• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Identification of RXR antagonists and characterization of potent stimulation of ST 13 preadipocyte differentiation

Research Project

Project/Area Number 14571118
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionTokyo Metropolitan Organization for Medical Research

Principal Investigator

SATO Mayumi  TOKYO METROPOLITAN ORGANIZATION FOR MEDICAL RESEARCH, THE TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE, RESEARCHER, 東京都臨床医学総合研究所, 主任研究員 (50124459)

Co-Investigator(Kenkyū-buntansha) YAJIMA Yukiko  TOKYO MEDICAL AND DENTAL UNIVERCITY, SCHOLL OF BIOMEDICAL SCIENCE, PROFFECER (60090114)
KAHECHIKAK Hiroyuki  TOKYO MEDICAL AND DENTAL UNIVERCITY, SCHOLL OF BIOMEDICAL SCIENCE, PROFFECER, 教授 (20177348)
Project Period (FY) 2002 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2004: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2003: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2002: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsdiabetes / nuclear receptor / RXR / adipocyte / PPAR / RXR antagonist / PPARγ / 生活習慣病 / アンタゴニスト
Research Abstract

Retinoid X receptor (RXR) ligands PA451 and PA452 are RXR pan-antagonist and HX531 is RXR pan-antagonist with retinoic acid receptor (RAR) pan-antagonist. Ligand displacement assay elucidate that these RXR antagonist displaced natural ligand 9-cis-retinoic acid from recombinant RXR strongly. Two-hybrid assay in mammalian cells demonstrated that RXR antagonists inhibited ligand dependent RXR binding to coactivator SRC-1 (steroid receptor coactivator) dose dependently. These results indicate the compounds are full competitive antagonists of RXR, and the ideal antagonists are not produced until now. Although these RXR antagonists function as antagonist toward RXR : RAR heterodimer, as agonist toward RXR : PPARγ (peroxisome proliferator activated receptor). This agonism of RXR antagonists also demonstrates against endogenous RXR : PPARγ. Simultaneous treatment with RXR antagonists and PPARγ agonist enhance the transactivation of PPARγ response element (PPRE) via RXR : PPARγ and induction of ST 13 preadipocyte differentiation. A chimera PPARγ receptor (PPARγ-RARγ) was constructed which ligand-binding domain of PPARγ has been replacing RARγ. The agonistic action of these RXR antagonists on RXR : PPAR exchange to antagonistic action on RXR : PPAR-RAR chimera receptor. These results suggest that amphypathic activity appeared in these RXR antagonists is depend on the structure of ligand binding domain of heterodimer partner. This is the first report of RXR antagonist-mediated agonism of PPARγ activity.

Report

(4 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (59 results)

All 2005 2004 2003 2002 Other

All Journal Article (44 results) Book (3 results) Publications (12 results)

  • [Journal Article] Roles of cxc chemo-kines and macrophages in the recruitment of inflammatroy cells and tumor rejection induced by fas/apo-1 ligand-expressing tumor.2005

    • Author(s)
      Shimizu, M., Yoshimoto, T., Sato, M., et al.
    • Journal Title

      Int. J. Cancer 114

      Pages: 926-935

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Roles of cxc chemo-kines and macrophages in the recruitment of inflammatroy cells and tumor rejection induced by fas/apo-1 ligand-expressing tumor.2005

    • Author(s)
      Shimizu, M., Yoshimoto, T., Sato, M., et al.
    • Journal Title

      Int.J.Cancer 114

      Pages: 926-935

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Peroxisome proliferator activator receptors and angiogenesis.2005

    • Author(s)
      MAYUMI SATO
    • Journal Title

      NIPPON RINSHO 63

      Pages: 603-608

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] PPARs as Molecular targets for drug discovery.2005

    • Author(s)
      KAGECHIKA H., Miyachi H.
    • Journal Title

      NIPPON RINSHO 63

      Pages: 549-555

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Roles of calpain in the differentiation and function of adipocytes2004

