Photodynamic therapy for peripheral lung cancer
| Project/Area Number |
14571281
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
TSUTSUI Hidemitsu Tokyo Medical University, Medicine, Assistant Professor, 医学部, 助手 (50328233)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Kimito Tokyo Medical University, Medicine, Assistant Professor, 医学部, 助手 (10349475)
HARADA Masahiko Tokyo Medical University, Medicine, Assistant Professor, 医学部, 助手 (60328242)
USUDA Jitsuo Tokyo Medical University, Medicine, Assistant Professor, 医学部, 助手 (60338803)
KATO Harubumi Tokyo Medical University, Medicine, Professor, 医学部, 教授 (20074768)
土田 敬明 東京医科大学, 医学部, 講師 (80256239)
奥仲 哲弥 東京医科大学, 医学部, 講師 (80233469)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2003: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2002: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | photodynamic therapy / PDT / peripheral lung cancer / interstitial illumination / Photofrin / ATX-S10Na(II) / ATX-S10(Na) |
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| Research Abstract |
[Study Objective] This study was conducted to investigate the potentiality of photodynamic therapy (PDT) as the minimally invasive treatment for peripheral lung cancer. We investigated the effect of interstitial PDT on normal pig lung parenchyma. [Materials & Methods] Photofrin or ATX-S10Na(II) was administered intravenously prior to PDT. Under general anesthesia, a diffuser fiber was inserted into the lung parenchyma via a percutaneous introducer needle and illumination was performed using a diode laser at a wavelength of 630nm or 670nm Pigs were killed 3 days after PDT to assess the effects. [Results] All pigs vered after PDT without serious complications. PDT produced a sharply defined zone of hemorrhagic necrosis on normal lung parenchyma. The zone of necrosis, which was encapsulated by surrounding granulation tissue, was homogeneous irrespective of the distance from the fiber. There was no destruction of the visceral pleura structure surrounding the site of puncture. Photofrin med
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iated PDT produced necrosis of 10mm in diameter under the illumination condition of 100-400J/cm at 100mW/cm. Under the same total light dose, the lower power of 10mW/cm produced consistently larger necrosis than that of 100mW/cm (p<0.01) and the same result was obtained starting at 10mW/cm then increasing the power level to 100mW/cm. ATX-S10Na(II) mediated PDT produced necrosis up to 11.5mm in diameter, and the photodynamic effect produced consistently larger necrosis than that of Photofrin mediated PDT under the same illumination condition (p<0.01). Using a novel, fiber movement device (rotating and reciprocating), the size of necrosis increased up to 15mm in diameter. [Conclusion] Interstitial PDT may preserve pulmonary function by producing localized homogeneous necrosis surrounded by granulation tissue. PDT effect could be enhanced by optimization of illumination and/or using second generation photosensitizer. The results suggest PDT may be a promising new minimally invasive technique for treating localized peripheral lung cancer. Less
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Report
(3 results)
Research Products
(3 results)
