| Project/Area Number |
14571121
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | KYOTO UNIVERSITY (2003)
University of Tsukuba (2002) |
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Principal Investigator |
TAKADA Yasutsugu Kyoto University, faculty of medicine, Associate professor, 医学研究科, 助教授 (10272197)
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| Co-Investigator(Kenkyū-buntansha) |
谷口 英樹 横浜市立大学, 医学部, 教授 (70292555)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2002: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | fulminant hepatic failure / auxiliary liver transplantation / cytokine / liver regeneration / pig liver transplantation / 肝移植 |
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| Research Abstract |
'Toxic liver syndrome' can lead to considerable morbidity and mortality in some clinical cases of auxiliary partial orthotopic liver transplantation (APOLT) against fulminant hepatic failure (FHF). After inducing FHF to male pigs by the administrarion of alpha-amanitin and lipopolysaccharide, all of the pigs died within 5 days with clinically relevant features of FHF. Pigs under the same condition were rescued by APOLT 8 hours after induction of FHF. When the timing of APOLT was 24 hours after toxin injection, none of the pigs could survive more than 5 days.
Additional treatment with a novel potent cytokine suppressor 'ONO-SM-362' to APOLT prolonged the survival time of these pigs more than 2 weeks. Controlling cytokines being released from necrotic native liver is important to obtain good results of APOLT against FHF.
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