Immunotherapeutic mechanism on dendritic cell therapy for malignant glioma
| Project/Area Number |
14571303
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Cerebral neurosurgery
|
|---|
| Research Institution | KANAZAWA UNIVERSITY |
|---|
Principal Investigator |
THCHIBANA Osamu Kanazawa University, Kanazawa University Hospital, Lecturer, 医学部附属病院, 講師 (40211362)
|
|---|
| Project Period (FY) |
2002 – 2003
|
| Project Status |
Completed (Fiscal Year 2003)
|
| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2003: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2002: ¥2,200,000 (Direct Cost: ¥2,200,000)
|
|---|
| Keywords | malignant glioma / dendritic cell / immunotherapy / granzyme-B / death receptor / death effecter |
|---|
| Research Abstract |
Intradermal cervical vaccinations of tumor-lysate or apoptotic GB cells-pulsed dendritic cells were administered to ten patients with malignant astrocytic tumors(9 : glioblastomas, 1 : anaplastic astrocytoma).Dendritic cell vaccination elicited systemic cytotoxity in three of ten patients.A large number of intratumoral cytotoxic and helper T cell infiltration was detected in three of five patients who underwent reoperation or autopsy after vaccination. A large number of infiltrating T cells were immunoreactive for granzyme-B, and negative for Fas-ligand and TRAIL..Tumor volume was remarkably decreased in two cases after immunotherapy. Furthermore, more cytotxic T cells were detected in cervical lymph nodes than in femoral lymph nodes of four autopsy cases. The median survival times for this study and control group were 499 and 410 days, respectively. These results suggested that immunoresponse for brain tumors depends on cervical Lymph nodes and infiltrating T cells attacked target cells using with granzyme-B.
|
Report
(3 results)
Research Products
(6 results)