    • Author(s)
      Yajima Y, Sato M, Kawashima S
    • Journal Title

      12^th International Congress of Endocrinology

      Pages: 547-551

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Nobel RXR antagonists enhance transactivaqtion of PPARγ and ST 13 Preadipocyte differentiation.2004

    • Author(s)
      Sato M., A.Sugawara, N.Egawa, Y.Yajima, H.Kato, H.Kagechika
    • Journal Title

      Internatinal Congress of Endocrinology

      Pages: 547-551

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Directed biosynthesis of fluorinated pseurotin A, Synerazol and Gliotoxin2004

    • Author(s)
      Igarashi.Y, Yabuta.Y, Sekine.A, et al.
    • Journal Title

      The J. of Antibiotics 57

      Pages: 784-754

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Design and synthesis of cyclic urea compounds : a pharmacological study for retinoidal activity2004

    • Author(s)
      Kurihara M, Rouf AS, Kansui H, Kagechika H, Okuda H, Miyata N.
    • Journal Title

      Bioorg Med Chem Lett 14

      Pages: 4131-4134

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Roles of calpain in the differentiation and function of adipocytes2004

    • Author(s)
      Yajima Y, Sato M, Kawashima S
    • Journal Title

      12^<th> Internatinal Congress of Endocrinology

      Pages: 949-952

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Nobel RXR antagonists enhance transactivaqtion of PPARγ and ST 13 preadipocyte differentiation.2004

    • Author(s)
      Sato M., A.Sugawara, N.Egawa, Y.Yajima, H.Kato, H.Kagechika
    • Journal Title

      12^<th> Internatinal Congress of Endocrinology

      Pages: 547-551

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Directed biosynthesis of fluorinated pseurotin A2004

    • Author(s)
      Igarashi.Y, Yabuta.Y, Sekine.A, et al.
    • Journal Title

      Synerazol and Gliotoxin The J.of Antibiotics 57

      Pages: 784-754

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Design and synthesis of cyclic urea compounds : a pharmacological study for retinoidal activity.2004

    • Author(s)
      Kurihara M, Rouf AS, Kansui H, Kagechika H, Okuda H, Miyata N.
    • Journal Title

      Bioorg Med Chem Lett. 14(16)

      Pages: 4131-4134

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Competitive RXR antagonists enhance transactivation of PPARγ and ST 13 preadipocyte differentiation 12^<th> International Congress of Endcrinology.2004

    • Author(s)
      MAYUMI SATO, AKIRA SUGAWARA, NAOTO EGAWA, YUKIKO YAJIMA, HIROYUKI KAGECHIKA.
    • Journal Title

      Portugal

      Pages: 831-904

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Directed biosynthesis of fluorinated pseurotin A, Synerazol and Gliotoxin2004

    • Author(s)
      Yasuhiro et al.
    • Journal Title

      The J.of Antibiotics 57

      Pages: 784-754

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Peroxisome proliferator activator receptor ligands and angiogenesis2004

    • Author(s)
      Mayumi Sato
    • Journal Title

      Nippon Rinsho 63

      Pages: 603-608

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Novel retinoid X receptor (RXR) antagonists having a dicarba-closo-dodecaboane as a hydrophobic moiety.2004

    • Author(s)
      Ohta K, Iijima T, Kawachi E, Kagechika H, Endo Y.
    • Journal Title

      Bioorg Med Chem Lett 14

      Pages: 5913-5918

    • Related Report
      2004 Annual Research Report
  • [Journal Article] ranscription Suppression of Thromboxane Receptor Gene Expression by Retinoids in Vascular Smooth Muscle Cells.2003

    • Author(s)
      Uruno A., Sugawara A., Kudo M., Sato M., et al.
    • Journal Title

      Hypertension Research 26

      Pages: 815-821

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Mechanism of adult primitive mesenchymal ST-13 preadipocyte differ entiation2003

