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Investigation on the mechanism of chronic rejection in organ transplantation and the development of a new modality evaluating the chronic rejection.

Research Project

Project/Area Number 14571154
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionSaitama Medical University

Principal Investigator

KOYAMA Isamu  Saitama Medical School, Faculty of Medicine, Professor, 医学部, 教授 (60178390)

Co-Investigator(Kenkyū-buntansha) MIYAZAWA Mitsuo  Saitama Medical School, Faculty of Medicine, 医学部, 助教授 (20200165)
OGAWA Nobuji  Saitama Medical School, Faculty of Medicine, Assistant Professor, 医学部, 講師 (60286044)
TAKAHASHI Kouichi  Saitama Medical School, Faculty of Medicine, Fellow, 医学部, 助手 (40306311)
Project Period (FY) 2002 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2004: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2002: ¥800,000 (Direct Cost: ¥800,000)
KeywordsChronic rejection / Immunological status / TGF-β / MMP-2 / Immunosuppressive acidic protein / Nitric Oxide
Research Abstract

The pathological findings of an end stage chronic rejection are the fibrosis of the interstitial space, resulting in the atrophy of the organs. Various kinds of growth factor might be associated with the process of the fibrosis. Among of them, we focused TGF-β and MMP-2 which have thought to be most related to the tissue fibrosis, and we examined in the first whether or not these two growth factor or cytokine would help to predict the development of chronic rejection. Moreover, it was studied whether immunosuppressive acid proteins (IAP) and NO (nitric oxide) help to evaluate the immunological status in the chronic stage after renal transplantation. The TGF-β value was elevated in the patients with poor renal function in the late stage after renal transplantation. However, the doubt remained about utility of the TGF-β as the marker of the diagnosis at the early stage of a chronic rejection. As for MMP-2, a significant difference was not seen between the normal kidney function group and the poor kidney function group. In addition, it was suggested that serum Cr level of 3mg/dl and serum NO value of 150μmol/L might be able to predict the renal graft lost within one year, which turned out the NO measurement also help to diagnose the early stage of the chronic period rejection. The monitoring of the immunological status after transplantation is very important for obtaining an appropriate immunosuppression, which may help to prevent from chronic rejection. Differential diagnosis between chronic rejection and viral infection was difficult by only the measurement of IAP, although serum IAP value was useful as the immunological monitoring. We developed a new method of immunological monitoring after transplantation in which the patients' lymphocytes were analyzed with FACS for DNA pattern under the stimulation with a super antigen. This new method might be helpful to predict the development of chronic rejection in future.

Report

(4 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (16 results)

All 2004 2002 Other

All Journal Article (13 results) Publications (3 results)

  • [Journal Article] 免疫抑制剤におけるCFSE法を用いた新たな免疫モニタリングについて2004

    • Author(s)
      高橋公一, 小川展二, 小山勇他
    • Journal Title

      移植 39(臨)

      Pages: 346-346

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 難治性拒絶反応に対する治療効果-他剤からの切り替え症例-2004

    • Author(s)
      小川展二, 小山勇
    • Journal Title

      今日の移植 17(4)

      Pages: 543-550

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Tissue engineered patch for the reconstruction of the portal and hepatic veins during adult-to-adult living-donor partial liver transplantation2004

    • Author(s)
      M.Miyazawa et al.
    • Journal Title

      American Journal of Transplantation 14 (Suppl 18)

      Pages: 171-171

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Augumentation of T-cell apoptosis by immunosuppressive agents2004

    • Author(s)
      K.Takahashi et al.
    • Journal Title

      Clinical Transplant 18(Suppl 12)

      Pages: 72-75

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Augumentation of T-cell apoptosis by immunosuppressive agents2004

    • Author(s)
      Takahashi K, et al.
    • Journal Title

      Clinical Transplant 18(Suppl 12)

      Pages: 72-75

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A new monitoring method for evaluating immune system using CFSE under immunosuppressive drungs.2004

    • Author(s)
      Takahashi K, et al.
    • Journal Title

      Ishoku (Japanese) 39

      Pages: 346-346

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Treatment against intractable chronic rejection.2004

    • Author(s)
      Ogawa N, et al.
    • Journal Title

      Transplantation Today (Konnnichi No Ishoku) 17(4)

      Pages: 543-550

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Tissue engineered patch for the reconstruction of the portal and hepatic veins during adult-to-adult living-donor partial liver transplantation.2004

    • Author(s)
      Miyazawa M, et al.
    • Journal Title

      Am J Transplantation 4(Suppl 18)

      Pages: 171-171

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 免疫抑制剤におけるCFSE法を用いた新たな免疫モニタリングについて2004

    • Author(s)
      高橋公一, 小川展二, 小山勇 他
    • Journal Title

      移植 39(臨)

      Pages: 346-346

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 難治性拒絶反応に対する治療効果-他剤からの切り替え症例2004

    • Author(s)
      小川展二, 小山 勇
    • Journal Title

      今日の移植 17(4)

      Pages: 543-550

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 人工心肺下コアークーリング法による心停止ドナーからの腎摘出2004

    • Author(s)
      小山 勇, 小川展二, 宮澤光男他
    • Journal Title

      今日の移植 17(5)

      Pages: 646-650

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Total Body Cooling Using Cardiopulmonary Bypass for Procurement From Non-Heart-Beating Donors2002

    • Author(s)
      I.Koyama et al.
    • Journal Title

      Transplant Proceedings 34(7)

      Pages: 2602-2603

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Total body cooking using cardiopulmonary bypass for procurement from non-heart beating donors.2002

    • Author(s)
      Koyama, I, et al.
    • Journal Title

      Transplant Proceedings 34(7)

      Pages: 2602-2603

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] 小川展二, 浅野 博, 小山 勇, 他: "腎移植患者に対するセルセプトの副作用と移植経過についての検討"移植. 38. 288 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 小川展二, 浅野 博, 小山 勇 他: "慢性進行性拒絶反応症例に対するセルセプトの使用経験"日本臨床腎移植学会誌(学会抄録). 臨時. 101 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 小川展二, 官澤光男, 小山勇 他: "腎移植後慢性拒絶反応に対し維持免疫療法としてMMFに変更した11例の検討"日本移植学会雑誌. 37(臨). 323-323 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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