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Platelet aggregation changes during liver transplantation surgery

Research Project

Project/Area Number 14571431
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

HIRAKATA Hideo  Kyoto University, Graduate School of Medicine, Instructor, 医学研究科, 助手 (70271509)

Co-Investigator(Kenkyū-buntansha) ADACHI Takehiko  Tazuke-Kofukai Medical Research Institute, Thread division, Chief researcher, 第三研究部, 研究主幹 (90252428)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2003: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2002: ¥2,900,000 (Direct Cost: ¥2,900,000)
KeywordsLiver Transplantation / Platelet / Aggregation / Anesthetics
Research Abstract

Blood was collected from patients undergoing liver transplantation surgery at multiple time points and platelet aggregation was analyzed with WBA analyzer (SSR Engineering Co. ltd. Japan). Platelet was stimulated by various concentrations of adenosine-diphosphate, collagen or STA_2, an analog of thromboxane A2. Blood was collected before surgery, right before hepatectomy, during liverless period and after re-perfusion. Platelet aggregation before surgery was the reference value. Platelet aggregation was reduced during surgery in many patients but significant change at a specified period was not observed as patient group at least analyzed with WBA analyzer. This fact does not mean that surgery did not affect platelets at all. It is possible that more sensitive analyzer could detect changes of platelet aggregation. Moreover in fundamental study, we observed significant sensitivity differences between channels of the WBA analyzer, possibly by mechanical problem. Now we are doing efforts to version it up with SSR Engineering Co. ltd. Anesthetics also could affect platelet aggregation during surgery. So the effects of anesthetics on platelet aggregation were determined. These studies reveled that ketamine suppressed platelet aggregation and there are three categories of barbiturates; suppressing, enhancing groups and non -affecting group. When discussing platelet aggregation during surgery, we have to mention anesthetics used at concerned periods.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] Masami Sato, Hideo Hirakata et al.: "Thiamylal and Pentobarbital Have Opposite Effects on Human Platelet Aggregation In Vitro"Anesth Analg. 97. 1353-1359 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Masami Sato, Hideo Hirakata et al.: "Effects of barbiturates on human platelet aggregation differ depending on their chemical structures"Can.J.Physiol.Pharmacol.. 81. 806-814 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takafumi Nakagawa, Hideo Hirakata et al.: "Ketamine suppresses platelet aggregation possibly by suppressed inositol triphosphate formation and subsequent suppression of cytosolic calcium increase"Anesthesiology. 96. 1147-1152 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Masami Sato, Hideo Hirakata, Takefumi Nakagawa, Kyoko Arai, Kazuhiko Fukuda: "Thiamylal and Pentobarbital Have Opposite Effects on Human Platelet Aggregation In Vitro"Anesth Analg. 97. 1353-1359 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Masami Sato, Hideo Hirakata, Mashiro Ikeda, Kazuhiko Fukuda: "Effects of barbiturates on human platelet aggregation differ depending on their chemical structures"Can.J.Physiol.Pharmacol.. 81. 806-814 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takefumi Nakagawa, Hideo Hirakata, Masami Satoh, Kumi Nakamura, Yoshio Hatano, Takashi Nakamura, Kazuhiko Fukuda: "Ketamine suppresses platelet aggregation possibly by suppressed inositol triphosphate formation and subsequent suppression of cytosolic calcium increase"Anesthesiology. 96. 1147-1152 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Masami Sato: "Thiamylal and Pentobarbital Have Opposite Effects on Human Platelet Aggregation in Vitro"Anesth Analg. 97. 1353-1359 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Masami Sato: "Effects of barbiturates on human platelet aggregation differ depending on their chemical structure"Can J Physiol Pharmacol.. 81. 806-814 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takefumi Nakagawa: "Ketamine suppresses platelet aggregation possibly by suppressed inositol triphosphate formation and subsequent suppression of cytosolic calcium increase"Anesthesiology. 96. 1147-1152 (2002)

    • Related Report
      2003 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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