    • Author(s)
      Yukiko Yajima, Mayumi Sato, Michihiro Sumida et al.
    • Journal Title

      Endocrinology 144

      Pages: 2559-2565

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of rhizoxin, a microbial angiogenesis inhibitor, on angiogenic endothelial cell functions2003

    • Author(s)
      Aoki, K., Watanabe, K., Sato M., et al.
    • Journal Title

      Eur. J. Pharmacol 459

      Pages: 131-138

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Utility of boron clusters for drug design. Relation between estrogen receptor binding affinity and hydrophobicity of phenols bearing various types of carboranyl groups.2003

    • Author(s)
      Endo Y, Yamamoto K, Kagechika H.
    • Journal Title

      Bioorg Med Chem Lett 13

      Pages: 4089-4092

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cyclooxygenase inhibitors derived from thalidomide.2003

    • Author(s)
      Suizu M, Muroya Y, Kakuta H, Kagechika H, Tanatani A, Nagasawa K, Hashimoto Y
    • Journal Title

      Chem Pharm Bull 9

      Pages: 1098-102

    • NAID

      110003615465

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Amide conformational switching induced by protonation of aromatic substituent..2003

    • Author(s)
      Yamasaki R, Tanatani A, Azumaya I, Saito S, Yamaguchi K, Kagechika H.
    • Journal Title

      Org Lett 5

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of retinoid ligands on RIP140 : molecular interaction with retinoid receptors and biological activity.2003

    • Author(s)
      Farooqui M, Franco PJ, Thompson J, Kagechika H, et al.
    • Journal Title

      Biochemistry 42

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Clinically potential subclasses of retinoid synergists revealed by gene expression profiling2003

    • Author(s)
      Ishida S, Shigemoto-Mogami Y, Kagechika H. et al.
    • Journal Title

      Mol Cancer Ther. 1

      Pages: 49-58

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of synthetic retinoid, TAC-101, on experimental autoimmune disease.2003

    • Author(s)
      Miyagawa N, Homma T, Kagechika et al.
    • Journal Title

      Pharmacology. 7

      Pages: 21-31

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Transcription Suppression of Thromboxane Receptor Gene Expression by Retinoids in Vascular Smooth Muscle Cells.2003

    • Author(s)
      Uruno A., Sugawara A., Kudo M., Sato M., Sato K., Ito S., Takeuchi K.
    • Journal Title

      Hypertension Research 26

      Pages: 815-821

    • NAID

      10012457647

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Mechanism of adult primitive mesenchymal ST-13 preadipocyte differentiation2003

    • Author(s)
      Yukiko Yajima, Mayumi Sato, Michihiro Sumida, Seiichi Kawashima.
    • Journal Title

      Endocrinology 144

      Pages: 2559-2565

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of rhizoxin, a microbial angiogenesis inhibitor, on angiogenic endothelial cell functions.2003

    • Author(s)
      Aoki, K., Watanabe, K., Sato M., et al.
    • Journal Title

      Eur.J.Pharmacol. 459(2-3)

      Pages: 131-138

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Utility of boron clusters for drug design. Relation between estrogen receptor binding affinity and hydrophobicity of phenols bearing various types of carboranyl groups.2003

    • Author(s)
      Endo Y, Yamamoto K, Kagechika H.
    • Journal Title

      Bioorg Med Chem Lett. 13(22)

      Pages: 4089-4092

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Cyclooxygenase inhibitors derived from thalidomide.2003

    • Author(s)
      Suizu M, Muroya Y, Kakuta H, Kagechika H, Tanatani A, Nagasawa K, Hashimoto Y.
    • Journal Title

      Chem Pharm Bull (Tokyo) 9

      Pages: 1098-1102

    • NAID

      110003615465

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Amide conformational switching induced by protonation of aromatic substituent.2003

    • Author(s)
      Yamasaki R, Tanatani A, Azumaya I, Saito S, Yamaguchi K, Kagechika H.
    • Journal Title

