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Regulation of Bone Formation by Mechanical Stress

Research Project

Project/Area Number 14571374
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionShiga University of Medical Science

Principal Investigator

IMAI Shinji  Shiga University of Medical Science, Faculty of Medicine, Associate Professor, 医学部, 助教授 (90283556)

Co-Investigator(Kenkyū-buntansha) MATSUSUE Yoshitaka  Shiga University of Medical Science, Faculty of Medicine, Professor, 医学部, 教授 (30209548)
Project Period (FY) 2002 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2004: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2003: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2002: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsosteogenesis / osteoblast / mechanical stress / HB-GAM / knockout mice / 力学的環境 / 不動化試験 / 骨細胞 / 細胞動員 / Syndecan-3 / Knockout mice / inbred
Research Abstract

The purpose of the current project is to provide a scientific basis for our working hypothesis that HB-GAM acts as the putative mediator for the mechanical adaptation of bone formation. Using HB-GAM knockout mice, we have gained below-listed results.
1.HB-GAM knockout mice ware born without apparent patterning defects. However, late-emerging growth retardation of the long bone becomes evident.
2.Detailed bone morphometry revealed that bone formation rate is significantly reduced in the HB-GAM null mutant mice.
3.Although bone resorption rate is reduced in the HB-GAM null mutant mice, it is not as much as bone formation rate. Thus, osteopenia of HB-GAM null mutant mice results mostly from low bone formation rate.
4.Immobilization by the resection of sciatic nerve reduces mechanical loads to the long bones and lowers bone formatin rate. The reduction rate of bone formation by immobilization is as much as that occurred in the HB-GAM null mutant mice.
5.Increase of mechanical stress by physical exercise enhances bone formation activities. However, exercise-associated increase of bone formation was absent from the HB-GAM null mutant mice.
6.These results were compatible with our hypothesis that HB-GAM acts as the putative mediator for the mechanical adaptation of bone formation.

Report

(4 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (20 results)

All 2005 2004 Other

All Journal Article (9 results) Book (2 results) Publications (9 results)

  • [Journal Article] Posttraumatic Recurrent Dislocation of Extensor Pollicis Brevis Tendon over the Metacarpophalangeal Joint2005

    • Author(s)
      Imai S, Kikuchi K, Matsusue Y
    • Journal Title

      J Hand Surg (Am) 30

      Pages: 147-150

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Nociceptive pathway and pathology of low back pain2005

    • Author(s)
      Imai S
    • Journal Title

      Current Rheumatology Reviews 1

      Pages: 167-176

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Posttraumatic Recurrent Dislocation of Extensor Pollicis Brevis Tendon over the Metacarpophalangeal Joint.2005

    • Author(s)
      Imai S, Kikuchi K, Matsusue Y.
    • Journal Title

      J Hand Surg. 30A

      Pages: 147-150

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Nociceptive pathway and pathology of low back pain.2005

    • Author(s)
      Imai S.
    • Journal Title

      Current Rheumatology Reviews 1

      Pages: 167-176

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Spontaneous Rupture of the Flexor Digitorum Profundus and Sublimus of the Index finger and the Flexor Pollicis Longus Without Labor-associated Tendon Loading2004

    • Author(s)
      Imai S, Kubo S, Kikuchi K, Ueba H, Matsusue Y.
    • Journal Title

      J Hand Surg (Am) 29

      Pages: 587-590

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Spontaneous Rupture of the Flexor Digitorum Profundus and Sublimus of the Index finger and the Flexor Pollicis Longus Without Labor-associated Tendon Loading.2004

    • Author(s)
      Imai S, Kubo S, Kikuchi K, Ueba H, Matsusue Y.
    • Journal Title

      J Hand Surg. 29A

      Pages: 587-590

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Chondrocyte differentiation and cartilage repair.2004

    • Author(s)
      Kubo M, Imai S.
    • Journal Title

      Recent Research Development in Cell Biology. Transworld Research Network(Ed : S.G.Pandalai)

      Pages: 155-175

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Spontaneous Rupture of the Flexor Digitorum Profundus and Sublimus of the index finger and the Flexor Pollicis Longus Without Labor-associated Tendon Loading2004

    • Author(s)
      Imai S, Kubo S, Kikuchi K, Ueba H, Matsusue Y.
    • Journal Title

      J Hand Surg (Am) 29

      Pages: 587-590

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Nociceptive pathway and pathology of low back pain

    • Author(s)
      Imai S
    • Journal Title

      Current Rheumatology Reviews (in press)

    • Related Report
      2004 Annual Research Report
  • [Book] Recent Research Development in Cell Biology.2004

    • Author(s)
      Kubo M, Imai S.
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] Recent Research Development in Cell Biology.2004

    • Author(s)
      Kubo M, Imai S.
    • Related Report
      2004 Annual Research Report
  • [Publications] Imai S, Matsusue Y.: "Sarcoidosis in Bone."Acta Orthop Scand. 74. 626-628 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Imai S, Kubo M, Andou K, Kikuchi K, Matsusue Y.: "Transition from Diffuse Cellular Infiltration to Extensive Nodular Granuloma as a Manifestation of Isolated Sarcoidosis in the Hand."J Hand Surg. 28A. 439-442 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Imai S, Kikuchi K, Hori K, Kubo M, Matsusue Y.: "Digital Pacinian Corpuscle Hyperplasia-A Case report and Review of Literature-"Journal of the American Society for Surgery of the Hand.. 3. 175-178 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Imai S, Matsusue Y.: "Neuronal Regulation of Bone Metabolism and Anabolism -Calcitonin gene-related peptide-,Substance P-and Tyrosine Hlydroxylase-containing nerves and the bone"Microsc Res Technique. 58. 61-69 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Imai S, Matsusue Y.: "Reccurrent Solitary Sarcoidosis in Bone -Case Report-"Acta Orthop Scand. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Imai S., Kubo M, Andou K, Kikuchi K, Matsusue Y.: "Transition from Diffuse Cellular Infiltration to Extensive Nodular Granuloma as a Manifestation of Isolated Sarcoidosis in the Hand"J Hand Surg Am. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Omura k, Hukuda S, Katsuura Saruhashi Y, Imanaka T, Imai S.: "Evaluation of posterior long fusion versus conservative treatment for the progressive rheumatoid cervical spine"Spine. 27. 1336-1345 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kubo M, Takase T, Matsusue Y, Rauvala H, Imai S.: "Articular cartilage degeneration and de-differentiation of chondrocytes by the systemic administration of retinyl acetate -ectopic production of osteoblast stimulating factor-1 by chondrocytes in mice"Osteoarthritis Cartilage. 10. 968-976 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Niissalo S, Hukkanen M, Imai S, Tornwall J, Konttinen YT.: "Neuropeptides in experimental and degenerative arthritis"Ann N Y Acad Sci.. 966. 384-399 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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