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The establishment of the functional bowel disorders treatment based on the pathophysiological study

Research Project

Project/Area Number 14571238
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionNihon University

Principal Investigator

AOKI Nobuhiko  Nihon University, School of Medicine, 医学部, 講師 (70318393)

Co-Investigator(Kenkyū-buntansha) TOMITA Ryouichi  Nippon Dental University, School of Dentistry, 教授 (50164025)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2003: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2002: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsBowel functional disorders / Pathophysiology / Gastrointestinal Motility / Constipation / Motility Patterns / Treastment / 組織学的検査
Research Abstract

We measured the pressure activity of sigmoid colon and rectum to the normal control 4 cases, the chronic constipation 3 cases. We used a flexible probe containing three straingauge pressure transducers (P31-30 : KONIGSBERG INSTRUMENTS. INC.) that were located 2,12 and 27cm from the anus. The probe was attached to a portable pocket monitor (GMMS-300 : STAR MEDICAL.. INC.) and pressure activity recorded.
The number of the contraction waves for every one hour was analyzed, and moreover we classified the contraction waves into I-IV type waves of Code.
In the normal cases there were many numbers of the waves compared with the chronic constipation patients and the number of the waves in 2-4 hours after meal increased. Moreover, it admitted the increase number of the wave of the I, II, IV.type.
Chronic constipation patients showed less pressure activity than the normal cases. It didn't admit the increase of the number of the waves of 2-4 hours after meal and it admitted the increase of neither t … More he I-IV type waves.
It thought that it became more accelerate which is accompanied by the active contraction wave by the meal in the normal cases. In the chronic constipation, the fact that a gastrocolic-reflex by the meal is done in the fault was suggested.
But the accumulation of further case seems to be necessary, because there are currently few numbers of the cases.
The way of measuring pressure in the sigmoid colon and rectum for about 7 hours from the anus using the portable pocket monitor, could record the load of the patient in the good quality of life, and the more natural condition.
It thought that this way was important as the way of examining the pathophysiological of the functional bowel disorder.
In the future, if adding 24hr measurements, the detailed analysis of the propagating pressure waves, the reviewing which combines the other colorectal examination, the reviewing of a rectum biopsy, it thought that it is possible development of the more accurate treatment of the functional bowel disorder. Less

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (42 results)

All 2006 2005 2004 2003 2002 Other

All Journal Article (30 results) Publications (12 results)

  • [Journal Article] 慢性便秘症例における腸内圧波形の型分類による検討2006

    • Author(s)
      青木信彦, 富田涼一, 萩原紀嗣
    • Journal Title

      日本外科系連合学会誌 31

      Pages: 628-628

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 陰部神経機能検査法について2006

    • Author(s)
      富田涼一
    • Journal Title

      Medical Postgraduates 44

      Pages: 309-312

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 結腸縦走筋の壁内神経調節からみた輸送遅延型慢性便秘症の病態生理学的検討2006

    • Author(s)
      富田涼一
    • Journal Title

      日本臨床生理学会雑誌 36

      Pages: 25-29

    • NAID

      10017572915

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 【Hirschsprung病類縁疾患を学ぶ】成人のHirschsprung病類縁疾患2006

    • Author(s)
      富田涼一, 越永従道
    • Journal Title

      小児外科 38

      Pages: 778-784

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] The classifed Motility Patterns of the Sigmoid colon and Rectum in chronic constipation2006

    • Author(s)
      N Aoki, R Tomita, N Hagiwara
    • Journal Title

      J Japanese College of Surgeons Vol31

      Pages: 28-28

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Physiological tests on Pudendal Nerve.2006

    • Author(s)
      R Tomita
    • Journal Title

      Medical Postgraduates Vol44

      Pages: 309-312

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Enteric Nervous System in the Longitudinal Colonic Muscle of Patients with Slow Transit Constipation.2006

    • Author(s)
      R Tomita
    • Journal Title

      Jpn J clic Physiol Vol36

      Pages: 25-29

    • NAID

      10017572915

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Allired Disorders o Hirschsprung's disease in Adult.2006

