The results suggested that PPARγ expression is tissue specific and may be influenced by diet, endurance training, and ACE inhibition, or combinations, there of Altered PPARγ protein expression by the two interventions may partly explain their insulin-sensitizing capabilities.
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