      Org Lett. 5(8)

      Pages: 1265-1267

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of retinoid ligands on RIP 140 : molecular interaction with retinoid receptors and biological activity.2003

    • Author(s)
      Farooqui M, Franco PJ, Thompson J, Kagechika H, Chandraratna RA, Banaszak L, Wei LN.
    • Journal Title

      Biochemistry 42(4)

      Pages: 971-979

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Clinically potential subclasses of retinoid synergists revealed by gene expression profiling.2003

    • Author(s)
      Ishida S, Shigemoto-Mogami Y, Kagechika H, Shudo K, Ozawa S, Sawada J, Ohno Y, Inoue K.
    • Journal Title

      Mol Cancer Ther. (1)

      Pages: 49-58

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of synthetic retinoid, TAC-101, on experimental autoimmune disease.2003

    • Author(s)
      Miyagawa N, Homma T, Kagechika H, Shudo K, Nagai H.
    • Journal Title

      Pharmacology 7(1)

      Pages: 21-31

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Nobel RXR antagonists enhance transactivaqtion of PPARγ and ST 13 preadipocyte differentiation2003

    • Author(s)
      M.Sato et al.
    • Journal Title

      12^<th> Internatinal Congress of Endocrinology

      Pages: 547-551

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Dehydrotrametenolic acid induces preadipocyte differentiation and sensitizes animal models of NonInsulin-dependent Diabetes Mellitus to insulin.2002

    • Author(s)
      Sato M., Takaaki Tai, Yoshiki N., Yukiko Yajima et al.
    • Journal Title

      Biological & Pharmaceutical Bulletin 25

      Pages: 81-86

    • NAID

      110003638671

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Novel retinoid X receptor antagonists : specific inhibition of retinoid synergism in RXR-RAR heterodimer actions2002

    • Author(s)
      Takahashi B, Ohta K, Kawachi E, Fukasawa H, Hashimoto Y, Kagechika H.
    • Journal Title

      J Med Chem. 45

      Pages: 3327-3330

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Novel synthetic retinoids and separation of the pleiotropic retinoidal activities2002

    • Author(s)
      Kagechika H.
    • Journal Title

      Curr Med Chem 5

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of natural and synthetic retinoids on the proliferation and differentiation of three canine melanoma cell lines2002

    • Author(s)
      Ohashi E, Inoue K, Kagechika H, et al.
    • Journal Title

      J Vet Med Sci 64

    • NAID

      130000449408

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Dehydrotrametenolic acid induces preadipocyte differentiation and sensitizes animal models of Nonlnsulin-dependent Diabetes Mellitus to insulin.2002

    • Author(s)
      Sato M., Takaaki Tai Yoshiki N.Yukiko Yajima, Seiichi Kawashima Keiji Tanaka
    • Journal Title

      Biological & Pharmaceutical Bulletin. 25(1)

      Pages: 81-86

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Novel retinoid X receptor antagonists : specific inhibition of retinoid synergism in RXR-RAR heterodimer actions.2002

    • Author(s)
      Takahashi B, Ohta K, Kawachi E, Fukasawa H, Hashimoto Y, Kagechika H.
    • Journal Title

      J Med Chem. 45(16)

      Pages: 3327-3330

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Novel synthetic retinoids and separation of the pleiotropic retinoidal activities.2002

    • Author(s)
      Kagechika H.
    • Journal Title

      Curr Med Chem. (5)

      Pages: 591-608

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effect of natural and synthetic retinoids on the proliferation and differentiation of three canine melanoma cell lines.2002

    • Author(s)
      Ohashi E, Inoue K, Kagechika H, et al.
    • Journal Title

      J Vet Med Sci. 64(2)

      Pages: 169-172

    • NAID

      130000449408

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Roles of cxc chemo-kines and macrophages in the recruitment of inflammatroy cells and tumor rejection induced by FAS /APO-1 (CD95) ligand-expressing tumor