    • Author(s)
      R Tomita, T Koshinaga
    • Journal Title

      Jpn. J. Pediatr. Surg. Vol38

      Pages: 778-784

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 小児慢性便秘症の直腸・肛門生理機能検査について2005

    • Author(s)
      富田涼一
    • Journal Title

      Medical Postgraduates 43

      Pages: 132-135

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 大腸憩室症の病態生理 In vitroの研究2005

    • Author(s)
      富田涼一
    • Journal Title

      消化器科 41

      Pages: 209-214

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 直腸運動型分類からみた輸送遅延型慢性便秘症の病態生理2005

    • Author(s)
      萩原紀嗣, 富田涼一, 福澤正洋
    • Journal Title

      日本消火器外科学会雑誌 38

      Pages: 1288-1295

    • NAID

      110001553587

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Physiological Tests of the Recctum and Anal Canal for Patients with chronic Constipation in Children.2005

    • Author(s)
      R Tomita
    • Journal Title

      Medical Postgraduates Vol43

      Pages: 132-135

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Pathophysiological studies in the colon of patients with diverticular diseas-An in vitro study2005

    • Author(s)
      R Tomita
    • Journal Title

      Gastroenterology Vol41

      Pages: 209-214

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] The Motility Patterns of the Recutum in Slow Transit Type Chronic Constipation2005

    • Author(s)
      N Hagiwara, R Tomita, M Fukuzawa
    • Journal Title

      Jpn J Gastroenterol Surg Vol38

      Pages: 1288-1295

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Hirschsprung病における内肛門括約筋の神経支配について2004

    • Author(s)
      富田涼一
    • Journal Title

      Medical Postgraduates 42

      Pages: 261-265

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 消火器の臨床生理 慢性便秘症の壁内神経系調節からみた病態生理2004

    • Author(s)
      富田涼一, 池田太郎, 五十嵐誠悟, 竹川本夫, 河村博
    • Journal Title

      日本臨床生理学会雑誌 34

      Pages: 57-57

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 移送遅延型慢性便秘症の神経調節について2004

    • Author(s)
      富田涼一, 丹正勝久, 藤崎滋, 柴田昌彦, 池田太郎, 朴英智, 竹川本夫
    • Journal Title

      日本臨床外科学会雑誌 65

      Pages: 596-596

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Innervation of the internal anal sphincter in patients with Hirschsprung's disease.2004

    • Author(s)
      R Tomita
    • Journal Title

      Medical Postgraduates Vol42

      Pages: 261-265

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Pathophysiological studies of the enteric nerveous system in patients with chronic constipation2004

    • Author(s)
      R Tomita, T Ikeda, S Igarashi, M Takekawa, H.Kawamura
    • Journal Title

      Jpn J clic Physiol Vol34

      Pages: 57-57

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] The nervous regulation in patients with slow transit constipation.2004

    • Author(s)
      R Tomita, K Tanjo, S Fujisaki, M Shibata, T Ikeda, E Paku, M Takekawa
    • Journal Title

      Jpn J clic Surgl Vol65

      Pages: 596-596

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 消化管運動におけるInterleukin-1β(IL-1β)の役割2003

    • Author(s)
      富田涼一
    • Journal Title

      Medical Postgraduates 41

      Pages: 427-432

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Role of Interleukin-1β(IL-1β) in the Gut.2003

    • Author(s)
      R Tomita
    • Journal Title

      Medical Postgraduates Vol41

      Pages: 427-432

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 直腸肛門疾患の検査方法 特に生理機能的検査法について2002

    • Author(s)
      富田涼一
    • Journal Title

      Medical Postgraduates 40

      Pages: 376-382

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Role of nitric oxide in the colon of patients with slow-transit constipation2002

    • Author(s)
      R Tomita, S Fujisaki, T Ikeda, M Fukuzawa, M
    • Journal Title

      Disease of the Colon and Rectum 45

      Pages: 593-600

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Role of nitric oxide in the internal anal sphincter of Hirschsprung's Disease2002

