| Project/Area Number |
14571061
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Gifu University |
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Principal Investigator |
YAMAMOTO Mayumi (2003) Gifu University Hosp., 3rd Dept. of Int. Med., Lectureler, 医学部附属病院, 講師 (40313879)
安田 圭吾 (2002) 岐阜大学, 医学部, 教授 (10004714)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIZAWA Masayoshi Gifu University Hosp., 3rd Dept. of Int. Med., Lectureler, 医学部附属病院, 講師 (20313893)
武田 則之 岐阜大学, 医学部, 助教授 (20163412)
山本 眞由美 岐阜大学, 医学部, 助手 (40313879)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2003: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2002: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | DHEA / insulin / insulin resisitance / PPAR / fat / breast cancer / obesity / PPAR-【○!C】 / 動脈硬化 / PPARγ / アンドロゲン |
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| Research Abstract |
We investigated effects of DHEA(S) on the progression of life style-related diseases.
DHEA and insulin resistance : DHEA activated P13-kinase and atypical PKC in rat adipocytes. Since these activation induced glucose uptake, DHEA may improve insurin resistance in the insulin target organs.
DHEA and obesity : DHEA decreased the expression levels of PPAR and triglyceride volume through the suppression of mRNA levels in adipocyte lipid-binding protein and sterol regulatory element-binding protein. DHEA might have an important roles in function of adipocytes.
DHEA and breast cancer : DHEA increased the human breast cancer cell proliferation as a mitogen, which was diminished with 4-hydroxyandrostendione inhibiting aromatase enzyme.
DHEA administration might have an advantage to prevent some of life style-related diseases like obesity and diabetes mellitus.
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