    • Author(s)
      Shimizu, M., Yoshimoto, T., Sato, M., et al.
    • Journal Title

      Int.J.Cancer (in press)

    • Related Report
      2004 Annual Research Report
  • [Book] Peroxisome proliferator activator receptors and angiogenesis2005

    • Author(s)
      MAYUMI SATO
    • Total Pages
      6
    • Publisher
      日本臨床社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] PPARs as Molecular targets for drug discovery2005

    • Author(s)
      KAGECHIKA H., Miyachi H
    • Total Pages
      7
    • Publisher
      日本臨床社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] 脂肪細胞の分化とその機能におけるカルパインの役割2003

    • Author(s)
      矢島由紀子, 佐藤眞友美, 川島誠
    • Total Pages
      9
    • Publisher
      内分泌・糖尿病科
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Uruno, A., Sugawara, A., Kudo, M., Sato, M., Sato, K.: "Transcription Suppression of Thromboxane Receptor Gene Expression by Retinoids in Vascular Smooth Muscle Cells."Hypertension Research. 26. 815-821 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yajima, Y., Sato, M., Sumida, M., Kawashima, S.: "Mechanism of adult primitive mesenchymal ST-13 preadipocyte differentiation Endocrinology."Endocrinology. 144. 2559-2565 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Aoki, K, Watanabe, K., Sat M., Ikekita M, Hakamatsuka T, Oikawa, T.: "Effects of rhizoxin, a microbial angiogenesis inhibitor, on angiogenic endothelial cell functions."Eur J Pharmacol. 459. 131-138 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 矢嶋由紀子, 佐藤眞友美, 川島誠一: "脂肪細胞の分化とその機能におけるカルパインの役割"内分泌・糖尿病科. 16. 81-89 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Azumaya I, Kato T, Okamoto I, Yamasakie et al.: "Absolute helical arrangement of sulfonamide in the crystal."Org Lett.. 16. 3939-3942 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Endo Y, Yamamoto K, Kagechika H: "Utility of boron clusters for drug design. Relation between estrogen receptor binding affinity and hydrophobicity of phenols bearing various types of carboranyl groups."Bioorg Med Chem Lett.. 17. 4089-4092 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sato, M., Tai, T., Nunoura, Y., Yajima, Y., Kawashima, S., Tanaka: "Dehydrotrametenolic Acid Induces Preadipocyte Differentiation and Sensitizes Animal Models of Noninsulin-Dependent Diabetes Mellitus to Insulin"Biol. Pharm. Bull. 25. 81-86 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Aoki, K., Watanabe, K., Sato M., Ikekita, M., Hakamatsuk, T.: "Effects of rhizoxin, a microbial angiogenesis inhibitor, on angiogenic endothelial cell functions"Eur. J. Pharmaco. 17. 131-138 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 矢島由紀子, 佐藤真友美, 川島誠一: "脂肪細胞の分化とその機能におけるカルパインの役割"内分泌・糖尿病科. (印刷中).

    • Related Report
      2002 Annual Research Report
  • [Publications] Yukiko Yajima, Mayumi Sato, M.Sumida, Seiichi Kawashima: "Mechanism of adult primitive mesenchymal ST-13 preadipocyte differentiation"Endocrinology. (印刷中).

    • Related Report
      2002 Annual Research Report
  • [Publications] Shindo T, Manabe I, Fukushima Y, TobeK, AizawaK,, et al.: "Kruppel-like zinc-finger transcription factor KLP5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling"Nat Med. 8(8). 856-863 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takahashi B, Ohta K, Kawachi E, Fukasawa H. et al.: "Novel retinoid X receptor antagonists: specific inhibition of retinoid synergism in RXR-RAR heterodimer actions"J Med Chem. 45(16). 3327-3330 (2002)

    • Related Report
      2002 Annual Research Report

URL: 

Published: 2002-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi