| Project/Area Number |
14571369
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE |
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Principal Investigator |
TAJIMA Fumihiro Hamamatsu University, School of Medicine, Department of Rehabilitation Medicine, Associate Professor, 医学部附属病院, 助教授 (00227076)
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| Co-Investigator(Kenkyū-buntansha) |
NAGANO Akira Hamamatsu University, School of Medicine, Department of Orthopedic Surgery, Professor and Chairman, 医学部, 教授 (50272547)
MIZUSHIMA Takashi Hamamatsu University, School of Medicine, Department of Rehabilitation Medicine, Senior Instructor, 医学部附属病院, 助手 (80279348)
田島 文博 浜松医科大学, 医学部附属病院, 助教授 (00227076)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2003: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2002: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | Sympathetic nervous system / Cerebrovascular disorders / Autonomic dysfunction / Muscle strength training / Isometric exercise / Hemiplegia / Heart rate / Pressor responses / 片麻痺 / 等尺性運動 |
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| Research Abstract |
Although isometric exercise is useful for improvement of muscle strength in unaffected limbs of patients with cerebrovascular accidents (CVA), the pressor responses induced by cardiovascular changes during static exercise in CVA patients are not well defined. We compared the cardiovascular responses to static exercise of elbow flexor muscle between 8 patients with 3-month history of CVA who had documented damage of subcortical structures and 8 control men. Changes in heart rate (HR), arterial blood pressure (BP) and muscle sympathetic nerve activity (MSNA), recorded from the peroneal nerve on the affected side, were determined before, during and after a 2-min sustained contraction of elbow flexor muscles at 35% maximal voluntary contraction. During the control period, the mean burst count of MSNA in CVA patients (64.5±5.0 beats/100HR) was higher than in control subjects (43.5±7.1 beats/100HR) (P<K 0.05). Total MSNA (the mean burst amplitude per minute times burst rate) increased significantly in CVA and control during static exercise by 18.7±6.3% and 95.8±25.2%, respectively. The percent changes in total MSNA, HR and MBP in CVA patients were attenuated during static exercise, compared with the control subjects. Our results indicated the presence of intact pressor responses during static exercise in CVA patients although the magnitudes of such responses were attenuated relative to the control. Therefore, damage of subcortical structures might be involved in lowering the pressor response during exercise. Our results indicate that static exercise does not put patients with CVA at risk of marked increases in HR and BP.
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