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Development for new cancer vaccine using various kinds of epitope peptides

Research Project

Project/Area Number 14571128
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionThe University of Tokyo

Principal Investigator

TSUNODA Takuya  The University of Tokyo, The Institute of Medical Science, Lecturer, 医科学研究所, 講師 (30275359)

Co-Investigator(Kenkyū-buntansha) TAKAYAMA Takuya  The University of Tokyo, The Institute of Medical Science, Research Associate, 医科学研究所, 助手 (10332579)
TAHARA Hideaki  The University of Tokyo, The Institute of Medical Science, Professor, 医科学研究所, 教授 (70322071)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2003: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2002: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsEpitope peptide / HER2 / neu / p53 / CTL / Cancer vaccine / がんワクチン療法
Research Abstract

Recently, cancer vaccine using epitope peptides was performed all over the world. Epitope peptides induced the strong cytotoxic T lymphocytes (CTL) in cancer patients, therefore clinical trials of cancer vaccine were performed. However, the outcome of clinical trial has not so excellent. One of the reasons was due to the only one target against the cancer. To promote the clinical efficacy, it is important to find the more epitope peptides. In this study, we determined the epitope peptides from HER2/neu and p53 which were significant molecules for cancer. We determined epitope peptides restricted to HLA-A*2402 which was the most common in Japanese. These findings may suggest that mixture of the epitope peptides improve the clinical efficacy of cancer vaccine.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] Matsuda K, Tsunoda T., et al.: "Enhancement of Cytotoxic T Lymphocyte Responese in Patients with Gastrointestinal Malignancies following Vaccination with CEA peptide pulsed Dendritic cells"Cancer Immunology Immunotherpy. Jan20(Epub ahead of print). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Saori Nakahara, Tsunoda T., et al.: "Dendritic cells stimulated with a bacterial product, OK-432, efficiently induce cytotoxic T lymphocytes specific to tumor rejection peptide."Cancer Research. 63. 4112-4118 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shono Y, Tanimura H, Iwahashi M, Tsunoda T, et al.: "Specific T-cell immunity against Ki-ras peptides in patients with pancreatic and colorectal cancers."Br J Cancer. 88. 530-536 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Matsuda K, Tsunoda T., et al.: "Enhancement of Cytotoxic T Lymphocyte Responses in Patients with Gastrointestinal Malignancies following Vaccination with CEA peptide pulsed Dendritic cells"Cancer Immunology Immunotherpy.(Eub ahead of print). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Saori Nakahara, Takuya Tsunoda, et al.: "Dendritic cells stimulated with a bacterial product, OK-432, efficiently induce cytotoxic T lymphocytes specific to tumor rejection peptide."Cancer Research. 63. 4112-4118 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shono Y, Tanimura H, Iwahashi M, Tsunoda T, et al.: "Specific T-cell immunity against Ki-ras peptides in patients with pancreatic and colorectal cancers."Br J Cancer. 88. 530-536 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Matsuda K, Tsunoda T., et al.: "Enhancement of Cytotoxic T Lymphocyte Responses in Patients with Gastrointestinal Malignancies following Vaccination with CEA peptide pulsed Dendritic cells."Cancer Immunology Immunotherpy. Jan 20(Epub ahead of print). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Saori Nakahara, Takuya Tsunoda, et al.: "Dendritic cells stimulated with a bacterial product, OK-432, efficiently induce cytotoxic T lymphocytes specific to tumor rejection peptide."Cancer Research. 63. 4112-4118 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Shono Y, Tanimura H, Iwahashi M, Tsunoda T, et al.: "Specific T-cell immunity against Ki-ras peptides in patients with pancreatic and colorectal cancers."Br J Cancer. 88. 530-536 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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