Effects of development, maturation, and aging on neural control of upper airway

• Project/Area Number: 14571421
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Chiba University
• Principal Investigator: ISHIKAWA Teruhiko Chiba University, University Hospital, Assistant, 医学部附属病院, 助手 (30272305)
• Co-Investigator(Kenkyū-buntansha): ISONO Shiroh Chiba University, University Hospital, Lecturer, 医学部附属病院, 講師 (80212968)
• Project Period (FY): 2002 – 2003
• Project Status: Completed (Fiscal Year 2003)
• Budget Amount: ¥3,500,000 (Direct Cost: ¥3,500,000); Fiscal Year 2003: ¥200,000 (Direct Cost: ¥200,000); Fiscal Year 2002: ¥3,300,000 (Direct Cost: ¥3,300,000)
• Keywords: larynx / airway protective reflex / development and maturation / pharyngeal patency / sevoflurane / children / mandibular advancement / prone position / 発達 / 成熟 / 成長 / 上気道 / 麻酔

Research Abstract

(1)In previous our study, we reported that collapsibility of the passive pharynx of infants decreases with their development. In the current study, we examined effects of prone position on the collapsibility of passive pharynx including infants and small children. We found the collapsibility was larger in prone position than in supine position. The developmental changes observed in the previous study were kept only in supine position. Published in Am.J.Respir.Grit.Care.Med 2002;166:760-764
(2)Research for airway protective reflexes in children
We examined airway protective reflexes elicited by laryngeal distilled water instillation into the larynx under sevoflurane general anesthesia in children aged from 2 mo to 11 ys). Increasing depth of sevoflurane anesthesia form F_<ET_<sevo>> of 1% to that of 2% resulted in reduction in incidence of active reflexes (swallowing reflex, cough and/or expiration reflex), whereas passive reflexes (apnea, laryngeal closure, laryngospasm) were hardly affected. Maturational effects were not observed in this age category. Submitted to Anesthesiology
(3)Effects of mandibular advancement on laryngeal view during direct laryngoscopy.
Mandibular advancement improved laryngeal view during laryngoscopy. The authors concluded that it has clinical significance since the effect was no less good than that of BURP maneuver. The combination of mandibular advancement and BURP maneuver provided the most excellent laryngeal view. Published in Anesthesiology 2004;100:598-603.

Research Products

• [Publications] Ishikawa, T., Isono, S.et al.: "Prone position increases collapsibility of the passive pharynx in infants and small children"Am.J.Respir.Crit Care Med.. 5. 760-764 (2002)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Tamura, M., Ishikawa, T.et al.: "Mandibular Advancement Improves the Laryngeal View during Direct Laryngoscopy Performed by Inexperenced Physicians"Anesthesiology. 100. 598-603 (2004)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Ishikawa, T., Isono, S., Aiba, J., Tanaka, A., Nishino, T.: "Prone position increases collapsibility of the passive pharynx in infants and small children"Am.J.Respir.Crit.Care.Med.. 166(5). 760-764 (2002)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Tamura, M., Ishikawa, T., Kato, R., Isono, S., Nishino, T.: "Mandibular Advancement Improves the Laryngeal View during Direct Laryngoscopy Performed by Inexperienced Physicians"Anesthesiology. 100(3). 598-603 (2004)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Tamura, M., Ishikawa, T.et al.: "Mandibular Advancement Improves the Laryngeal View during Direct Laryngoscopy Performed by Inexperienced Physicians"Anesthesiology. 100・3. 598-603 (2004)
• [Publications] Ishikawa, T., Isono, S., Aiba, J., Tanaka, A., Nishino, T.: "Prone position increases collapsibility of the passive pharynx in infants and small children"Am. J. Respir. Crit Care Med.. 166. 760-764 (2002)