| Project/Area Number |
14571348
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Fukuoka University |
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Principal Investigator |
IWASA Mitsutoshi (2003) Fukuoka University, School of Medicine, Assistant, 医学部, 助手 (40341416)
継 仁 (2002) 福岡大学, 医学部, 助手 (80279273)
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| Co-Investigator(Kenkyū-buntansha) |
TSUGU Hitoshi Fukuoka University, School of Medicine, Lecturer, 医学部, 講師 (80279273)
LEE Sannamu Fukuoka University, Faculty of Science, Assistant, 理学部, 助手 (40248472)
FUKUSHIMA Takeo Fukuoka University, School of Medicine, Professor, 医学部, 教授 (10078735)
岩朝 光利 福岡大学, 医学部, 助手 (40341416)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2003: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | SGP / U87-MG / cytotoxic / apoptosis / necrosis / pore-forming / lipid bilayer / 膜作用性球状人工蛋白質(SGP) / U87MG |
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| Research Abstract |
Artificially designed pore-forming small globular protein (SGP) has membrane-disrupting properties and anti-tumor activity We applied this protein to malignant brain tumor. The study shows that not only diminishing tumor volume but also tumor curing without recurrence. We compared SGP with CDDP (Cisplatin) which is therapeutically used for malignant brain tumor. But CDDP couldn't extinguish tumor lesion.
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