| Project/Area Number |
14571232
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tokai University |
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Principal Investigator |
MAKUUCHI Hiroyasu Tokai University, School of Medicine, Professor, 医学部, 教授 (80095645)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMADA Hideo Tokai University, School of Medicine, Assistant Professor, 医学部, 講師 (40206173)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2003: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2002: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | Barrett's cancer / Barrett's esophagus / Barrett's mucosa / Endoscopic diagnosis / columnar epithelium / intestinal metaplasia / Endoscopic mucosal resection / EMR / Burrett食道癌 / Burrett食道 / Burrett粘膜 / Barrett粘膜 / short segment Barrett's esophagus |
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| Research Abstract |
Barrett's esophagus (long Barrett's esophagus) is defined as totally circumferential spread of columnar epithelium for longer than 3cm spreading from esophago-gastric junction, and short segment Barrett's esophagus (SSBE) is defined as its spread shorter than 3cm or not totally circumferential, according to Japan Society of Esophageal Diseases. Barrett's mucosa is mostly accompanied by incomplete intestinal metaplasia, which is postulated to develop Barrett's esophageal cancer.
Increasing interest on Barrett's esophagus and Barrett's cancer in Japan and progress on endoscopic diagnosis have improved the detection of Barrett's esophageal cancer, especially in its early stage. Endoscopic mucosal resection has been performed recently in those cases. The question arises whether to adopt the clinical classification of esophageal cancer or of gastric cancer in Barrett's cancer cases. Though its pathology is adenocarcinoma, the location is in esophagus, and the authors advocate to adopt the esophageal classification. Actual application of clinical classification of esophageal cancer to Barrett's cancer resulted in clear correlation between clinical type and depth of invasion.
Prognosis of Barrett's cancer is rather good in its superficial state, but becomes poor in advanced stage reflected by 70% of advanced cancer patients already dead due to the cancer. It might be due to the development of undifferentiated cancer cells in the course of cancer progress.
As treatments, endoscopic mucosal resection and other endoscopic procedures are indicated to Tla Barrett's cancer. To the advanced cancer beyond Tlb, surgical operations are indicated and their maneuvers depend on the length of Barrett's esophagus, location and stage of cancer.
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