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Mechanism of cancer metastasis via chemokine and its clinical application

Research Project

Project/Area Number 14571140
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionKyushu University

Principal Investigator

YOSHITAKE Shinichirou  Kyushu Univ.Hospital, Research Associate, 大学病院, 助手 (80315142)

Co-Investigator(Kenkyū-buntansha) MORI Masaki  Medical Institute of Bioregulatlon Kyushu Univ., Professor, 生体防御医学研究所, 教授 (70190999)
岸原 文明  九州大学, 生体防御医学研究所, 助手 (70346849)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2002: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsFractalkine / CX3CR1 / colorectal cancer / CD3^+T lymphocyte / NK cell / RT-PCR / chemokine / CCR7 / gastric carcinoma / CXCL12 / CXCR4 / metastasis / Cell-cycle
Research Abstract

Local and systemic immune responses are impaired in patients with colorectal cancer (CRC) and it is known that the number of tumor infiltrating lymphocytes (TILs) is considerably a few. On the otherhand, some CRC cases that much TIL were observed, are better prognosis than those of few cases. However, it is ordinary that antigenisity make lymphocyte infiltration, it is possible that Fractalkine, one of chemoattractants, without antigenisity also recruit lymphocyte for tumor lesion. We made hypothesis that Fractalkine would recruit lymphocyte in the tumor and play on important role of antitumorimmunity. We analyzed therefore the expression level of Fractaikine in CRC cell lines as well as in clinical samples. The expression level of Fractaikine was correlated with the density of TIL. The CRC cases with strong Fractalkine expression showed better prognosis than those with weak expression. These data suggest that Fractalkineitiducedbythe tumorwouldrecruitlymphocyteto tumor site and these TILs would induce better prognosis. The expression level of Fractaikine was an essential biomarker for predicting prognosis of patient with CRC. Fractalkine was considered to be one the blomarker for the detection of the patients with high risk for recurrence, who might benefit from additional therapeutic strategies such as adjuvant therapy.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Yamaguchi, H., et al.: "Identification of HLA-A24-restricted CTL epitope from cancer-testis antigen, JNY-ESO-1,and induction of a specific anfitumor immune response."Clin Cancer Res. 10. 890-896 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamashita, K., et al.: "Clinical significance of secreted protein acidic and rich in cystein in esophageal carcinoma and its relation to carcinoma progression."Cancer. 97. 2412-2419 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamaguchi, H., et al.: "Stimulation of CD40 inhibits Fas- or chemotherapy-mediated apoptosis and increases cell motility in human gastric carcinoma cells."Int J Oncol. 23. 1697-1702 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tanaka, F et al.: "Intratumoral injection of dendritic cells after treatment of anticancer drugs induces tumor-specific antitumor effect in vivo."Int J Cancer. 101. 265-269 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shibuta, K., et al.: "Regional Expression of CXCL12/CXCR4 in Liver and Heoatocellular Carcinoma and Cell-cycle Variation during in vitro Differentiation"Jpn J Cancer Res. 93. 789-797 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 黒木 保, 井上 裕, 森 正樹: "消化器外科 レビュー:発癌機構(分担執筆)"総合医学社. 268

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamaguchi, H., et al.: "Identification of HLA-A24-restricted CTL epitope from cancer-testis antigen, NY-ESO-1, and induction of a specific antitumor immune response."Clin Cancer Res. 10. 890-896 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamashita, K., et al.: "Clinical significance of secreted protein acidic and rich in cystein in esophageal carcinoma and its relation to carcinoma progression."Cancer. 97. 2412-2419 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamaguchi, H., et al.: "Stimulation of CD4O inhibits Fas-or chemotherapy-mediated apoptosis and increases cell motility in human gastric carcinoma cells."Int J Oncol. 23. 1697-1702 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tanaka, F et al.: "Intratumoral injection of dendritic cells after treatment of anticancer drugs induces tumor-specific antitumor effect in vivo."Int J Cancer. 101. 265-269 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shibuta, K., et al.: "Regional Expression of CXCL12 / CXCR4 in Liver and Hepatocellular Carcinoma and Cell-cycle Variation during in vitro Differentiation"Jpn J Cancer Res. 93. 789-797 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kuroki T, et al.: "SHOKAKIGEKA REVIEW : Carcinogenesis"SHOKAKIGEKA (Japanese). 268(8) (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Masuda TA, Inoue H, et al.: "Cyclin-dependent kinase 1 gene expression is associated with poor prognosis in gastric carcinoma."Clin Cancer Res. 15. 5693-5698 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Matsuyama A, Shiraishi T, et al.: "Fragile site orthologs FHIT/FRA3B and Fhit/Fra 14A2: Evolutionarily conserved but highly recombinogenic"Proc Natl Acad Scl USA. 100. 14988-14993 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yamashita K, Mimori K, et al.: "A tumor-suppressive role for trypsin in human cancer progression."Cancer Res. 63. 6575-6578 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yamashita K, Sunil, et al.: "MAL gene expression in esophageal cancer suppresses motility, invasion and tumorigenicity and enhances apoptosis throughthe Fas pathway"Oncogene. 22. 3463-3471 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Mimori K, Inoue H, et al.: "INI-1, a partner gene of ALL-1, is highly conserved in human acute leukemia"Oncology Rep. 10. 551-553 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Inoue H, Matsuyama A, et al.: "Prognostic score of gastric cancer determined by cDNA microarray"Clin Cancer Res. 8. 3475-3479 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] 黒木 保, 井上 裕, 森 正樹: "消化器外科 レビュー:発癌機構(分担執筆)"総合医学社. 268 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Mashino K, Mori M. et al.: "Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma"Cancer Res. 62. 2937-2941 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shibuta K, Mori M. et al.: "Regional Expression of CXCL12/CXCR4 in Liver and Hepatocellular Carcinoma and Cell-cycle Variation during in vitro Differentiation"Jpn J Cancer Res. 93. 789-797 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Utsunomiya T., Mori M.et al.: "G protein gamma 7 expression as a new clinicopathological marker in patients with intrahepatic cholangiocarcinoma"Arch Surg. 137. 181-185 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Masuda T., Mori M.et al.: "Clinical and Biological Significance of S-Phase Kinase-associated Protein 2 (Skp2) Gene Expression in Gastric Carcinoma : Modulation of Malignant Phenotype by Skp2 Overexpression, Possibly via p27 Proteolysis"Cancer Res. 62. 3819-3825 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yamashita K., Mori M.et al.: "Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma"Cancer Cell. 2. 485-495 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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