Experimental studies on the clinical appliance of hippocampal transection to I intractable mesiotemporal lobe epilepsy
| Project/Area Number |
14571321
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kagoshima University |
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Principal Investigator |
IMAMURA Shinichi Kagoshima University, University Hospital, Facultyof Medicine and Dentistry, Research Associate, 歯学部附属病院, 助手 (60315439)
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| Co-Investigator(Kenkyū-buntansha) |
TAKESHIMA Hideo Kagoshirna University, University Hospital, Facultyof Medicine and Dentistry, Assistant Professor, 医学部・歯学部附属病院, 講師 (70244134)
KURATSU Jun-ichi Kagoshima University, Graduate School of Medical and Dental Sciences, Professor, 大学院・医歯学総合研究科, 教授 (20145296)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2002: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | temporal lobe epilepsy / limbic seizures / kainic acid / spontaneous seizures / intractable epilepsy / epilepsy surgery / hippocampal transection / rat / rat / intractable epilepsy |
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| Research Abstract |
Experiments were carried out on six male Wistar rats developed with spontaneous amygdalar seizures including spontaneous limbic seizure(SLS)and spontaneous secondarily generalized seizure(SSGS).Evaluation of electrobehavioral changes were evaluated before and after the transection between dorsal and ventral hippocampus using wire.While a total of 18 seizures were captured (SLS : 12, SSGS : 6)before transection, only 8 seizures(SLS : 8, SSGS : 0)were found after transection.It appears that hippocampal ti~ansection eliminated SSGS and decreased SLS.Hippocampal transection attenuated ictal activities of spontaneous amygdalar seizures in rats most likely due to reducing intrahippocampal ictal interaction.
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Report
(3 results)
Research Products
(8 results)
