| Project/Area Number |
14571383
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kagawa University Faculty of Medecine |
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Principal Investigator |
MORI Satoshi Kagawa University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (00190992)
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| Co-Investigator(Kenkyū-buntansha) |
ITANO Toshifumi Kagawa University, Faculty of Medicine, Professor, 医学部, 教授 (60145042)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2003: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2002: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | spinal cord injury / regeneration / radial glia / systemic hypothermia / apoptosis / 放射状グリア / 3CB2抗原 / 軟膜下アストロサイト / アポトーシス細胞死 / 放射状グリア細胞 / 神経再生修復 / GFAP |
|---|
| Research Abstract |
We investigated that prevention of neural cell death and decrease of home mineral density after spinal cord injury (SCI). Systemic hypothermia shows a neuroprotective effect after SCI by attenuating post-traumatic apoptotic cell death.
And, we analyzed mechanism of neural regenerution and repuir after SCI. Our study demonstrated the re-emergence of radial glia after SCI in adult mamnals. Radial glia derived from subpial astrocyte may play an important role in neural repair and regeneration after SCI.
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