| Project/Area Number |
14571450
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
|
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| Research Institution | Oita University (2003)
大分医科大学 (2002) |
|---|
Principal Investigator |
YAMAMOTO Hitoshi Oita University, 医学部, Teaching fellow (80295188)
|
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| Co-Investigator(Kenkyū-buntansha) |
IWASAKA Hideo Oita University, 医学部, Associate Professor (90175216)
KITANO Takaaki Oita University, 医学部, Associate Professor (20211196)
|
|---|
| Project Period (FY) |
2002 – 2003
|
| Project Status |
Completed (Fiscal Year 2003)
|
| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2002: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | paraquat / HSP47 antisense / collagen / pulmonary fibrosis / HSP47 / 肺線維化 / 線維化 / HSP / アンチセンス |
|---|
| Research Abstract |
Paraquat is a controversial and one of the most commonly used herbicides in the world. Although liver, kidney, heart and CNS are affected, lung damage resulting to pulmonary fibrosis is the usual cause of deaths in the cases with intoxication. The mechanism of paraquat toxicity is not clear but we showed the induction of heat shock protein 47(Hsp47), collagen specific molecular chaperone, related to pulmonary fibrosis. Hsp47 antisense, has beneficial effects on the treatment of fibrosis, and increased survival rate of paraquat treated rat model. The antifibrotic effect of Hsp47 antisense has shown to be due to inhibition of folding, assembly and transport of collagen fibers.
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