    • Author(s)
      R Tomita, S Fujisaki, T Ikeda, M Fukuzawa
    • Journal Title

      World Journal of Surgery 26

      Pages: 1493-1498

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Regulation of the enteric nervous system in the colon of patients with slow-transit constipation2002

    • Author(s)
      R Tomita, K Tanjoh, S Fujisaki, T Ikeda, M Fukuzawa
    • Journal Title

      Hepatogastroenterology 49

      Pages: 1540-1544

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Physiological tests of the rectum and anal canal.2002

    • Author(s)
      R Tomita
    • Journal Title

      Medical Postgraduates Vol40

      Pages: 376-382

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Role of nitric oxide in the colon of patients with slow-transit constipation.2002

    • Author(s)
      R Tomita, S Fujisaki, T Ikeda, M Fukuzawa, M
    • Journal Title

      Disease of the Colon and Rectum Vol45

      Pages: 593-600

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Role of nitric oxide in the internal anal sphincter of Hirschsprung's Disease.2002

    • Author(s)
      R Tomita, S Fujisaki, K Tanjoh, M Fukuzawa
    • Journal Title

      World Journal of Surgery Vol26

      Pages: 1493-1498

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Regulation of the enteric nervous system in the colon of patients with slow-transit constipation.2002

    • Author(s)
      R Tomita, K Tanjoh, S Fujisaki, T Ikeda, M Fukuzawa
    • Journal Title

      Hepatogastroenterology Vol49

      Pages: 1540-1544

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 富田凉一, 池田太郎, 藤崎 滋, 柴田昌彦, 福澤正洋: "輸送遅延型慢性便秘症例に対する回腸直腸吻合術"手術. 56. 639-643 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] T Tomita, S Fujisaki, T Ikeda, M Fukuzawa: "Role of nitric oxide in the colon of patients with slow-transit constipation"Disease of the Colon and Rectum. 45. 593-600 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] R Tomita, S Fujisaki, K Tanjoh, M Fukuzawa: "Role of nitric oxide in the internal anal sphincter of Hirschsprung's Disease"World Journal of Surgery. 26. 1493-1498 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] R Tomita, K Tanjoh, S Fujisaki, t Ikeda, M Fukuzawa: "Regulation of the enteric nervous system in the colon of patients with slow transit constipation"Hepatogastroenterology. 49. 1540-1544 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] 富田凉一: "直腸肛門疾患の検査方法-特に生理機能的検査法について-"Medical Postgraduates. 40. 376-382 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] 富田凉一, 藤崎 滋, 丹正勝久, 福澤正洋: "潰瘍性大腸炎における胃排出機能について"日本大腸肛門病学会雑誌. 56. 109-113 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 富田涼一, 池田太郎, 藤崎滋, 柴田昌彦, 福澤正洋: "Soilingを伴う高齢者直腸脱のS2-4脊髄神経根刺激伝導時間からみた電気生理学的検討"日本外科系連合学会雑誌. 27. 72-76 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 富田涼一, 池田太郎, 藤崎滋, 柴田昌彦, 丹正勝久, 福澤正洋: "男性におけるrectoceleの検討"日本外科系連合学会雑誌. 27. 224-228 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] R Tomita, S Fujisaki, T Ikeda, M Fukuzawa: "Role of nitric oxide in the colon of patients with slow-transit constipation"Disease of the Colon and Rectum. 45. 593-600 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] R Tomita, S Fujisaki, K Tanjoh, M Fukuzawa: "Role of nitric oxide in the internal anal sphincter of Hirschsprung's disease"World Journal of Surgery. 26. 1493-1498 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] R Tomita, K Tanjoh, S Fujisaki, T Ikeda, M Fukuzawa: "Regulation of the enteric nervous system in the colon of patients with slow transit constipation"Hepatogastroenterology. 49. 1540-1544 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 富田涼一: "直腸肛門疾患の検査方法-特に生理機能的検査法について-"Medical Postgraduates. 40. 376-382 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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